Factors influencing plateletpheresis donations in Yogyakarta, Indonesia


Aditya Wicaksana(1*), Teguh Triyono(2), Umi Intansari(3)

(1) Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia,
(2) Department of Clinical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia
(3) Department of Clinical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia
(*) Corresponding Author


Despite its life saving potential, regrettably, blood transfusion has yet to be optimally applied in Indonesia. Funding difficulties and both public and professional lack of knowledge hinders its progress. More lives can be saved by using a safer, more proper, and specialized blood transfusion procedure. Plateletpheresis, one method to obtain platelet products, requires a different donation procedure than that of whole blood-derived platelet. High quality plateletpheresis product donation will positively impact the transfusion efficacy and platelet recovery of the recipient, improving patient’s clinical state. This study analyzes factors from both the donor and donation procedure that influence the quality of plateletpheresis product. The study analyzes data of plateletpheresis donations from blood transfusion service and plateletpheresis transfusions from medical records at Dr. Sardjito General Hospital, Yogyakarta, Indonesia, within the period of August 2012 to January 2013 using cross sectional design. Forty-four plateletpheresis donations were obtained during the study. All donors were male with the following mean values; age 31.9 ± 9.9 years, weight 70.2 ± 10.2 kg, body mass index (BMI) 24.7 ± 3.2 kg/m2, hematocrit 44 ± 3.2 %, and procedure time 84.2 ± 19.2 min. The median value of platelet yield was 3.2x1011 (2.1x1011 – 4x1011). The median value of pre-donation platelet count was 248.5x103/μL (204x103/μL – 391x103/μL) and the mean value of product volume was 275 ± 22.9 mL. The results showed that pre-donation platelet count (r = 0.329; p < 0.05) and product volume (r = 0.661; p < 0.05) positively correlated to the yield of platetetpheresis products. However, the yield of plateletpheresis products was not correlated to the post-transfusion platelet count (r = 0.327; p > 0.05). In conclusion, pre-donation platelet count and product volume of plateletpheresis influence the yield of plateletpheresis. However, the yield is not correlated to the post-donation platelet count. Thus, other clinical factors should be considered


platelet – plateletpheresis – pre-donation – post-donation - platelet count- product

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Platelet transfusion therapy. NIH Consensus Statement. 1986(Oct 8);6:1-6. PMID:3553903. 2. Leukocyte reeduction and ultraviolet B irradiation of platelets to prevent alloimmunization and refractoriness to platelet transfusions. The Trial to Reduce Alloimmunization to Platelets Study Group. N Engl J Med 1997;337:1861-9. DOI: 10.1056/NEJM199712253372601 3. Cable GR, Edwards LR, The use of platelet concentrates versus plateletpheresis-the donor perspective. TRANSFUSION. Volume 41, Issue 6, June 2001;pp. 727-729. DOI: 10.1046/j.1537-2995.2001.41060727.x 4. Patel J, Nishal A, Pandya A, Patel P, Wadhwani S. 2013. Factors influencing yield of platelet aphaeresis using continuous flow cell separator. International Journal of Medical Science and Public Health, 2(3), 323. doi:10.5455/ijmsph.2013.2.323-326. 5. Arun R, Yashovardhan A, Deepthi K, Suresh B, Babu KV, Jothibai DS. 2012. Original Article : Donor demographic and laboratory predictors of single donor platelet yield, pp. 211–215. 6. Buchholz DH, Squires JE, Herman JH, Ng AT, Anderson JK, Hedberg SL. Plateletpheresis in 90-to 110-pound donors using the CS-3000 blood cell separator. Transfusion 1997;37:715-8. 7. Slichter, SJ, Davis, K, Enright, H, Braine, H, Gernsheimer, T, Kao, K-J, Woodson, R. 2005. Factors affecting post transfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patients. Blood, 105(10), 4106–14. doi:10.1182/blood-2003-08-2724. 8. Landzo E, Sofo-Hafizovic A, Cetkovic-Basic V. 2013. Initial values of donor hematocrit and efficiency of plateletpheresis. Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : [časopis Dr..uštva za medicinsku informatiku BiH], 21(2), 116–9. doi:10.5455/aim.2013.21.116-119. 9. Lasky LC, Lin A, Kahn RA, McCullough J. 1981. Donor platelet response and product quality assurance in plateletpheresis. Transfusion:247-60. 10. Das SS, Chaudhary RK., Shukla JS. 2005. Factors influencing yield of plateletpheresis using intermittent flow cell separator. Clinical and laboratory haematology, 27(5), 316–9. doi:10.1111/j.1365-2257.2005.00714.x 11. Murphy S, Vassallo, RR. 2010. ‘Aphaeresis Platelet Collection, Storage, Quality Assessment, and Clinical Use’, in McLeod BC, Szczepiorkowski ZM, Weinstein R, Winters JL (eds.), Aphaeresis: Principles and Practice, 3rd edition. Bethesda, Maryland, pp. 141-165.

DOI: https://doi.org/10.19106/JMedScie/005003201809

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Journal of the Medical Sciences (Berkala Ilmu Kedokteran) by  Universitas Gadjah Mada is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.