Recent Studies on Optical and Electrochemical Sensors for On-Site Detection of Methamphetamine
Hussain Alessa(1*), Sulafa Nassar(2)
(1) Department of Chemistry, Faculty of Science, Umm Al-Qura University, Makkah 24230, Saudi Arabia
(2) Department of Chemistry, Faculty of Science, Umm Al-Qura University, Makkah 24230, Saudi Arabia
(*) Corresponding Author
Abstract
Universally, the usage of unlawful drugs is one of the serious matters that reduces the prosperity and health of the users and communities. Methamphetamine (MAPA) is one of the illicit drugs that is fabricated in clandestine laboratories. It is considered one of the most harmful drugs spreading among youths around the globe. Therefore, the development of sophisticated sensing technology for its rapid and accurate detection is required. Sensors consist mainly of a recognition element, a transduction element and a signal processor for detecting MAPA and recording its chemical concentration. Different chemical sensors, such as optical, magnetic, thermal and electrochemical sensors have been utilized. They differ in the working mechanism and the type of measured signal. The aim of this review is to provide a summary of the up-to-date advancements in optical and electrochemical sensors that have been used for MAPA detection in different samples, particularly from 2012 to 2025.
Keywords
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[1] Shakeri, J., Farnia, V., Davarinejad, O., Salemi, S., Golshani, S., Rahami, B., Alikhani, M., and Hookari, S., 2020, Distress tolerance in methamphetamine and opium abusers with non-drug abuser (A comparative analysis), Clin. Epidemiol. Global Health, 8 (2), 513–518.
[2] Protti, M., Mandrioli, R., Gonzalez-Rodriguez, J., and Mercolini, L., 2022, Enantioselective analysis of the methamphetamine precursors ephedrine and pseudoephedrine by capillary electrokinetic chromatography using cyclodextrins as chiral selectors, J. Chromatogr. Open, 2, 100032.
[3] Markowitz, J.S., and Patrick, K.S., 2017, The clinical pharmacokinetics of amphetamines utilized in the treatment of attention-deficit/hyperactivity disorder, J. Child Adolesc. Psychopharmacol., 27 (8), 678–689.
[4] Prakash, M.D., Tangalakis, K., Antonipillai, J., Stojanovska, L., Nurgali, K., and Apostolopoulos, V., 2017, Methamphetamine: Effects on the brain, gut and immune system, Pharmacol. Res., 120, 60–67.
[5] Wearne, T.A., and Cornish, J.L., 2018, A comparison of methamphetamine-induced psychosis and schizophrenia: A review of positive, negative, and cognitive symptomatology, Front. Psychiatry, 9, 491.
[6] Ballester, J., Valentine, G., and Sofuoglu, M., 2017, Pharmacological treatments for methamphetamine addiction: Current status and future directions, Expert Rev. Clin. Pharmacol., 10 (3), 305–314.
[7] Akhgari, M., Mobaraki, H., and Etemadi-Aleagha, A., 2017, Histopathological study of cardiac lesions in methamphetamine poisoning-related deaths, Daru, J. Pharm. Sci., 25 (1), 5.
[8] Smith, L.M., Paz, M.S., LaGasse, L.L., Derauf, C., Newman, E., Shah, R., Arria, A., Huestis, M.A., Haning, W., Strauss, A., Della Grotta, S., Dansereau, L.M., Neal, C., and Lester, B.M., 2012, Maternal depression and prenatal exposure to methamphetamine: Neurodevelopmental findings from the infant development, environment, and lifestyle (ideal) study, Depression Anxiety, 29 (6), 515–522.
[9] United Nations Office on Drugs and Crime, 2022, World Drug Report 2022, United Nations, Vienna, Austria.
[10] Al-Asmari, A.I., 2021, Methamphetamine-related postmortem cases in Jeddah, Saudi Arabia, Forensic Sci. Int., 321, 110746.
[11] Barnes, C., Madaras, S., Pigou, P.E., Johnston, M.R., and Kirkbride, K.P., 2019, Origins of N-formylmethamphetamine and N-acetylmethamphetamine in methamphetamine produced by the hydriodic acid and red phosphorus reduction of pseudoephedrine, Forensic Chem., 13, 100158.
[12] Shekari, A., Akhgari, M., Jokar, F., and Mousavi, Z., 2016, Impurity characteristics of street methamphetamine crystals seized in Tehran, Iran, J. Subst. Use, 21 (5), 501–505.
[13] Biddle, T.J., Wermuth, U.D., Loughlin, W.A., Cresswell, S.L., and White, A.R., 2022, Potential forensic markers from synthetic pathways to 1-phenyl-2-propanone from uncontrolled and controlled substances, Forensic Chem., 28, 100410.
[14] Toske, S.G., and McKibben, T.D., 2022, Monitoring methamphetamine in the United States: A two‐decade review as seen by the DEA methamphetamine profiling program, Drug Test. Anal., 14 (3), 416–426.
[15] Ciesielski, AL., Green, M.K., and Wagner, J.R., 2020, Characterization of one pot methamphetamine laboratories using GC-MS and LC-MS/MS, Forensic Chem., 19, 100244.
[16] Ramli, F.F., Rejeki, P.S., Ibrahim, N.I., Abdullayeva, G., and Halim, S., 2025, A mechanistic review on toxicity effects of methamphetamine, Int. J. Med. Sci., 22 (3), 482–507.
