Cranial unifocal langerhans cell histiocytosis in a female child: a difficult case with S-100 and CD1a immunonegativity
Hanggoro Tri Rinonce Sagiri Mangunsudirdjo Soeripto, J Bras
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Abstract
A 13-years old female child was carried to Dr. Sardjito General Hospital, Yogyakarta by her mother with chief complaint of a mass on her forehead. Since eight months prior to her visiting, she had a mass on her forehead which became larger slowly without tenderness and had no fever. Clinical examination revealed a well circumscribed mass, 3 cm in diameter, fixed, with rubbery consistency. The skull X-ray revealed a punch out lesion in frontal bone. The head CT scanning revealed a destruction of frontal bone. Clinical diagnosis of dermoid cyst was determined, excision and curettage was performed. Gross examination showed 2.5 cc fragmented tissue, brownish yellow, with rubbery consistency. A diagnosis of benign histiocytosis (Langerhans cell histiocytosis or non-Langerhans cell histiocytosis) of frontal bone was determined based on morphological and immunohistochemical examination. The aim of this presented article was to report a rare case of cranial unifocal Langerhans cell histiocytosis in a female child with S-100 and CD1a immunonegativity, and to discuss how to determine its diagnosis based on literature review. Key words: Langerhans cell histiocytosis - juvenile xanthogranuloma – reticulohistiocytoma - eosinophilic granuloma – S100 – CD1a
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Copyright (c) 2015 Hanggoro Tri Rinonce Sagiri Mangunsudirdjo Soeripto, J Bras
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