Radiochemical Separation of 161Tb from Gd/Tb Matrix Using Ln Resin Column

https://doi.org/10.22146/ijc.21143

Azmairit Aziz(1*), Widya Tania Artha(2)

(1) Center for Nuclear Applied Science and Technology, National Nuclear Energy Agency, Jl. Tamansari 71 Bandung 40132
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology - ITB, Jl. Ganesha 10, Bandung 40132
(*) Corresponding Author

Abstract


Terbium-161 (161Tb) is a potential radiolanthanide due to its favorable properties for treatment small size of cancer. Preliminary study on radiochemical separation of 161Tb from Gd/Tb matrix using Ln resin column based on extraction chromatography method has been carried out. 161Tb radionuclide was produced by irradiation of natural Gd2O3 target through neutron thermal bombardment at G.A. Siwabessy Multipurpose Reactor. Fractions eluted from the column containing Gd/Tb matrix of irradiated natural Gd2O3 target were identified and quantified using a γ-rays spectrometer with HP-Ge detector coupled to a multichannel analyzer. The results show that the optimum condition on 161Tb separation from irradiated Gd2O3 target with radionuclide purity 99.27 ± 0.30% was obtained using HNO3 solution with concentration of 0.8 and 3 N to separate gadolinium and terbium isotope, respectively. The yield of 161Tb obtained from the separation was 61.21 ± 2.05% and Gd recovered was 97.15 ± 2.23%. Based on this experiment, 161Tb has been separated from irradiated natural gadolinium oxide target with high radionuclide purity.

Keywords


radiolanthanide; terbium-161; carrier free; therapy; cancer

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References

[1] Zhang, L., Chen, H., Wang, L., Liu, T., Yeh, J., Lu, G., Yang, L., and Mao, H., 2010, Nanotechnol. Sci. Appl., 3, 159–170.

[2] Luo, T.Y., Tang, I.C., Wu, Y.L., Hsu, K.L., Liu, S.W., Kung, H.C., Lai, P.S., and Lin, W.J., 2009, Nucl. Med. Biol., 36 (1), 81–88.

[3] YKI-Jakarta Race, 2012, Indonesian Cancer Foundation, http://yayasankankerindonesia.org/ 2012/yki-jakarta-race/, accessed on July 5, 2014.

[4] Ersahin, D., Doddamane, I., and Cheng, D., 2011, Cancers, 3 (4), 3838–3855.

[5] Sadeghi, M., Enferadi, M., and Shirazi, A., 2010, J. Cancer Res. Ther., 6 (3), 239–248.

[6] Sisay, N., 2014, Selection of Small Pretargeting Peptide with Affinity for Radiochelates and Separation and Purification of Radiolanthanides, Dissertation, University of Missouri, USA, 1–122.

[7] Lehenberger, S., Barkhausen, C., Cohrs, S., Fischer, E., Grünberg, J., Hohn, A., Köster, U., Schibli, R., Türler, A., and Zhernosekov, K., 2011, Nucl. Med. Biol., 38 (6), 917–924.

[8] Cutler, C.S., Hennkens, H.M., Sisay, N., Huclier-Markai, S., and Jurisson, S.S., 2013, Chem. Rev., 113 (2), 858–883.

[9] Lehenberger, S.M., 2010, Evaluation and Application of The Low Energy Electron Emitter 161Tb, Dissertation, Technische Universitat Munchen, Germany, 1–140.

[10] Rösch, F., 2007, Radiochim. Acta., 95 (6), 303–311.

[11] Rösch, F., Seventh International Conference on Nuclear and Radiochemistry, Hungary, 24-29 August 2008.

[12] Uusijärvi, H., Bernhardt, P., Rösch, F., Maecke, H.R., and Forssell-Aronsson, E., 2006, J. Nucl. Med., 47, 807–814.

[13] Grünberg, J., Lindenblatt, D., Dorrer, H., Cohrs, S., Zhernosckov, K., Köster, U., Türler, A., Fischer, E., and Schibli, R., 2014, Eur. J. Nucl. Med. Mol. Imaging, 41 (10), 1907–1915.

[14] Müller, C., Zhernosekov, K., Köster, U., Johnston, K., Dorrer, H., Hohn, A., van der Walt, N.T., Türler, A., and Schibli, R., 2012, J. Nucl. Med., 53, 1951–1959.

[15] Müller, C., Reber, J., Haller, S., Dorrer, H., Bernhardt, P., Zhernosekov, K., Türler, A., and Schibli, R., 2014, Eur. J. Nucl. Med. Mol. Imaging, 41 (3), 476–485.

[16] Weast, R.C., 1987, Handbook of Chemistry and Physics, ed. Astle, M.J., and Beyer, W.H., 68th ed., CRC Press, Inc., Florida, USA, B-335.

[17] Guzman, F.M., Morales, J.A., 2010, Radioisotope Production for Health Applications, Eds. Mojica, G.D., Reyes, M.J., Guzman, F.M., Hernandez, S.R., and Guerrero, J.S., ININ, Mexico, 67–87.

[18] Ketring, A.R., Ehrhardt, G.J., Embree, M.F., Bailey, K.D., Tyler, T.T., Gawenis, J.A., Jurisson, S.S., Engelbrecht, H.P., Smith, C.J., and Cutler, C.S., 2003, Alasbimn J., 5 (19), 1–6.

[19] Aziz, A., Preliminary Study on Separation of Terbium-161 (161Tb) Radioisotope from Gd/Tb Matrix Using Ion Exchange Resin, Proceeding of National Conference on Nuclear Science and Technology, Bandung, 3 December 2015, 191–198.



DOI: https://doi.org/10.22146/ijc.21143

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