Protective role of Nigella sativa oil against cisplatin-induced ototoxicity: a literature review

https://doi.org/10.19106/JMedSci005502202309

Donny Hendriyanto(1*), Helmi Helmi(2)

(1) Faculty of Medicine, Universitas Andalas, Padang
(2) Faculty of Agriculture, Universitas Andalas, Padang
(*) Corresponding Author

Abstract


Cisplatin is widely used for the chemotherapy of head and neck cancer. However, it has a significant ototoxicity. Nigella sativa has been scientifically proven to have numerous benefits included to prevent adverse effect of a drug. This literature review aimed to evaluate the protective role of N. sativa oil against cisplatin-induced ototoxicity. Relevant publications were searched  from PubMed and Google Scholar databases within the last 10 years. Ototoxicity due to cisplatin can occur through the intrinsic and extrinsic pathways. Cisplatin causes endoplasmic reticulum stress, DNA damage, increased reactive oxygen species (ROS) and inflammatory processes, resulting in increased apoptosis of cochlear outer hair cells. The active constituents of N. sativa including flavonoids, phenolics and thymoquinone can prevent the cisplatin-induced ototoxicity. Examination of endogenous antioxidants, antiapoptotic, and proinflammatory could be used as primary approach to evaluate the protective role of N. sativa against cisplatin-induced ototoxicity.


Keywords


cisplatin; nigella sativa; ototoxicity; protective role; side effect

Full Text:

