Synthesis, Spectral Identification, Thermal Studies, Antioxidant Properties, and Biological Effects for Some Metal Ion Complexes with New Schiff Base Ligand

Aseel Hikmat Abad Al-Ameer; Naser Shaalan

doi:10.22146/ijc.102636

Synthesis, Spectral Identification, Thermal Studies, Antioxidant Properties, and Biological Effects for Some Metal Ion Complexes with New Schiff Base Ligand

https://doi.org/10.22146/ijc.102636

Aseel Hikmat Abad Al-Ameer^(1*), Naser Shaalan⁽²⁾

(1) Department of Chemistry, College of Science, University of Baghdad, Baghdad, Al Jadriya 10070, Iraq
(2) Department of Chemistry, College of Science for Women, University of Baghdad, Al Jadriya 10070, Iraq
(*) Corresponding Author

Abstract

The tetradentate N₂O₂ Schiff base ligand, which is produced via the condensation reaction of 2-hydroxynaphthaldehyde with phthalohydrazide, is prepared in this work with a fair yield. The prepared ligand was characterized using a microanalysis technique (C.H.N), UV-vis, FTIR, ¹H-,¹³C-NMR, mass spectrometry, and thermal gravimetric analysis (TGA). New complexes were synthesized by a reaction between ligand (N'1E,N'2Z)-N'1,N'2-bis((1-hydroxynaphthalen-2yl)methylene)phthalohydrazide and metal chloride of Co⁺², Ni⁺², and Zn⁺² ions in absolute ethanol. The present complexes are also characterized by techniques such as C.H.N, UV-vis, FTIR, TGA, molar conductivity, atomic absorption, and magnetic moment measurements. The in vitro antimicrobial activity of the prepared compounds was tested against two Gram-positive bacteria (Staphylococcus aureus and Bacillus) and two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), as well as Candida albicans as a fungal species, by diffusion technique in addition to antioxidant properties. The spectroscopy measurement showed that the ligand coordinated with the metal ion as a tetradentate ligand via oxygen and nitrogen in addition to the chloride ion to form octahedral shapes. All compounds under study had a positive effect against antibacterial, antifungal, and antioxidant activities.

Keywords

condensation reaction; antioxidant activities; antimicrobial activity; tetradentate

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DOI: https://doi.org/10.22146/ijc.102636