[17] Wang, T., Xu, C., Xu, S., Gao, L., Blaženović, I., Ji, J., Wang, J., and Sun, X., 2021, Untargeted metabolomics analysis by gas chromatography/time‐of‐flight mass spectrometry of human serum from methamphetamine abusers, Addict. Biol., 26 (6), e13062.
[18] Shin, I., Choi, H., Kang, S., Kim, J., Park, Y., and Yang, W., 2021, Detection of l-methamphetamine and l-amphetamine as selegiline metabolites, J. Anal. Toxicol., 45 (1), 99–104.
[19] Pérez-Fernández, V., Mainero Rocca, L., Tomai, P., Fanali, S., and Gentili, A., 2017, Recent advancements and future trends in environmental analysis: Sample preparation, liquid chromatography and mass spectrometry, Anal. Chim. Acta, 983, 9–41.
[20] Kawde, A.N., Baig, N., and Sajid, M., 2016, Graphite pencil electrodes as electrochemical sensors for environmental analysis: A review of features, developments, and applications, RSC Adv., 6 (94), 91325–91340.
[21] Shaw, L., and Dennany, L., 2017, Applications of electrochemical sensors: Forensic drug analysis, Curr. Opin. Electrochem., 3 (1), 23–28.
[22] Bor, G., Bulut, U., Man, E., Balaban Hanoglu, S., Evran, S., and Timur, S., 2022, Synthetic antibodies for methamphetamine analysis: Design of high affinity aptamers and their use in electrochemical biosensors, J. Electroanal. Chem., 921, 116686.
[23] Khorablou, Z., Shahdost-Fard, F., and Razmi, H., 2023, High sensitive detection of methamphetamine by high-performance aptasensing platform based on nickel oxide nanoparticles anchored on MXene, Microchem. J., 193, 109216.
[24] Johannessen, S.I., and Tomson, T., 2006, Pharmacokinetic variability of newer antiepileptic drugs, Clin. Pharmacokinet., 45 (11), 1061–1075.
[25] Wissenbach, D.K., Binz, T.M., and Steuer, A.E., 2023, Advances in testing for sample manipulation in clinical and forensic toxicology—part B: Hair samples, Anal. Bioanal. Chem., 415 (21), 5117–5128.
[26] Shu, I., Alexander A., Jones, M., Jones, J., and Negrusz, A., 2016, Determination of methamphetamine enantiomer composition in human hair by non-chiral liquid chromatography–tandem mass spectrometry method, J. Chromatogr. B, 1028, 145–152.
[27] McKenzie, E.J., Miskelly, G.M., and Butler, P.A.G., 2013, Dynamic solid phase microextraction analysis for airborne methamphetamine: Quantitation using isotopically substituted methamphetamine, Anal. Methods, 5, 4391–4396.
[28] Dos Santos, B.P., Scherer, J.N., Viola, P.P., Govoni, B., Vasconcelos, M., Dalanhol, C.S., Borges, G.R., de Gouveia, G.C., Arantes, A.C.F., Martins, A.F., da Costa, J.L., Huestis, M.A., and Pechansky, F., 2025, Oral fluid device performance in identifying amphetamine, methamphetamine, and cocaine use in Brazilian drivers, J. Anal. Toxicol., 49 (7), 450–459.
[29] Tani, N., Oritani, S., Ono, M., and Ishikawa, T., 2025, Forensic significance of quantitatively analyzing methamphetamine in male reproductive organs, Leg. Med., 75, 102618.
[30] Argente-García, A., Jornet-Martínez, N., Herráez-Hernández, R., and Campíns-Falcó, P., 2016, A solid colorimetric sensor for the analysis of amphetamine-like street samples, Anal. Chim. Acta, 943, 123–130.
[31] Wright, J., Kenneally, M., Ross, K., and Walker, S., 2020, Environmental methamphetamine exposures and health effects in 25 case studies, Toxics, 8 (3), 61.
[32] Russell, M., Nicolle, S., Mayo, E., and Chappell, A., 2022, Deposition of methamphetamine residues produced by simulated smoking, Forensic Sci. Int., 338, 111407.
[33] Gao, J., Culshaw, P., Ngo, H.K.T., Howell, J., Le, H.H.T.C., Yang, M., and Thai, P.K., 2023, Methamphetamine contamination in residential properties and their remediation in Queensland, Australia, Forensic Sci. Int.: Rep., 7, 100311.
[34] Kerry, G.L., Ross, K.E., Walker, G.S., and Wright, J., 2025, Determining extent and distribution of methamphetamine in cars: Air vs. surface vs. fabrics, Forensic Chem., 42, 100628.
[35] Farst, K., and Bolden, B.B., 2012, Substance-exposed infants and children: forensic approach, Clin. Pediatr. Emerg. Med., 13 (3), 221–228.
[36] Morrison, G., Shakila, N.V., and Parker, K., 2015, Accumulation of gas‐phase methamphetamine on clothing, toy fabrics, and skin oil, Indoor Air, 25 (4), 405–414.
[37] Krakowiak, R.I., Poklis, J.L., and Peace, M.R., 2019, The analysis of aerosolized methamphetamine from E-cigarettes using high resolution mass spectrometry and gas chromatography mass spectrometry, J. Anal. Toxicol., 43 (8), 592–599.
[38] Bagheri, H., Zavareh, A.F., and Koruni, M.H., 2016, Graphene oxide assisted electromembrane extraction with gas chromatography for the determination of methamphetamine as a model analyte in hair and urine samples, J. Sep. Sci., 39 (6), 1182–1188.
