The Washout Test for Composite Silica-Modified Hydroxyapatite/Silica/Cerium Oxide in Ringer’s Solution

Tri Windarti; Ismiyarto Ismiyarto; Zahra Carissa Alhalim; Iis Nurhasanah; Leny Yuliatun; Limpat Nulandaya

doi:10.22146/ijc.114446

The Washout Test for Composite Silica-Modified Hydroxyapatite/Silica/Cerium Oxide in Ringer’s Solution

https://doi.org/10.22146/ijc.114446

Tri Windarti^(1*), Ismiyarto Ismiyarto⁽²⁾, Zahra Carissa Alhalim⁽³⁾, Iis Nurhasanah⁽⁴⁾, Leny Yuliatun⁽⁵⁾, Limpat Nulandaya⁽⁶⁾

(1) Department of Chemistry, Faculty of Science and Mathematics, Universitas Diponegoro, Jl. Prof. Soedharto SH, Tembalang, Semarang 50275, Indonesia
(2) Department of Chemistry, Faculty of Science and Mathematics, Universitas Diponegoro, Jl. Prof. Soedharto SH, Tembalang, Semarang 50275, Indonesia
(3) Department of Chemistry, Faculty of Science and Mathematics, Universitas Diponegoro, Jl. Prof. Soedharto SH, Tembalang, Semarang 50275, Indonesia
(4) Department of Physics, Faculty of Science and Mathematics, Universitas Diponegoro, Jl. Prof. Soedharto SH, Tembalang, Semarang 50275, Indonesia
(5) Research Center of Biomass and Bioproduct, National Research and Innovation Agency, Soekarno Science and Technology Area (KST), Jl. Raya Jakarta-Bogor Km. 46 Cibinong, Bogor 16911, Indonesia
(6) Center for Progressive Materials-Technology and Innovation Park, Pavol Jozef Šafárik University, 04111 Košice, Slovakia; Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 04001 Košice, Slovakia
(*) Corresponding Author

Abstract

A composite of silica-modified hydroxyapatite (HA-SiO₂), silica (SiO₂), and cerium oxide (CeO₂) has been developed as a calcium phosphate cement (CPC) for osteoporotic bone filler. The CPC was produced by mixing HA-SiO₂, SiO₂, and CeO₂ in a ratio of 8:1:1 (w/w) with a solution of 1% Na₂HPO₄ at a v/w ratio of 1. A washout test was conducted using Ringer’s solution for 4 days to study the interaction of water and ions with the CPC. Anti-washout properties of a CPC are very important for successful implantation. The results showed that the immersion of CPC in Ringer’s solution for 4 days did not change the chemical and crystal properties of the HA and CeO₂. Changes occurred on the CPC surface due to water intrusion and the slight dissolution of its components. However, these changes did not result in CPC washout. The released HA and CeO₂ were re-deposited onto the CPC surface, sustaining the presence of CeO₂ on the CPC surface. These results confirm the feasibility of further testing of CPC as a candidate for use as an osteoporotic bone filler.

Keywords

hydroxyapatite; silica; cerium oxide; calcium phosphate cement

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DOI: https://doi.org/10.22146/ijc.114446