Risk factors of sensory hearing loss in nasopharyngeal carcinoma patients obtaining conventional radiotherapy

https://doi.org/10.19106/JMedSci005303202106

Odhi Anggani(1), Sagung Rai Indrasari(2), Feri Trihandoko(3), Anisa Haqul Khoiria(4), Ashadi Prasetyo(5*)

(1) Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital Yogyakarta, Indonesia.
(2) Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital Yogyakarta, Indonesia.
(3) Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital Yogyakarta, Indonesia.
(4) Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital Yogyakarta, Indonesia.
(5) Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital Yogyakarta, Indonesia.
(*) Corresponding Author

Abstract


Previous studies proven that cochlear hair cells’ death plays an important
role in sensorineural hearing loss due to radiation exposure. Other studies
compared the differences between the impact of conventional radiotherapy
(CRT) and intensity modulated radiation therapy (IMRT) on hearing loss in
patients with nasopharyngeal carcinoma. Although, few differences found
in some clinical manifestation, however no statistical analysis had been
carried out. The aim of study was to evaluate the risk of sensory hearing loss
in nasopharyngeal carcinoma patients who received CRT compared to IMRT.  
A case control study was performed on nasopharyngeal carcinoma patients
who received radiotherapy at Dr. Sardjito General Hospital, Yogyakarta.
The result of DPOAE between NPC patients who received CRT and IMRT was
compared in this study. Statistical analysis was performed using chi square
test and multivariate analysis. The result showed that patients who received
CRT significantly altered the risk for sensory hearing loss in the contralateral
ear as much as 11.2 times according to the multivariate analysis (CI 95%: 2.2 –
56.6; p=0.004). In conclusion, the risk of sensory hearing loss in patients with
nasopharyngeal carcinoma who received CRT is a greater compared to IMRT.

Keywords


radiotherapy; CRT; IMRT; sensory hearing loss; risk factors

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References


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DOI: https://doi.org/10.19106/JMedSci005303202106

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