[39] Miraee, S.N., Qomi, M., Shamshiri, F., and Raoufi, P., 2014, Hollow-fiber liquid-phase microextraction followed by high performance liquid chromatography for the determination of trace amounts of methylphenidate hydrochloride in biological fluids, Biomed. Pharmacol. J., 7 (2), 715–725.
[40] Bahmanabadi, L., Akhgari, M., Jokar, F., and Sadeghi, H.B., 2017, Quantitative determination of methamphetamine in oral fluid by liquid–liquid extraction and gas chromatography/mass spectrometry, Hum. Exp. Toxicol., 36 (2), 195–202.
[41] Radwan, R.A., Abouzied, N.F., Mora, A., Hassan, A.M., and Abd Elkader, M.M., 2025, Study of methamphetamine abuse among drug abuse positive cases attending Sohag clinical toxicology laboratory by new validated HPLC-DAD method, Ain Shams J. Forensic Med. Clin. Toxicol., 44, 100–118.
[42] Gracia-Lor, E., Pérez-Valenciano, A., De Oro-Carretero, P., Ramírez-García, L., Sanz-Landaluze, J., and Martín-Gutiérrez, M.J., 2024, Consumption of illicit drugs and benzodiazepines in six Spanish cities during different periods of the COVID-19 pandemic, Sci. Total. Environ., 935, 173356.
[43] Kumazawa, T., Hasegawa, C., Hara, K., Uchigasaki, S., Lee, X.P., Seno, H., Suzuki, O., and Sato, K., 2012, Molecularly imprinted solid-phase extraction for the selective determination of methamphetamine, amphetamine, and methylenedioxyphenylalkylamine designer drugs in human whole blood by gas chromatography-mass spectrometry, J. Sep. Sci., 35 (5-6), 726–733.
[44] Rezazadeh, M., Yamini, Y., and Seidi, S., 2015, Application of a new nanocarbonaceous sorbent in electromembrane surrounded solid phase microextraction for analysis of amphetamine and methamphetamine in human urine and whole blood, J. Chromatogr. A, 1396, 1–6.
[45] Kala, K.L., Anbuchezhiyan, G., Pingili, K., Singh, P.K., Vel, V.M., Yusuf, K., Aljuwayid, A.M., Islam, M.A., and Christopher, D., 2023, Employing a carbon-based nanocomposite as a diffusive solid-phase extraction adsorbent for methamphetamine for therapeutic purposes, Adsorp. Sci. Technol., 2023, 8650678.
[46] Farasati, Far, B., Naimi-Jamal, M.R., Jahanbakhshi, M., Mohammed, H.T., Altimari, U.S., and Ansari, J., 2022, Poly(3-thienylboronic acid) coated magnetic nanoparticles as a magnetic solid-phase adsorbent for extraction of methamphetamine from urine samples, J. Dispersion Sci. Technol., 44 (14), 2723–2733.
[47] Ghalebi, M., Hamidi, S., Nemati, M., Sheykizadeh, S., Lotfipour, F., Alipour, Ghorbani, N., and Farjami, A., 2022, Development of an efficient and sensitive magnetic dispersive solid-phase extraction technique for preconcentration of amphetamine and methamphetamine determined by high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry in sports supplements, Anal. Bioanal. Chem. Res., 9 (4), 431–442.
[48] Simarro-Gimeno, C., Garlito, B., Pitarch, E., and Hernández, F., 2023, Evaluation of direct sample injection as a fast, no-sample handling, approach for the LC-MS/MS monitoring of pharmaceuticals in different water matrices, Microchem. J., 193, 108985.
[49] Jørgenrud, B., McQuade, T., Maria, M.H., Nilsson, G., and Berg, T., 2025, Buffer-free high pH mobile phase LC-MS/MS for determination of the alcohol biomarker phosphatidylethanol 16: 0/18: 1 and 20 drugs and metabolites in whole blood, Talanta, 282, 126964.
[50] Baz-Lomba, A., Löve, A.S.C., Reid, M.J., Ólafsdóttir, K., and Thomas, K.V., 2018, A high-throughput solid-phase microextraction and post-loop mixing large volume injection method for water samples, J. Chromatogr. A, 1531, 32–38.
[51] Boogaerts, T., Quireyns, M., Maes, F., Laimou‐Geraniou, M., Van Wichelen, N., Heath, E., Pussig, B., Aertgeerts, B., Covaci, A., and van Nuijs, A.L.N., 2023, Optimization, validation and application of a high‐throughput 96‐well elution protocol for the quantification of psychoactive substances in influent wastewater, Drug Test. Anal., 15 (2), 240–246.
[52] Vosough, M., Mohamedian, H., Salemi, A., and Baheri, T., 2015, Multivariate curve resolution-assisted determination of pseudoephedrine and methamphetamine by HPLC-DAD in water samples, J. Chromatogr. Sci., 53 (2), 233–239.
[53] Abdulrahman, S.K., Qassim, A.W., and Rasheed, A.S., 2022, The evaluation of two zwitterionic hydrophilic interaction liquid chromatography materials for the rapid separation of methamphetamine and muscimol pharmaceuticals, Int. J. Drug Delivery Technol., 12 (2), 1882–1886.
[54] Nourani, N., Javadzadeh, Y., Shayanfar, A., Taghvimi, A., Bavili-Tabrizi, A., and Dastmalchi, S., 2024, Extraction of methamphetamine and pseudoephedrine by modified graphene oxide solid phase extraction method coupled to HPLC-UV in urine sample, BMC Chem., 18 (1), 216.
