Regional Anesthesia for Ophthalmic Surgery
The Sub-Tenon Block
Abstract
Sub-Tenon’s block is a regional anesthetic technique widely used in ophthalmic surgery as a safer alternative to retrobulbar and peribulbar blocks. The technique involves injecting local anesthetic into the sub-Tenon’s space using a blunt cannula after a small incision is made in the conjunctiva and Tenon’s capsule. A thorough understanding of orbital anatomy, conjunctiva, Tenon’s capsule, vascular supply, and innervation of the eye is essential for the success of this block. Various local anesthetics can be used, either alone or in combination, with adjuvants such as hyaluronidase to enhance diffusion and improve block quality. Sub-Tenon’s block provides reliable analgesia with generally adequate akinesia for cataract, vitreoretinal, and other ophthalmic procedures, while carrying a relatively low risk of complications. Other advantages include greater patient comfort and suitability for high-risk groups where needle blocks are contraindicated, such as patients with high myopia or those receiving anticoagulant therapy. Nevertheless, limitations such as incomplete akinesia, particularly of the superior oblique muscle, and the occurrence of chemosis or subconjunctival hemorrhage should be anticipated. With strict aseptic technique, appropriate anesthetic volume, and skilled providers, Sub-Tenon’s block remains an effective, safe, and relevant option in modern ophthalmic anesthesia practice
References
Chua MJ, Lersch F, Chua AWY, Kumar CM, Eke T. Sub-Tenon’s anaesthesia for modern eye surgery – clinicians’ perspective, 30 years after re-introduction. Eye (Lond) [Internet]. 2021 May;35(5):1295–304. Available from: https://doi.org/10.1038/s41433-021-01412-5
Lodhi O, Tabassum TK. Anesthesia for Eye Surgery. In: StatPearls [Internet]. 2023 [cited 2025 Sep 7]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK572131/
Kılıç Y, Gürsoy HH, Bilgeç MD, Bilir A, Güleç MS. Peribulbar vs incisionless sub-Tenon’s blocks: a retrospective cohort study. Eur J Med Res [Internet]. 2024;29(1):1-6. Available from: https://doi.org/10.1186/s40001-024-02251-2
Jones O. The Bony Orbit. Teach Me Anatomy. [Internet].; 2024 [cited 2025 Sep 7]. Available from: https://teachmeanatomy.info/head/organs/eye/bony-orbit/
Jones O. Extraocular Muscles. Teach Me Anatomy. [Internet]. 2022 [cited 2025 Sep 7]. Available from: https://teachmeanatomy.info/head/organs/eye/extraocular-muscles/
Kiel JW. The ocular circulation. In: Levin LA, Nilsson SFE, Ver Hoeve J, Wu SM, Kaufman PL, Alm A, editors. Adler’s Physiology of the Eye. 11th ed. Philadelphia: Elsevier; 2011, 213–42.
Ludwig PE, Aslam S, Chen CC. Anatomy, head and neck: eye muscles. In: StatPearls [Internet]. 2023. [cited 2025 Sep 7]. Available from: https://www.ncbi.nlm.nih.gov/sites/books/NBK470534/
Kaye AD, Urman RD, Vadivelu N. Essentials of Regional Anesthesia. New York: Springer; 2012.
Patel S, Barnacle A, Mailli L, Osborne S, Vahdani K, Ratnam L. The oculocardiac reflex: a rare but significant cardiovascular complication during percutaneous sclerotherapy of a retrobulbar low-flow venolymphatic malformation. Cardiovasc Intervent Radiol. 2023;46(2):271–4. doi:10.1007/s00270-022-03227-9
Guise P. Sub-Tenon anesthesia: a prospective study of 6,000 blocks. Anesthesiology. 2003;98(4):964–8. doi:10.1097/00000542-200304000-00030
Gropper MA, Eriksson LI, Fleisher LA, Cohen NH, Leslie K, Johnson-Akeju O, editors. Miller’s Anesthesia. 10th ed. Philadelphia: Elsevier; 2024.
Kumar CM, Dodds C. Ophthalmic regional blocks. Ann Acad Med Singapore. 2016;35(3):158–67.
Kumar CM, James T. Sub-Tenon’s block. Middlesbrough (UK): James Cook University Hospital; 2020; 1-6.
Shumway CL, Motlagh M, Warrington M. Anatomy, head and neck, eye conjunctiva. In: StatPearls [Internet]. 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK545222/
Eichel R, Goldberg I. Anaesthesia for ophthalmic surgery: sub-Tenon’s block. BMJ Open Ophthalmol [Internet]. 2021;6(1):e000684. doi:10.1136/bmjophth-2020-000684
Guise P. Sub-Tenon’s anesthesia: an update. Local Reg Anesth. 2012;5:35–46. doi:10.2147/LRA.S24553
Ripart J, Nouvellon E, Chaumeron A. Regional anesthesia for eye surgery. Reg Anesth Pain Med. 2005;30(1):72–82. doi:10.1016/j.rapm.2004.09.007
Flood P, Rathmell JP, Urman RD, editors. Stoelting’s Pharmacology & Physiology in Anesthetic Practice. 6th ed. Philadelphia: Wolters Kluwer; 2021
Butterworth JF III, Mackey DC, Wasnick JD, editors. *Morgan & Mikhail’s Clinical Anesthesiology.* 7th ed. New York: McGraw-Hill Education; 2022.
Kumar CM, Eid H, Dodds C. Sub-Tenon’s anaesthesia: complications and their prevention. *Eye (Lond).* 2011;25(6):694–703. doi:10.1038/eye.2011.69
Copyright (c) 2026 Muhammad Ryan Radifan Gustisiya, Sudadi, Djayanti SAri

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
The Contributor and the company/institution agree that all copies of the Final Published
Version or any part thereof distributed or posted by them in print or electronic format as permitted herein will include the notice of copyright as stipulated in the Journal and a full citation to the Journal.