PDF


References


1.Chang KW. Ototoxicity. In: Johnson JT, Rosen CA eds. Bailey’s Head and Neck Surgery, Otolaryngology, 5th ed. Philadelphia: Lippicott Williams & Wilkins, 2014: 2542-8.
2.Akdemir F, Gozeler M, Yildirim S, Askin S, Dortbudak M, Kiziltunc A. The effect of ferulic acid against cisplatin-induced ototoxicity. Med Science 2018; 7(3):528-31.
https://doi.org/10.5455/medscience.2018.07.8814
3.Esen E, Özdoğan F, Gürgen SG, Ozel HE, Baser S, Genc S, et al. Ginkgo biloba and lycopene are effective on cisplatin induced ototoxicity? J Int Adv Otol 2018; 14(1):23-6.
https://doi.org/10.5152/iao.2017.3137
4.Yurtsever KN, Baklaci D, Guler I, Kuzucu I, Kum RO, Ozhamam EU, et al. The Protective effect of platelet rich plasma against cisplatin-induced ototoxicity. J Craniofac Surg 2020; 31(5):506-9.
https://doi.org/10.1097/SCS.0000000000006645
5.Yu D, Gu J, Chen Y, Kang W, Wang X, Wu H. Current strategies to combat cisplatin-induced ototoxicity. Front Pharmacol 2020; 11:999.
https://doi.org/10.3389/fphar.2020.00999
6.Savitri E, Fitria D, Akil A, Daud D, Rasyid N, Kadir A. The effect of cisplatin chemotherapy on ototoxicity event in retinoblastoma patients. Int J Sci Healthc Res 2021; 6(1):89-94.
7.Hendriyanto D, Setiamika M, Primadewi N. The effect of ginkgo biloba against ototoxic hearing loss on advanced stage undifferentiated nasopharyngeal carcinoma receiving cisplatin chemotherapy. Int J Nasopharyngeal Carcinoma 2020; 2(02):44-6.
https://doi.org/10.32734/ijnpc.v2i02.3910
8.Tang Q, Wang X, Jin H, Mi Y, Liu L, Dong M, et al. Cisplatin-induced ototoxicity: Updates on molecular mechanisms and otoprotective strategies. Eur J Pharm Biopharm 2021; 163:60-71.
https://doi.org/10.1016/j.ejpb.2021.03.008
9.Lopes NB, Silva LAF, Samelli AG, Matas CG. Effects of chemotherapy on the auditory system of children with cancer: a systematic literature review. Rev CEFAC 2020; 22(2):e13919.
https://doi.org/10.1590/1982-0216/202022213919
10.Skarzynska MB, Krol B, Czajka L. Ototoxicity as a side-effect of drugs: literature review. J Hear Sci 2021; 10(2):9-19.
https://doi.org/10.17430/jhs.2020.10.2.1
11.Kim KH, Lee B, Kim YR, Kim MA, Ryu N, Jung DJ, et al. Evaluating protective and therapeutic effects of alpha-lipoic acid on cisplatin-induced ototoxicity. Cell Death Dis 2018; 9(8):827.
https://doi.org/10.1038/s41419-018-0888-z
12.Hazlitt RA, Min J, Zuo J. Progress in the development of preventative drugs for cisplatin-induced hearing loss. J Med Chem 2018; 61(13):5512-24.
https://doi.org/10.1021/acs.jmedchem.7b01653
13.Trendowski MR, El Charif O, Dinh Jr PC, Travis LB, Dolan ME. Genetic and modifiable risk factors contributing to cisplatin-induced toxicities. Clin Cancer Res 2019; 25(4):1147-55.
https://doi.org/10.1158/1078-0432.CCR-18-2244
14.Dhingra PL. Hearing loss. In: Dhingra PL & Dhingra S, eds. Disease of ear, nose and throat. 6th ed., Elsevier, New Delhi, 2014:33-4.
15.Tchounwou PB, Dasari S, Noubissi FK, Ray P, Kumar S. Advances in our understanding of the molecular mechanisms of action of cisplatin in cancer therapy. J Exp Pharmacol 2021; 13:303-28.
https://doi.org/10.2147/JEP.S267383
16.Kökten N, Eğilmez OK, Erinç M, Ekici AID, Serifler S, Yesilada E, et al. The protective effect of Nigella sativa oil against experimentally induced cisplatin ototoxicity: an animal study. J Int Adv Otol 2020; 16(3):346-52.
https://doi.org/10.5152/iao.2020.7761
17.Ardiana M, Pikir BS, Santoso A, Hermawan HO, Al-Farabi MJ. Effect of Nigella sativa supplementation on oxidative stress and antioxidant parameters: a meta-analysis of randomized controlled trials. Sci World J 2020; 2020:2390706.