[55] Zhang, S., Cui, Y., Sun, J., Xi, Y., Zhang, C., and Tang, J., 2015, Sensitive magnetic solid-phase microextraction based on oxide multi-walled carbon-nanotubes for the determination of methylamphetamine and ketamine in human urine and blood, Anal. Methods, 7 (10), 4209–4215.
[56] Taghvimi, A., and Hamishehkar, H., 2017, Carbon coated magnetic nanoparticles as a novel magnetic solid phase extraction adsorbent for simultaneous extraction of methamphetamine and ephedrine from urine samples, J. Chromatogr. B, 1041-1042, 113–119.
[57] Haeri, S., Abbasi, S., and Sajjadifar, S., 2017, Bio-dispersive liquid liquid microextraction based on nano rhaminolipid aggregates combined with magnetic solid phase extraction using Fe3O4@PPy magnetic nanoparticles for the determination of methamphetamine in human urine, J. Chromatogr. B., 1063, 101–106.
[58] Lu, Q., Guo, H., Zhang, Y., Tang, X., Lei, W., Qi, R., Chu, J., Li, D., and Zhao, Q., 2020, Graphene oxide-Fe3O4 nanocomposite magnetic solid phase extraction followed by UHPLC-MS/MS for highly sensitive determination of eight psychoactive drugs in urine samples, Talanta, 206, 120212.
[59] Akramipour, R., Fattahi, N., Pirsaheb, M., and Gheini, S., 2016, Combination of counter current salting-out homogenous liquid–liquid extraction and dispersive liquid–liquid microextraction as a novel microextraction of drugs in urine samples, J. Chromatogr. B, 1012-1013, 162–168.
[60] Chen, X., 2015, Analysis of methamphetamine in human urine using ionic liquid dispersive liquid-phase microextraction combined with HPLC, Chromatographia, 78 (7), 515–520.
[61] Wang, R., Qi, X., Zhao, L., Liu, S., Gao, S., Ma, X., and Deng, Y., 2016, Ionic‐liquid‐based dispersive liquid–liquid microextraction coupled with high‐performance liquid chromatography for the forensic determination of methamphetamine in human urine, J. Sep. Sci., 39 (13), 2444–2450.
[62] Alizadeh, N., Jafari, M., and Mohammadi, A., 2009, Headspace-solid-phase microextraction using a dodecylsulfate-doped polypyrrole film coupled to ion mobility spectrometry for analysis methyl tert-butyl ether in water and gasoline, J. Hazard. Mater., 169 (1-3), 861–867.
[63] McKenzie, E.J., Miskelly, G.M., and Butler, P.A.G., 2013, Detection of methamphetamine in indoor air using dynamic solid phase microextraction: A supplementary method to surface wipe sampling, Anal. Methods, 5 (20), 5418–5424.
[64] Nair, M.V., and Miskelly, G.M., 2016, Capillary microextraction: A new method for sampling methamphetamine vapour, Forensic Sci. Int., 268, 131–138.
[65] Nair, M.V., and Miskelly, G.M., 2019, Determination of airborne methamphetamine via capillary microextraction of volatiles (CMV) with on-sorbent derivatisation using o-pentafluorobenzyl chloroformate, Forensic Chem., 14, 100161.
[66] Dobos, A., Hidvégi, E., and Somogyi, G.P., 2012, Comparison of five derivatizing agents for the determination of amphetamine-type stimulants in Human urine by extractive acylation and gas chromatography–mass spectrometry, J. Anal. Toxicol., 36 (5), 340–344.
[67] Pires, B., Simão, A., Rosado, T., Barroso, M., and Gallardo, E., 2025, Determination of amphetamines in hair samples using microextraction by packed sorbent and gas chromatography–mass spectrometry, Drug Test. Anal., 17 (6), 761–771.
[68] Kwon, N.H., Lee, Y.R., Kim, H.S., Cheong, J.C., and Kim, J.Y., 2019, Hybrid solid-phase extraction for selective determination of methamphetamine and amphetamine in dyed hair by using gas chromatography–mass spectrometry, Molecules, 24 (13), 2501.
[69] Han, E., Yang, H., Seol, I., Park, Y., Lee, B., and Song, J.M., 2013, Segmental hair analysis and estimation of methamphetamine use pattern, Int. J. Leg. Med., 127 (2), 405–411.
[70] Alawi A., Dhabbah A.M., Morrison C., Ben-Jaber S., AlAngari W.A., Bin Jassas M., and Badjah‑Hadj‑Ahmed, Y., 2023, Indirect chiral separation of crystal methamphetamine seized in Saudi Arabia using GC-MS, Aust. J. Forensic Sci., 55 (6), 731–744.
[71] Djozan, D., Farajzadeh, M.A., Sorouraddin, S.M., and Baheri, T., 2012, Determination of methamphetamine, amphetamine and ecstasy by inside-needle adsorption trap based on molecularly imprinted polymer followed by GC-FID determination, Microchim. Acta, 179 (3), 209–217.
[72] Khajeamiri, A.R., Faizi, M., Sohani, F., Baheri, T., and Kobarfard, F., 2012, Determination of impurities in illicit methamphetamine samples seized in Iran, Forensic Sci. Int., 217 (1), 204–206.
[73] Mostafa, I.M., Meng, C., Dong, Z., Lou, B., and Xu, G., 2022, Potentiometric sensors for the determination of pharmaceutical drugs, Anal. Sci., 38 (1), 23–37.
