Validity of narrow-band imaging (NBI) nasoendoscopy on nasopharyngeal carcinoma post therapy biopsy

https://doi.org/10.19106/JMedScie/005004201812

Veby Novri Yendri(1*), Camelia Herdini(2), Bambang Heriwiyanto(3)

(1) Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Universitas Islam Indonesia
(2) Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta
(3) Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta
(*) Corresponding Author

Abstract


Nasopharyngeal carcinoma (NPC) is the most common malignancy found in the head and neck. It is a unique head and neck cancer due to its radiosensitivity. Therefore, radiotherapy becomes the main modality of therapy. Post-treatment evaluation of NPC is important to assess prognosis. Biopsy that is the gold standard for the evaluation can be performed with a narrow-band imaging (NBI) nasoendoscopy guide. This study aimed to determine the validity of NBI nasoendoscopic examination of NPC post-treatment biopsy. This study was a cross-sectional design for all post-treatment NPC patients who would undergo response assessment at the Department of Otorhinolaryngology, Head and Neck Surgery, Dr. Sardjito General Hospital, Yogyakarta. A total 40 patients during May-June 2018 period who underwent examination sequentially. Biopsy examination was carried out with NBI nasoendoscopy guidance and the results of biopsy were performed histopathological examination. Forty patients showed the results of NBI nasoendoscopic validity on NPC biopsy after treatment included sensitivity (85.7%), specificity (87.8%), positive predictive value (60%), negative predictive value (96.6 %), positive trend ratio (7.07), negative trend ratio (0.16), and accuracy (87.5%). Postoperative NBI nasoendoscopy features appear homogeneous (75%) and inhomogenous (25%). In conclusion, NBI nasoendoscopic validity on postoperative NPC biopsy is good.

Keywords


validity – nasoendoscopy - narrow-band imaging - post-treatment nasopharyngeal carcinoma

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References

  1. Wei WI & Chua DTT. Nasopharyngeal carcinoma. In: Eibling DE & Newlands SD, editors. Bailey’s head and neck surgery otoloaryngology, 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2014.
  2. Jejayakumar A, Brickman TM, Jejayakumar A, Doerr T. Review of nasopharyngeal carcinoma. Ear, Nose Throat J, 2006; 83(3): 168-73.
  3. Ma J, Cao S. The epidemiology of nasopharyngeal carcinoma. In: Lu JJ, Cooper JS, Lee AWM, editors. Nasopharyngeal cancer multidisciplinary management. Heidelberg: Springer, 2010. http://dx.doi.org/10.1007/978-3-540-92810-2_1
  4. Tan EH, Soh LT, Ang PT. Chemotherapy of NPC. In: Nasopharyngeal carcinoma. Chong VFH & Tsao SY editors. Singapore: Loi Printing Pte Ltd, 1997.
  5. Prssad U, Wahid MIA, Jalaludin MA, Abdullah BJJ, Paramsothy M, Abdul-Kareem S. Long-term survival of nasoparyngeal carcinoma patients treated with adjuvant chemotherapy subsequent to conventional radical radiotherapy. Int J Radiat Oncol Bio Phys 2002; 53:648-55. http://dx.doi.org/10.1016/S0360-3016(02)02765-7
  6. Kentjono WA. Perkembangan terkini penatalaksanaan karsinoma nasofaring. Majalah Kedokteran Tropis Indonesia, 2003 14(2): 1-39.
  7. Suwito S. Radioterapi pada tumor ganas kepala dan leher (squamous cell ca). Dalam: Pendidikan Kedokteran Berkelanjutan III Ilmu Penyakit Telinga Hidung tenggorok-Kepala Leher. Surabaya: SMF Ilmu Penyakit THT-KL FK Unair/ RSUD Dr. Soetomo, 2002.
  8. Plank MJ & Sleeman BD. Tumour-induced angiogenesis: A review. J Theor Med 2003; 5:137-53. http://dx.doi.org/10.1080/10273360410001700843
  9. Nishida N, Yano H, Nishida T, Kamura T, Kojiro M. Angiogenesis in cancer. Vasc Health Risk Manag 2006; 2(3):213-9. http://dx.doi.org/10.2147/vhrm.2006.2.3.213
  10. 10. Lin YC, Wang WH. Narrow-band imaging for getecting early recurrent nasopharyngeal carcinoma. Head Neck 2009; 33(4):591-4. http://dx.doi.org/10.1002/hed.21310.
  11. Adham M, Kurniawan AN, Muhtadi AI, Roezin A, Hermani B, Gondhowiarjo S, et al. Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation. Chin J Cancer 2012; 31(4):185-96. http://dx.doi.org/10.5732/cjc.011.10328.
  12. Muto M, Nakane M, Katada C, Sano Y, Ohtsu A, Esumi H, et al. Squamous cell carcinoma in situ at oropharyngeal and hypopharyngeal mucosal sites. Cancer 2004; 101:1375-81. http://dx.doi.org/10.1002/cncr.20482
  13. Piazza C, Dessouky O, Peretti G, Cocco D, De Benedetto L, Nicolai P. Narrow-band imaging: a new tool for evaluation of head and neck squamous cell carcinomas. Review of literature. Acta Otorhinolaryngol Ital 2008; 28(2):49-54
  14. Fachiroh J, Prasetyanti PR, Paramita DK, Prasetyawati AT, Anggrahini DW, Haryana SM, et al. Dried-blood sampling for epstein-barr virus immunoglobulin G (IgG) and IgA serology in nasopharyngeal carcinoma screening. J Clin Microbiol 2008; 246(4):1374-80. http://dx.doi.org/10.1128/JCM.01368-07
  15. Fisher D, Knobf TM, Durivage HJ. Head and neck squamous cell carcinoma. In: Fischer DS, Durivge HJ, Knobf MT, Beaulieu N editors. The cancer chemotherapy handbook. 5th ed. St Louis Baltimore Boston: Mosby, 1997.
  16. Priyanto & Herdini C. Peran narrow band–imaging pada karsinoma nasofaring. Jurnal Kesehatan Andalas 2015; 4(1): 326-37
  17. Wang WH, Lin YC, Lee KF, Weng HH. Nasopharyngeal carcinoma detected by narrow-band imaging endoscopy. Oral Oncol 2011; 47:736-41. http://dx.doi.org/10.1016/j.oraloncology.2011.02.012
  18. Piazza C, Cocco D, Del Bon F, Mangili S, Nicolai P, Peretti G. Narrow band imaging and high definition television in the endoscopic evaluation of upper aero-digestive tract cancer. Acta Otorhinolaryngol Ita 2011; 31:70-75.
  19. Lukes P, Zabrodsky M, Plazk J, Chovanec M, Betka J, Foltynova E, et al. Narrow band imaging (NBI) – endoscopic method for detection of head and neck cancer. Endoscopy 2013; 75-87. http://dx.doi.org/10.5772/52738



DOI: https://doi.org/10.19106/JMedScie/005004201812

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Journal of the Medical Sciences (Berkala Ilmu Kedokteran) by  Universitas Gadjah Mada is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Based on a work at http://jurnal.ugm.ac.id/bik/.