https://doi.org/10.1155/2020/2390706
18.Habiburrohman D, Sukohar A. Aktivitas antioksidan dan antimikrobial pada polifenol teh hijau. Agromedicine Unila 2018; 5(2):587-91.
19.Paken J, Govender CD, Pillay M, Sewram V. Cisplatin-associated ototoxicity: a review for the health professional. J Toxicol 2016; 2016:1809394.
https://doi.org/10.1155/2016/1809394
20.Steyger PS. Mechanisms of aminoglycoside- and cisplatin-induced ototoxicity. Am J Audiol 2021; 30(3S):887-900.
https://doi.org/10.1044/2021_AJA-21-00006
21.Sheth S, Mukherjea D, Rybak LP, Ramkumar V. Mechanisms of cisplatin-induced ototoxicity and otoprotection. Front Cell Neurosci 2017; 11:338.
https://doi.org/10.3389/fncel.2017.00338
22.Mukherjea D, Dhukhwa A, Sapra A, Bhandari P, Woolford K, Franke J, et al. Strategies to reduce the risk of platinum containing antineoplastic drug-induced ototoxicity. Expert Opin Drug Metab Toxicol 2020; 16(10):965-82.
https://doi.org/10.1080/17425255.2020.1806235
23.Hodge SE, Lopez IA, Ishiyama G, Ishiyama A. Cisplatin ototoxicity histopathology. Laryngoscope Investig Otolaryngol 2021; 6(4):852-6.
https://doi.org/10.1002/lio2.608
24.Camet ML, Spence A, Hayashi SS, Wu N, Henry J, Sauerburger K, et al. Cisplatin ototoxicity: examination of the impact of dosing, infusion times, and schedules in pediatric cancer patients. Front Oncol 2021; 11:673080.
https://doi.org/10.3389/fonc.2021.673080
25.Patatt FSA, Gonçalves LF, de Paiva KM, Haas P. Ototoxic effects of antineoplastic drugs: a systematic review. Braz J Otorhinolaryngol 2022; 88(1):130-40.
https://doi.org/10.1016/j.bjorl.2021.02.008
26.Clemens E, de Vries ACH, Am Zehnhoff-Dinnesen A, Tissing WJ, Loonen JJ, Pluijm SF, et al. Hearing loss after platinum treatment is irreversible in noncranial irradiated childhood cancer survivors. Pediatr Hematol Oncol 2017; 34(2):120-9.
https://doi.org/10.1080/08880018.2017.1323985
27.Ralli M, Rolesi R, Anzivino R, Turchetta R, Fetoni AR. Acquired sensorineural hearing loss in children: current research and therapeutic perspectives. Acta Otorhinolaryngol Ital 2017; 37(6):500-8.
https://doi.org/10.14639/0392-100X-1574
28.Maksum R. Kemoterapi antikanker. In: Nirwanto MR & Afifah HN, eds. Mekanisme aksi molekuler antibiotik dan kemoterapi. Jakarta: Buku Kedokteran EGC, 2016; 177-200.
29.Dasari S, Bernard P. Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol 2014; 740:364-78.
https://doi.org/10.1016/j.ejphar.2014.07.025
30.Nejdl L, Kudr J, Moulick A, Hegerova D, Nedecky BR, Gumulec J, et al. Platinum nanoparticles induce damage to DNA and inhibit DNA replication. PLoS One 2017; 12(7):e0180798.
https://doi.org/10.1371/journal.pone.0180798
31.Qi L, Luo Q, Zhang Y, Jia F, Zhao Y, Wang F. Advances in toxicological research of the anticancer drug cisplatin. Chem Res Toxicol 2019; 32(8):1469-86.
https://doi.org/10.1021/acs.chemrestox.9b00204
32.Rébé C, Demontoux L, Pilot T, Ghiringhelli F. Platinum derivatives effects on anticancer immune response. Biomolecules 2020; 10(1):13.
https://doi.org/10.3390/biom10010013
33.Reis-sobreiro M, da Mota AT, Jardim C, Serre K. Bringing macrophages to the frontline against cancer : current immunotherapies targeting macrophages. Cells 2021; 10(9):2364.
https://doi.org/10.3390/cells10092364
34.Bracci L, Schiavoni G, Sistigu A, Belardelli F. Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer. Cell Death Differ 2014; 21(1):15-25.
https://doi.org/10.1038/cdd.2013.67
35.Galluzzi L, Buqué A, Kepp O, Zitvogel L, Kroemer G. Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol 2017; 17(2):97-111.
