New Derivatives of Thiazolidine and Their Complexes with Cu2+ and Ag+: Synthesis, Theoretical Study, and Anti-Breast Cancer Activity

https://doi.org/10.22146/ijc.111625

Hiba Mohamed Dagher(1), Rafid Humaidan Al-Asadi(2), Khawla Salman Abdalrasool(3), Mohammed Khalaf Mohammed(4*)

(1) Departments of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah 61004, Iraq; Alsafa High School, Education Directorate of Maisan, Ministry of Education, Maisan 62001, Iraq
(2) Departments of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah 61004, Iraq
(3) Departments of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah 61004, Iraq
(4) Departments of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah 61004, Iraq
(*) Corresponding Author

Abstract


Thiazolidine complexes have attracted interest due to their diverse coordination properties and biological activities. In this study, four new thiazolidine-4-carboxylic acid complexes (L1–L4) were synthesized by reacting L-cysteine with different aromatic and aliphatic aldehydes, followed by reaction with Cu(II) and Ag(I) ions in a 1:2 ratio. These complexes were extensively characterized by elemental analysis, FTIR, UV-vis, NMR, mass spectroscopy, magnetic susceptibility, molar conductivity, thermogravimetric analysis, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX). From spectroscopic analysis, it was revealed that all the complexes were bidentate NO-donor type, exhibiting square-planar or octahedral geometries around Cu(II) ion and tetrahedral geometries around Ag(I) ion. The cytotoxic activities of some complexes were evaluated against MCF-7 breast cancer cell lines. The results showed that all four ligands exhibited moderate cytotoxicity, whereas the Cu(L3)2 and Ag(L4)2 complexes showed greater cytotoxicity than their free ligands. DFT calculations were performed to confirm the study's results, which revealed that thiazolidine derivative complexes have greater potential to be developed into effective metal-based anticancer drugs.


Keywords


thiazolidine; DFT; anti-breast cancer; MTT; metal complexes



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DOI: https://doi.org/10.22146/ijc.111625

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