[74] Al‐Hetlani, E., 2013, Forensic drug analysis and microfluidics, Electrophoresis, 34 (9-10), 1262–1272.
[75] Ammen, E.W., and Al-Bayati, Y.K., 2024, Determination of chlorpromazine using molecular imprinting polymers in different sample matrices, Indones. J. Chem., 24 (6), 1870–1882.
[76] Mao, K., Zhang, H., Wang, Z., Cao, H., Zhang, K., Li, X., and Yang, Z., 2020, Nanomaterial-based aptamer sensors for arsenic detection, Biosens. Bioelectron., 148, 111785.
[77] Krauss, S.T., Remcho, T.P., Lipes, S.M., Aranda, R., Maynard, H.P., Shukla, N., Li, J., Tontarski, R.E., and Landers, J.P., 2016, Objective method for presumptive field-testing of illicit drug possession using centrifugal microdevices and smartphone analysis, Anal. Chem., 88 (17), 8689–8697.
[78] Guo, J., Tian, S., Liu, K., and Guo, J., 202i, IoT-enabled fluorescence sensor for quantitative KET detection and anti-drug situational awareness, IEEE Trans. NanoBiosci., 20 (1), 2–8.
[79] Fan, L., Yang, J., Wu, J., Li, F., Yan, W., Tan, F., Zhang, M., Draz, M.S., Han, H., and Zhang, P., 2022, Deeply-dyed nanobead system for rapid lateral flow assay testing of drugs at point-of-care, Sens. Actuators, B, 362, 131829.
[80] He, C., He, Q., Deng, C., Shi, L., Fu, Y., Cao, H., and Cheng, J., 2011, Determination of methamphetamine hydrochloride by highly fluorescent polyfluorene with NH2-terminated side chains, Synth. Met., 161 (3-4), 293–297.
[81] Wen, D., Fu, Y.Y., Shi, L.Q., He, C., Dong, L., Zhu, D.F., He, Q.G., Cao, H.M., and Cheng, J.G., 2012, Fine structural tuning of fluorescent copolymer sensors for methamphetamine vapor detection, Sens. Actuators, B, 168, 283–288.
[82] Rouhani, S., and Haghgoo, S., 2015, A novel fluorescence nanosensor based on 1,8-naphthalimide-thiophene doped silica nanoparticles, and its application to the determination of methamphetamine, Sens. Actuators, B, 209, 957–965.
[83] Dennis, A.M., Rhee, W.J., Sotto, D., Dublin, S.N., and Bao, G., 2012, Quantum dot–fluorescent protein FRET probes for sensing intracellular pH, ACS Nano, 6 (4), 2917–2924.
[84] Mohammad‐Rezaei, R., and Razmi, H., 2012, Reduced graphene oxide|carbon ceramic electrode modified with CdS-hemoglobin as a sensitive hydrogen peroxide biosensor, Electroanalysis, 24 (11), 2094–2101.
[85] Roushani, M., and Shahdost-Fard, F., 2017, Ultra-sensitive detection of ibuprofen (IBP) by electrochemical aptasensor using the dendrimer-quantum dot (Den-QD) bioconjugate as an immobilization platform with special features, Mater. Sci. Eng., C, 75, 1091–1096.
[86] Masteri-Farahani, M., and Mosleh, N., 2019, Modified CdS quantum dots as selective turn-on fluorescent nanosensor for detection and determination of methamphetamine, J. Mater. Sci.: Mater. Electron., 30 (24), 21170–21176.
[87] Shen, J., Zhu, Y., Yang, X., and Li, C., 2012, Graphene quantum dots: Emergent nanolights for bioimaging, sensors, catalysis and photovoltaic devices, Chem. Commun., 48 (31), 3686–3699.
[88] Akhoundian, M., Alizadeh, T., Ganjali, M.R., and Norouzi, P., 2019, Ultra-trace detection of methamphetamine in biological samples using FFT-square wave voltammetry and nano-sized imprinted polymer/MWCNTs-modified electrode, Talanta, 200, 115–123.
[89] Masteri-Farahani, M., Mashhadi-Ramezani, S., and Mosleh, N., 2020, Molecularly imprinted polymer containing fluorescent graphene quantum dots as a new fluorescent nanosensor for detection of methamphetamine, Spectrochim. Acta, Part A, 229, 118021.
[90] Mandani, S., Rezaei, B., and Ensafi, A.A., 2020, Sensitive imprinted optical sensor based on mesoporous structure and green nanoparticles for the detection of methamphetamine in plasma and urine, Spectrochim. Acta, Part A, 231, 118077.
[91] Goulding, W., Sun, Y., and Ashley, J., 2025, NanoMIP beacons with a co-operative binding mechanism for the all-in-one detection of methamphetamine aptamer complexes, Biosens. Bioelectron., 267, 116856.
[92] Saberi, Z., Rezaei, B., Faroukhpour, H., and Ensafi, A.A., 2018, A fluorometric aptasensor for methamphetamine based on fluorescence resonance energy transfer using cobalt oxyhydroxide nanosheets and carbon dots, Microchim. Acta, 185 (6), 303.
[93] Li, B., Li, K., Xu, W., Yan, M., Zhao, J., Zhang, W., Yuan, M., Fu, Y., He, Q., and Cheng, J., 2023, Micro-interfaces modulation by UV—ozone substrate treatment for MPEA vapor fluorescence detection, Nano Res., 16 (3), 4055–4060.
