Association between HLA-B alleles and nevirapine-induced allergies among Indonesian HIV patients

https://doi.org/10.19106/JMedSci004804201604

Angela Satiti Retno Pudjiati(1*), Dyah Ayu Mira Oktarina(2), Hardyanto Soebono(3), Saihas Sauda(4), Dewi Kartikawati Paramita(5), Iwan Dwiprahasto(6), Zubairi Djoerban(7)

(1) Department of Dermatology and Venerology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta
(2) Department of Dermatology and Venerology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta
(3) Department of Dermatology and Venerology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta
(4) Laboratory of Molecular Biology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta
(5) Laboratory of Molecular Biology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta
(6) Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta
(7) Department of Internal Medicine Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
(*) Corresponding Author

Abstract


This study aimed to investigate the association between human leukocyte antigen-B
(HLA-B) alleles and nevirapine allergy in HIV patients in Indonesia. A case control study
was conducted involving 147 HIV patients comprising of 50 patients with and 97
patients without nevirapine allergy as control. The HLA-B allele typing was conducted by
using polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP),
followed by sequencing. Bivariate analysis using Chi-square (X2) test and multivariate
logistic regression with significance level at p<0.05 were applied to analysis the data.
Among 147 subjects, 34 with HLA-B alleles were identified. Bivariable analysis showed
that HLA-B*58 allele was the most significant risk factor for the nevirapine allergy (OR
= 3.67; 95% CI: 1.79 to 7.54), while HLA-B*35 allele was a protective factor (OR =
0.18; 95% CI: 0.08 to 0.42). Multivariate logistic regression analysis showed that young
men and HLA-B*58 allele were the significant risk factors of nevirapine allergy (OR: 4.63;
95% CI: 2.02 to 10.61), while older women with the HLA-B*35 was able to reduce
the risk of nevirapine allergy approximately 81% (OR: 0.19; 95% CI: 0.08 to 0.49). In
conclusion, young male with the HLA-B*58 allele are the high risk factor for nevirapine
allergy in Indonesian HIV patients.

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DOI: https://doi.org/10.19106/JMedSci004804201604

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