https://doi.org/10.1038/nri.2016.107
36.Gentilin E, Simoni E, Candito M, Cazzador D, Astolfi L. Cisplatin-induced ototoxicity: updates on molecular targets. Trends Mol Med 2019; 25(12):1123-32.
https://doi.org/10.1016/j.molmed.2019.08.002
37.Romano A, Capozza MA, Mastrangelo S, Muarizi P, Triarico S, Rolesi R, et al. Assessment and management of platinum-related ototoxicity in children treated for cancer. Cancers (Basel) 2020; 12(5):1266.
https://doi.org/10.3390/cancers12051266
38.Chandra L, Agus S, Sulaini P. Peran imunoekspresi Bcl-2 pada derajat histopatologik dan kedalaman invasi miometrium pada karsinoma endometrium tipe I. Maj Patol 2019; 28(1):10-16.
39.Zong S, Liu T, Wan F, Chen P, Luo P, Xiao H. Endoplasmic reticulum stress is involved in cochlear cell apoptosis in a cisplatin-induced ototoxicity rat model. Audiol Neurotol 2017; 22(3):160-8.
https://doi.org/10.1159/000480346
40.Nan B, Gu X, Huang X. The role of the reactive oxygen species scavenger agent, astaxanthin, in the protection of cisplatin-treated patients against hearing loss. Drug Des Devel Ther 2019; 13:4291-303.
https://doi.org/10.2147/DDDT.S212313
41.Moon SK, Woo JI, Lim DJ. Involvement of TNF-α and IFN-γ in inflammation-mediated cochlear injury. Ann Otol Rhinol Laryngol 2019; 128(6_suppl):8S-15.
https://doi.org/10.1177/0003489419837689
42.Brock P, Rajput K, Edwards L, Meijer A, Simpkin P, Hoetink A, et al. Cisplatin Ototoxicity in Children. Intech 2021; 1-25.
https://doi.org/10.5772/intechopen.96744
43.Amin B, Hosseinzadeh H. Black cumin (Nigella sativa) and its active constituent, thymoquinone: an overview on the analgesic and antiinflammatory effects. Planta Med 2016; 82(1-2):8-16.
https://doi.org/10.1055/s-0035-1557838
44.Bordoni L, Fedeli D, Nasuti C, Maggi F, Papa F, Wabitsch M, et al. Antioxidant and anti-inflammatory properties of nigella sativa oil in human pre-adipocytes. Antioxidants 2019; 8(2):51.
https://doi.org/10.3390/antiox8020051
45.Mukhtar H, Qureshi AS, Anwar F, Mumtaz MW, Marcu M. Nigella sativa L. seed and seed oil: potential sources of high-value components for development of functional foods and nutraceuticals/pharmaceuticals. J Essent Oil Res 2019; 31(4):1-13.
https://doi.org/10.1080/10412905.2018.1562388
46.Barutu YAP. Karakteristik enkapsulasi ekstrak biji jintan hitam (Nigella sativa) dan biji wijen (Sesamum indicum) sebagai sumber antioksidan potensial. Published online 2018.
47.Parwata MOA. Bahan ajar antioksidan. Kim Terap Progr Pascasarj Univ Udayana 2016;1-54.
48.Ighodaro OM, Akinloye OA. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria J Med 2018; 54(4):287-93.
https://doi.org/10.1016/j.ajme.2017.09.001
49.Islam MT. Biological activities and therapeutic promises of Nigella sativa L. Int J Pharm Sci Sci Res 2016.
https://doi.org/10.25141/2471-6782-2016-6.0237
50.Martins MJB, Batista AMA, Brito YNF, Soares PMG, Martins CS, Riberio RA, et al. Effect of remote ischemic preconditioning on systemic toxicity and ototoxicity induced by cisplatin in rats: role of TNF-α and nitric oxide. ORL J Otorhinolaryngol Relat Spec 2018; 79(6):336-46.
https://doi.org/10.1159/000485514
51.Ansari ZM, Nasiruddin M, Khan RA, Haque SF. Protective role of Nigella sativa in diabetic nephropathy : a randomized clinical trial. Saudi J Kidney Dis Transplant 2017; 28(1):9-14.
https://doi.org/10.4103/1319-2442.198093
52.Amanulloh M, Krisdayanti E. Jintan hitam sebagai imunomodulator dan antiinflamasi pada pasien asma. J Penelit Perawat Prof 2019; 1(1):115-20.
https://doi.org/10.37287/jppp.v1i1.32