[94] Liu, K., Shang, C., Wang, Z., Qi, Y., Miao, R., Liu, K., Liu, T., and Fang, Y., 2018, Non-contact identification and differentiation of illicit drugs using fluorescent films, Nat. Commun., 9 (1), 1695.
[95] Zhang, Y., Bunes, B.R., Wu, N., Ansari, A., Rajabali, S., and Zang, L., 2018, Sensing methamphetamine with chemiresistive sensors based on polythiophene-blended single-walled carbon nanotubes, Sens. Actuators, B, 255, 1814–1818.
[96] Elmizadeh, H., Bardajee, G.R., and Moaddeli, A., 2023, Ultrasensitive and rapid detection of methamphetamine in forensic biological fluids using fluorescent apta-nanobiosensors based on CdTe quantum dots, Microchem. J., 189, 108519.
[97] Ghorbanizamani, F., Moulahoum, H., and Timur, S., 2021, Noninvasive optical sensor for the detection of cocaine and methamphetamine in saliva using rhodamine B-labeled polymersomes, IEEE Sens. J., 22 (2), 1146–1153.
[98] Awata, S., Kikuchi, F., and Oba, T., 2025, Naked-eye sensor for rapid methamphetamine screening with analyte recovery, Forensic Chem., 42, 100634.
[99] Xiao, R., Wang, D., Lin, Z., Qiu, B., Liu, M., Guo, L., and Chen, G., 2015, Disassembly of gold nanoparticle dimers for colorimetric detection of ochratoxin A, Anal. Methods, 7 (3), 842–845.
[100] Petryayeva, E., and Krull, U.J., 2011, Localized surface plasmon resonance: Nanostructures, bioassays and biosensing—A review, Anal. Chim. Acta, 706 (1), 8–24.
[101] Yarbakht, M., and Nikkhah, M., 2016, Unmodified gold nanoparticles as a colorimetric probe for visual methamphetamine detection, J. Exp. Nanosci., 11 (7), 593–601.
[102] Shi, Q., Shi, Y., Pan, Y., Yue, Z., Zhang, H., and Yi, C., 2015, Colorimetric and bare eye determination of urinary methylamphetamine based on the use of aptamers and the salt-induced aggregation of unmodified gold nanoparticles, Microchim. Acta, 182 (3), 505–511.
[103] Mao, K., Yang, Z., Li, J., Zhou, X., Li, X., and Hu, J., 2017, A novel colorimetric biosensor based on non-aggregated Au@Ag core–shell nanoparticles for methamphetamine and cocaine detection, Talanta, 175, 338–346.
[104] Mao, K., Ma, J., Li, X., and Yang, Z., 2019, Rapid duplexed detection of illicit drugs in wastewater using gold nanoparticle conjugated aptamer sensors, Sci. Total. Environ., 688, 771–779.
[105] Adegoke, O., Zolotovskaya, S., Abdolvand, A., and Daeid, N.N., 2020, Biomimetic graphene oxide-cationic multi-shaped gold nanoparticle-hemin hybrid nanozyme: Tuning enhanced catalytic activity for the rapid colorimetric apta-biosensing of amphetamine-type stimulants, Talanta, 216, 120990.
[106] Bastami, T.R., Ghamari, Y., Khadempir, S., Khorasani, M.E., Paolesse, R., and Bayat, M., 2024, Discriminative detection of morphine and methamphetamine-like street samples by label-free Cu doped-silver nanoparticles chemosensor, J. Ind. Eng. Chem., 131, 459–469.
[107] Zagatto, E.A.G., Oliveira, C.C., Townshend, A., and Worsfold, P., 2012, Flow Analysis with Spectrophotometric and Luminometric Detection, Elsevier, Amsterdam, Netherlands.
[108] Wang, Z., Dong, B., Feng, G., Shan, H., Huan, Y., and Fei, Q., 2019, Water-soluble hemin-mPEG-enhanced luminol chemiluminescence for sensitive detection of hydrogen peroxide and glucose, Anal. Sci., 35 (10), 1135–1140.
[109] Zhao, S., Chen, X., Huang, J., Zhang, X., Sun, J., and Yang, L., 2022, Point-of-care testing of methylamphetamine with a portable optical fiber immunosensor, Anal. Chim. Acta, 1192, 339345.
[110] Hassanzadeh, J., Khataee, A., and Lotfi, R., 2017, Sensitive fluorescence and chemiluminescence procedures for methamphetamine detection based on CdS quantum dots, Microchem. J., 132, 371–377.
[111] Rosy, R., Yadav, S.K., Agrawal, B., Oyama, M., and Goyal, R.N., 2014, Graphene modified palladium sensor for electrochemical analysis of norepinephrine in pharmaceuticals and biological fluids, Electrochim. Acta, 125, 622–629.
[112] Roushani, M., Dizajdizi, B.Z., Salimi, A., and Azadbakht, A., 2019, Preparation of modified glassy carbon electrode by the use of titanium oxide, copper and palladium nanoparticles and its application for the electrocatalytic and photelectrocatalytic reduction of hydrogen peroxide, J. Mater. Sci.: Mater. Electron., 30 (5), 5212–5221.
[113] Razmi, H., Ezzati, L., and Khorablou, Z., 2019, Direct electrochemical synthesis of graphene oxide/cobalt oxide nanocomposite on pencil graphite electrode for highly sensitive and selective detection of insulin in pharmaceutical samples, J. Electrochem. Soc., 166 (12), B961.
