Protective effect of corncob extract cream on guinea pig (Cavia porcellus sp) skin pigmentation exposed to ultraviolet B (UVB) rays

https://doi.org/10.19106/JMedSci005503202302

Pasid Harlisa(1), Indah Wahyu Puspitasari(2), Suryani Yuliyanti(3*)

(1) Department of Dermatology and Venerology, Faculty of Medicine Universitas Islam Sultan Agung Semarang
(2) Department of Dermatology and Venerology, Faculty of Medicine Universitas Islam Sultan Agung Semarang
(3) Department of Dermatology and Venerology, Faculty of Medicine Universitas Islam Sultan Agung Semarang
(*) Corresponding Author

Abstract


Ultraviolet B (UVB) rays exposure causes skin inflammation and pigmentation lead to decrease skin lightness. Corncobs (Zea mays) contain flavonoids which can act as antioxidant to prevent free radicals and protect the skin pigmentation. This study aimed to evaluate the protective effect of corncob extract cream on skin pigmentation exposed to UVB rays. This pre-posttest control group study was applied to 25 guinea pigs (Cavia porcellus sp) randomly divided into five groups. Corncob extract cream was given every day 20 min before and 4 h after UVB exposure. The UVB exposure total dose was 780 mJ/cm2. Mexameter examination was carried out on the 1st day and 28th day after treatment. There were significantly differences in the lightness level and the mean melanin index (MI) difference of guinea pigs before and after intervention on various groups (p<0.05). No significantly different of the MI between pre- and post-treatment was observed on normal control group (0.22) and negative control group (-1.06) (p>0.05). However, significantly different of the MI was observed on positive control group (-4.01), corncob 40% group (-2.72), and corncob 30% group (-2.03) (p<0.05). In conclusion, corncob extract cream can inhibit the skin pigmentation due UVB rays exposure.

Keywords


skin brightness, corn cobs, UV-B rays.

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References


1. Winarni RW. Women’s beauty representation in advertising. Deiksis 2010; 2(2):134-52.
2. Pratiwi S, Husni P. Potensi penggunaan fitokonstituen tanaman Indonesia sebagai bahan aktif tabir surya. Farmaka 2017; 15(4):18-25.
https://doi.org/10.24198/jf.v15i4.14581.g7430
3. BPOM RI. Laporan tahunan Badan Pengawas Obat dan Makanan 2019. Jakarta: Badan Pengawas Obat dan Makanan, Republik Indonesia.
4. World Health Organization. Mercury in skin lightening products public health and environment. Preventing DiseaseThrough Healthy Environment. 2019. World Health Organization. https://apps.who.int/iris/handle/10665/330015.
5. Astuti DW, Prasetya HR, Irsalina D. Hydroquinone identification in whitening creams sold at minimarkets in Minomartini, Yogyakarta. J Agromedicine Med Sci 2016; 2(1):13-20. https://doi.org/10.19184/ams.v2i1.1859
6. Lumempouw L, Suryanto E, Paendong J. Aktivitas anti UVB ekstrak fenolik dari tongkol jagung (Zea mays L.). J MIPA 2012; 1(1):1-4.
https://doi.org/10.35799/jm.1.1.2012.422
7. Susanty, Bachdim F. Perbandingan metode ekstraksi maserasi dan refluks terhadap kadar fenolik dari ekstrak tongkol jagung (Zea mays L.). Konversi 2012; 5(2):87-93.
https://doi.org/10.24853/konversi.5.2.87-92
8. Suryanto E, Momuat LI, Yudistira A, Wehantouw F. The evaluation of singlet oxygen quenching and sunscreen activity of corn cob extract. Indones J Pharm 2013; 24(4):267-76.
http://dx.doi.org/10.14499/indonesianjpharm0iss0pp267-276
9. Kusriani H, Marliani L, Apriliani E. Antioxidant and sunscreen activities of corn cob and corn silk of Zea mays. Indon J Pharm Sci Technol 2017; 4(1):1-17.
https://doi.org/10.15416/ijpst.v4i1.10428
10. Saleh LP, Suryanto E, Yudistira A. Aktivitas antioksidan dari ekstrak tongkol jagung (Zea mays L.). Pharmacon 2012; 1(2):20-4.
https://doi.org/10.35799/pha.1.2012.465
11. Hastiningsih I, Pangkahila WI, De Putra Wiraguna AAG, Aman IGM, Pangkahila JA, Iswari I, et al. Ethanol extract cream of jackfruit tree bark (Arthocarpus heterophilus) is equally effective with hydroquinone cream on preventing the increase of melanin on guinea pigs skin (Cavia porcelus) exposed to ultraviolet B ray. J Glob Pharma Technol 2019; 11(4):280-5.
12. Pillaiyar T, Manickam M, Jung SH. Recent development of signaling pathways inhibitors of melanogenesis. Cell Signal 2017; 40:99-115.
https://doi.org/10.1016/j.cellsig.2017.09.004
13. Jablonski NG, Chaplin G. Human skin pigmentation as an adaptation to UV radiation. Proc Natl Acad Sci U S A 2010; 107(Suppl 2):8962-8.
https://doi.org/10.1073/pnas.0914628107
14. Kolbe L, Mann T, Gerwat W, Batzer J, Ahlheit S, Scherner C, et al. 4-N-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation. J Eur Acad Dermatol Venereol 2013; 27(Suppl 1):19-23.
https://doi.org/10.1111/jdv.12051
15. Schwartz C, Jan A, Zito PM. Hydroquinone. In: NCBI Bookshelf [Internet]. StatPearls Publishing; 2022. p. 7–11.
https://www.ncbi.nlm.nih.gov/books/NBK539693/?report=printable
16. Wardhani PH, Rahmadewi. Pilihan terapi hiperpigmentasi pascainflamasi pada kulit berwarna. Berkala Ilmu Kesehatan Kulit dan Kelamin 2016; 28(3):1-8.
17. Safitri CINH, Jubaidah L. Formulasi dan uji mutu fisik sediaan lotion ekstrak kulit buah jagung (Zea mays L.). J Insa Farm Indones 2019; 2(2):175-84.
https://doi.org/10.36387/jifi.v2i2.394
18. Suryanto E, Momuat LI. Isolasi dan aktivitas antioksidan fraksi dari ekstrak tongkol jagung. Agritech 2017; 37(2):139-47.
https://doi.org/10.22146/agritech.27537
19. Sagala Z, Pratiwi RW, Azmi NU. Uji aktivitas inhibisi terhadap enzim tirosinase dari ekstrak etanol daun pepaya (Carica papaya L.) secara in vitro. J Penelit Farm Indones 2019; 7(2):34-8
20. Trifena, Elya B, Wih WL, Purwoningsih EH, Jufri M. Analisis uji in vitro dan in vivo ekstrak kombinasi kulit manggis (Garcinia mangostana L.) dan pegagan (Centella asiatica L,) sebagai krim antioksidan. [Tesis]. Jakarta: FMIPA UI, 2012.
https://lib.ui.ac.id/detail?id=20297606
21. You YJ, Wu PY, Liu YJ, Hou CW, Wu CS, Wen KC, et al. Sesamol inhibited ultraviolet radiation-induced hyperpigmentation and damage in C57BL/6 mouse skin. Antioxidants 2019; 8(7):207.
https://doi.org/10.3390/antiox8070207




DOI: https://doi.org/10.19106/JMedSci005503202302

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