DOI: https://doi.org/10.19106/JMedSci005502202309

Article Metrics

Abstract views : 746 | views : 790




Copyright (c) 2023 Donny Hendriyanto, Helmi Helmi

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

View My Stats

 

Creative Commons License
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) by  Universitas Gadjah Mada is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Based on a work at http://jurnal.ugm.ac.id/bik/.https://jh.unimed.ac.id/conference/docs/bonusx/ https://jh.unimed.ac.id/conference/docs/demox/ https://jh.unimed.ac.id/conference/docs/max/ https://jh.unimed.ac.id/conference/docs/pulsax/ https://jurnal.uinsu.ac.id/public/bonusx/ https://jurnal.uinsu.ac.id/public/demox/ https://jurnal.uinsu.ac.id/public/pulsax/ https://jurnal.uinsu.ac.id/public/qris/ https://journal.uny.ac.id/lib/demox/ https://journal.uny.ac.id/lib/max/ https://journal.uny.ac.id/lib/thaix/ https://journal.uny.ac.id/lib/gacorx/ https://celebica.uho.ac.id/styles/bonus/ https://celebica.uho.ac.id/styles/demo/ https://celebica.uho.ac.id/styles/gacor/ https://celebica.uho.ac.id/styles/thai/ https://icopis.untad.ac.id/wp-admin/js/xmax/ https://icopis.untad.ac.id/wp-admin/js/thai/ https://icopis.untad.ac.id/wp-admin/js/xgacor/ https://icopis.untad.ac.id/wp-admin/js/xdemo/ https://society.fisip.ubb.ac.id/config/xgacorx/ https://society.fisip.ubb.ac.id/config/xbonusx/ https://society.fisip.ubb.ac.id/config/xpulsax/ https://society.fisip.ubb.ac.id/config/xthai/ https://jurnal.unimed.ac.id/2012/xthai/ https://jurnal.unimed.ac.id/2012/xdemo/ https://jurnal.unimed.ac.id/2012/xgacor/ https://jurnal.unimed.ac.id/2012/xmax/ https://ihdnpress.ihdn.ac.id/wp-content/xgacor/ https://ihdnpress.ihdn.ac.id/wp-content/xpulsa/ https://ihdnpress.ihdn.ac.id/wp-content/xmax/ https://ihdnpress.ihdn.ac.id/wp-content/xthai/ https://jurnaltarbiyah.uinsu.ac.id/cache/bandar-s/ https://jurnaltarbiyah.uinsu.ac.id/cache/demo/ https://jurnaltarbiyah.uinsu.ac.id/cache/max/ https://jurnaltarbiyah.uinsu.ac.id/cache/bonus/ https://jurnal.unmer.ac.id/cache/thaix/ https://jurnal.unmer.ac.id/cache/bonusx/ https://jurnal.unmer.ac.id/cache/demox/ https://jurnal.unmer.ac.id/cache/max/ https://eoffice.uki.ac.id/upload/watermark/ https://student.binus.ac.id/wp-content/uploads/2024/00/1/ https://student.binus.ac.id/wp-content/uploads/2024/00/2/ https://myic.feb.unsoed.ac.id/wp-content/xbandart/ https://myic.feb.unsoed.ac.id/wp-content/xbonus/ https://myic.feb.unsoed.ac.id/wp-content/xpulsa/ https://myic.feb.unsoed.ac.id/wp-content/xtoto/ http://situr.feb.unsoed.ac.id/img/x777/ http://situr.feb.unsoed.ac.id/img/xbonus/ http://situr.feb.unsoed.ac.id/img/xdemo/ http://situr.feb.unsoed.ac.id/img/xtotos/ https://jurnal.staisumatera-medan.ac.id/thaix/ https://jurnal.staisumatera-medan.ac.id/totos/ https://jurnal.staisumatera-medan.ac.id/gacorx/ https://jurnal.staisumatera-medan.ac.id/bandars https://jurnal.fkip.unila.ac.id/sbonus/ https://jurnal.fkip.unila.ac.id/sgacor/ https://jurnal.fkip.unila.ac.id/spulsa/ https://jurnal.fkip.unila.ac.id/sthai/ http://ujian.bebras.polinema.ac.id/images/777/ http://ujian.bebras.polinema.ac.id/images/gacor/ http://ujian.bebras.polinema.ac.id/images/demo/ http://ujian.bebras.polinema.ac.id/images/thai/ https://jesr.eng.unila.ac.id/xgacor/ https://jesr.eng.unila.ac.id/xdemo/ https://jesr.eng.unila.ac.id/xthai/ https://jesr.eng.unila.ac.id/xmax/ http://digilib.fe.unj.ac.id/demo/ http://digilib.fe.unj.ac.id/bonus/ http://digilib.fe.unj.ac.id/pulsa/ http://digilib.fe.unj.ac.id/max/ https://jurnalmiqotojs.uinsu.ac.id/public/777/ https://jurnalmiqotojs.uinsu.ac.id/public/bonus/ https://jurnalmiqotojs.uinsu.ac.id/cache/demo/ http://jristam.uho.ac.id/styles/bonusx/ http://jristam.uho.ac.id/styles/demox/ http://jristam.uho.ac.id/styles/pulsax/ http://jristam.uho.ac.id/styles/thaix/ https://jurnalnasional.ump.ac.id/js/bonusx/ https://jurnalnasional.ump.ac.id/js/demox/ https://jurnalnasional.ump.ac.id/js/kambox/ https://fisip.ubb.ac.id/student/xkambo/ https://fisip.ubb.ac.id/student/xpulsa/ https://fisip.ubb.ac.id/student/xqris/ https://fisip.ubb.ac.id/student/xmax/ http://pub.unj.ac.id/docs/kambo/ http://pub.unj.ac.id/docs/demo/ http://pub.unj.ac.id/docs/max/ http://pub.unj.ac.id/docs/thai/ http://edm.fk.hangtuah.ac.id/public/bonus/ http://edm.fk.hangtuah.ac.id/public/demo/ http://edm.fk.hangtuah.ac.id/public/qris/ http://edm.fk.hangtuah.ac.id/public/totos/ https://endemis-journal.uho.ac.id/tools/zeusx/ https://endemis-journal.uho.ac.id/tools/ovox/ https://endemis-journal.uho.ac.id/tools/mahjongx/ https://endemis-journal.uho.ac.id/tools/qrisx/ https://ejournalagribisnis.uho.ac.id/styles/demox/ https://ejournalagribisnis.uho.ac.id/styles/gacorx/ https://ejournalagribisnis.uho.ac.id/styles/kambox/ https://ejournalagribisnis.uho.ac.id/styles/max/ https://portal.lomboktimurkab.go.id/demo/ https://portal.lomboktimurkab.go.id/gacor/ https://portal.lomboktimurkab.go.id/pulsa/ https://portal.lomboktimurkab.go.id/kambo/ https://websheffield.com/ https://skandinavskikutak.org/ https://andygolledgemusic.com/ https://servicewritingessay.net/ https://timelapsesf.com/ https://aaa-replica.com/ https://eztvshows.com/ https://everchicdesigns.com/ https://moviezucchinis.com/ https://concretecompanywestminsterco.com/ https://seasonalentertainmentllc.com/ https://emarket-solutions.com/ https://cruthucreative.com/ https://rmsinternationalschool.com/ https://redseasquall.com/ https://newstarhotelhanoi.com/