[114] Karim-Nezhad, G., Khorablou, Z., and Dorraji, P.S., 2016, Modification of glassy carbon electrode with a bilayer of multiwalled carbon nanotube/poly (l-arginine) in the presence of surfactant: Application to discrimination and simultaneous electrochemical determination of dihydroxybenzene isomers, J. Electrochem. Soc., 163 (7), B358.
[115] Baghbamidi, S.E., Beitollahi, H., Tajik, S., and Hosseinzadeh, R., 2016, Voltammetric sensor based on 1-benzyl-4-ferrocenyl-1H-[1,2,3]-triazole/carbon nanotube modified glassy carbon electrode; detection of hydrochlorothiazide in the presence of propranolol, Int. J. Electrochem. Sci., 11 (12), 10874–10883.
[116] Rezaei, B., Irannejad, N., 2019, “Electrochemical detection techniques in biosensor applications” in Electrochemical Biosensors, Eds. Ensafi, A.A., Elsevier, Amsterdam, Netherlands, 11–43.
[117] Kohzadi, R., Molaeirad, A., Alijanianzadeh, M., Kamali, N., and Mohtashamifar, M., 2016, Designing a label free aptasensor for detection of methamphetamine, Biomacromol. J., 2 (1), 28–33.
[118] Švorc, Ľ., Vojs, M., Michniak, P., Marton, M., Rievaj, M., and Bustin, D., 2014, Electrochemical behavior of methamphetamine and its voltammetric determination in biological samples using self-assembled boron-doped diamond electrode, J. Electroanal. Chem., 717-718, 34–40.
[119] Oghli, A.H., Alipour, E., and Asadzadeh, M., 2015, Development of a novel voltammetric sensor for the determination of methamphetamine in biological samples on the pretreated pencil graphite electrode, RSC. Adv., 5 (13), 9674–9682.
[120] Bartlett, C.A., Taylor, S., Fernandez, C., Wanklyn, C., Burton, D., Enston, E., Raniczkowska, A., Black, M., and Murphy, L., 2016, Disposable screen printed sensor for the electrochemical detection of methamphetamine in undiluted saliva, Chem. Cent. J., 10 (1), 3.
[121] Razmi, H., Sarhang-Zadeh, K., and Mohammad-Rezaei, R., 2013, Electrochemical behavior and voltammetric determination of diclofenac at a multi-walled carbon nanotube-ionic liquid composite modified carbon ceramic electrode, Anal. Lett., 46 (12), 1885–1896.
[122] Demir, B., Yilmaz, T., Guler, E., Gumus, Z.P., Akbulut, H., Aldemir, E., Coskunol, H., Colak, D.G., Cianga, I., Yamada, S., Timur, S., Endo, T., and Yagci, Y., 2016, Polypeptide with electroactive endgroups as sensing platform for the abused drug ‘methamphetamine’ by bioelectrochemical method, Talanta, 161, 789–796.
[123] Dokuzparmak, E., Brown, K., and Dennany, L., 2021, Electrochemiluminescent screening for methamphetamine metabolites, Analyst, 146 (10), 3336–3345.
[124] Xie, Y., Wu, S., Chen, Z., Jiang, J., and Sun, J., 2022, Rapid nanomolar detection of methamphetamine in biofluids via a reagentless electrochemical aptamer-based biosensor, Anal. Chim. Acta, 1207, 339742.
[125] Ghorbanizamani, F., Moulahoum, H., Guler Celik, E., and Timur, S., 2022, Ionic liquid-hydrogel hybrid material for enhanced electron transfer and sensitivity towards electrochemical detection of methamphetamine, J. Mol. Liq., 361, 119627.
[126] Beduk, D., Beduk, T., de Oliveira Filho, J.I., Ait Lahcen, A., Aldemir, E., Guler Celik, E., Salama, K.N., and Timur, S., 2023, Smart multiplex point-of-care platform for simultaneous drug monitoring, ACS. Appl. Mater. Interfaces, 15 (31), 37247–37258.
[127] Haghighi, M., Shahlaei, M., Irandoust, M., and Hassanpour, A., 2020, New and sensitive sensor for voltammetry determination of methamphetamine in biological samples, J. Mater. Sci.: Mater. Electron., 31 (14), 10989–11000.
[128] Anvari, L., Ghoreishi, S.M., Faridbod, F., and Ganjali, M.R., 2021, Electrochemical determination of methamphetamine in human plasma on a nanoceria nanoparticle decorated reduced graphene oxide (rGO) glassy carbon electrode (GCE), Anal. Lett., 54 (15), 2509–2522.
[129] Riahifar, V., Haghnazari, N., Keshavarzi, F., and Ahmadi, E., 2021, A sensitive voltammetric sensor for methamphetamine determination based on modified glassy carbon electrode using Fe3O4@poly pyrrole core-shell and graphene oxide, Microchem. J., 170, 106748.
[130] Cetó, X., Truta, F.M., Dragan, A.M., Rodríguez-Franch, E., Tertis, M., Sánchez-Pereña, Á., Comellas-Tena, S., Cristea, C., and del Valle, M., 2025, Towards the development of a portable device based on modified-voltammetric sensors for the detection of illicit drugs and seized samples, Talanta, 282, 127055.
[131] Lee, K., Saisahas, K., Soleh, A., Kunalan, V., Chang, K.H., Limbut, W., and Abdullah, A.F.L., 2022, Forensic electrochemistry: Electrochemical analysis of trace methamphetamine residues on household surfaces, J. Electrochem. Soc., 169 (5), 056514.
