Relationship between Hyperuricemia and Erectile Dysfunction on Hypertension Patients in Bethesda Lempuyangwangi Hospital Yogyakarta



Jansje Henny Vera Ticoalu(1), Istiti Kandarina(2*), Dicky Moch. Rizal(3), I Dewa Putu Pramantara Setiabudi(4)

(1) Universitas Gadjah Mada
(2) (Scopus ID = 56845770400), Universitas Gadjah Mada
(3) Fakultas Kedokteran Universitas Gadjah Mada
(4) Rumah Sakit Umum Pusat Dr. Sardjito, Yogyakarta
(*) Corresponding Author

Abstract


Background: Hypertension is now a major non-communicable disease in Indonesia and worldwide. Hypertension patients are susceptible to erectile dysfunction, especially through vasculogenic pathway. In this setting, uric acid level could be a promising biomarker to predict erectile dysfunction occurance because we already know that hyperuricemia is related to endothelial dysfunction, microvascular disease, and hypertension.

Objective: To identify the relationship between hyperuricemia and erectile dysfunction on hypertension patients in Bethesda Lempuyangwangi Hospital Yogyakarta.

Method: This is an observational study with cross-sectional design. The subjects are 88 hypertension patients, male, at least 18 years old, and registered as outpatient in Bethesda Lempuyangwangi Hospital Yogyakarta. Hyperuricemia is measured using uricase method, and erectile dysfunction is measured using IIEF-5 form.

Results: Variables with significant relationship to erectile dysfunction are hyperuricemia (OR=3,89; CI 95% 1,08-15,7; p=0,017), blood pressure (OR=6,84; CI 95% 2,35-20,6; p<0,001), and age (p<0,001). Logistic regression shows that hyperuricemia, age, and blood pressure are simultaneously affecting erectile dysfunction occurance, with good calibration (p=0,167) and discriminative level (0,8604).

Conclusion: There is significant relationship between hyperuricemia and erectile dysfunction on hypertension patients in Bethesda Lempuyangwangi Hospital Yogyakarta

Keywords


erectile dysfunction; hyperuricemia; hypertension; uric acid



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Journal of the Medical Sciences (Berkala Ilmu Kedokteran) by  Universitas Gadjah Mada is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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