[132] Liu, H., 2024, Highly selective detection of methamphetamine in urine using biosynthesized graphene oxide-gold nanoparticle composite modified electrodes, Int. J. Electrochem. Sci., 19 (11), 100851.
[133] Sun, H., Liu, J., Qiu, Y., Kong, J., and Zhang, X., 2022, High sensitive electrochemical methamphetamine detection in serum and urine via atom transfer radical polymerization signal amplification, Talanta, 238, 123026.
[134] Duan, S., Chen, H., Xu, A., He, Y., Li, M., Zhang, R., Zhang, R., and Bai, H., 2024, A simple polyarginine membrane electrochemical sensor for the determination of MDMA and MDA, Anal. Biochem., 688, 115478.
[135] Anzar, N., Suleman, S., Singh, Y., Parvez, S., Khanuja, M., Pilloton, R., and Narang, J., 2023, Wearable electrochemical glove-based analytical device (eGAD) for the detection of methamphetamine employing silver nanoparticles, Biosensors, 13 (10), 934.
[136] Anzar, N., Suleman, S., Bano, H., Parvez, S., Khanuja, M., Pilloton, R., and Narang, J., 2023, Paper-based electrodes decorated with silver and zinc oxide nanocomposite for electro-chemical sensing of methamphetamine, Sensors, 23 (12), 5519.
[137] Suleman, S., Anzar, N., Patil, S., Ansari, S., Jahan, F., and Narang, J., 2025, Development of an electrochemical paper based multiplex analytical device for the detection of “illicit drugs” employing silver nanoparticles, Mater. Chem. Phys., 338, 130649.
[138] Saisahas, K., Soleh, A., Somsiri, S., Senglan, P., Promsuwan, K., Saichanapan, J., Kanatharana, P., Thavarungkul, P., Lee, K., Chang, K.H., Abdullah, A.F.L., Tayayuth, K., and Limbut, W., 2022, Electrochemical sensor for methamphetamine detection using laser-induced porous graphene electrode, Nanomaterials, 12 (1), 73.
[139] Zhao, B., Wang, C., Huang, J., and Zhang, J., 2025, Wood-derived ionic conductive cellulose for transparent and flexible methamphetamine analog sensors, ACS Omega, 10 (17), 17770–17776.
[140] Watanabe, K., Okada, K., and Katsu, T., 1993, Determination of methamphetamine in urine in situ using a methamphetamine-sensitive membrane electrode, Anal. Chim. Acta, 274 (1), 59–63.
[141] Hayat, A., Catanante, G., and Marty, J.L., 2014, Current trends in nanomaterial-based amperometric biosensors, Sensors, 14 (12), 23439–23461.
[142] Zhang, L.Y., and Liu, Y.J., 2014, Label-free amperometric immunosensor based on prussian blue as artificial peroxidase for the detection of methamphetamine, Anal. Chim. Acta, 806, 204–209.
[143] Randviir, E.P., and Banks, C.E., 2013, Electrochemical impedance spectroscopy: An overview of bioanalytical applications, Anal. Methods, 5 (5), 1098–1115.
[144] Yeh, C.H., Wang, W.T., Shen, P.L., and Lin, Y.C., 2012, A developed competitive immunoassay based on impedance measurements for methamphetamine detection, Microfluid. Nanofluid., 13 (2), 319–329.
[145] Yang, Y., Pan, J., Hua, W., and Tu, Y., 2014, An approach for the preparation of highly sensitive electrochemical impedimetric immunosensors for the detection of illicit drugs, J. Electroanal. Chem., 726, 1–6.
[146] Ebrahimi, M., Johari-Ahar, M., Hamzeiy, H., Barar, J., Mashinchian, O., and Omidi, Y., 2012, Electrochemical impedance spectroscopic sensing of methamphetamine by a specific aptamer, BioImpacts, 2, 91.
[147] Anvari, L., Ghoreishi, S.M., Khoshnevisan, K., Ganjali, M.R., and Faridbod, F., 2023, Methamphetamine determination using label-free impedimetric aptasensor based on ceria nanocomposite, J. Appl. Electrochem., 53 (9), 1843–1851.
[148] Khorablou, Z., Shahdost-fard, F., and Razmi, H., 2022, Nanodiamond-derived carbon nano-onions decorated with silver nanodendrites as an effective sensing platform for methamphetamine detection, Surf. Interfaces, 31, 102061.
[149] Rafiee, B., Fakhari, A.R., and Ghaffarzadeh, M., 2015, Impedimetric and stripping voltammetric determination of methamphetamine at gold nanoparticles-multiwalled carbon nanotubes modified screen printed electrode, Sens. Actuators, B, 218, 271–279.
[150] Melo, L.M., de Faria, L.V., Arantes, L.C., Richter, E.M., Munoz, R.A.A., and dos Santos, W.T.P., 2024, Combined colorimetric and electrochemical screening method using 3D printed devices: Towards the selective detection of MDMA in forensic samples, Electrochim. Acta, 483, 144041.
[151] Dragan, A.M., Parrilla, M., Sleegers, N., Slosse, A., Van Durme, F., van Nuijs, A., Oprean, R., Cristea, C., and De Wael, K., 2023, Investigating the electrochemical profile of methamphetamine to enable fast on-site detection in forensic analysis, Talanta, 255, 124208.
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