Synthesis Methyl Nitrophenyl Acrylate and Cytotoxic Activity Test against P388 Leukemia Cells

Teni Ernawati; Zulfa Khoirunni’mah

doi:10.22146/ijc.21226

Synthesis Methyl Nitrophenyl Acrylate and Cytotoxic Activity Test against P388 Leukemia Cells

https://doi.org/10.22146/ijc.21226

Teni Ernawati^(1*), Zulfa Khoirunni’mah⁽²⁾

(1) Research Center for Chemistry - Indonesian Institute of Sciences (LIPI), Kawasan Puspiptek Serpong, Tangerang Selatan 15314
(2) Program Study Pharmacy-Faculty of Medicine and Health Sciences, Syarif Hidayatullah State Islamic University (UIN) Jakarta
(*) Corresponding Author

Abstract

Synthesis of methyl nitrophenyl acrylate via modification of methyl trans-cinnamate had been done to improve its biological activity. The reaction of methyl trans-cinnamate with nitrating agent gave methyl 3-(2-nitrophenyl)acrylate and methyl 3-(4-nitrophenyl)acrylate with an ortho/para ratio of 1:8. Its structure was confirmed with ¹H-NMR, ¹³C-NMR, FTIR, GC-MS. Biological activity of methyl 3-(4-nitrophenyl)acrylate and methyl 3-(2-nitrophenyl)acrylate assays was performed on Cancer cells against P388 Murine Leukemia with IC₅₀= 7.98 μg/mL, IC₅₀ = 27.78 μg/mL.

Keywords

nitration; methyl trans-cinnamate; methyl 3-(2-nitrophenyl)acrylate; 3-(4-nitrophenyl)acrylate; P388 leukemia cells

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DOI: https://doi.org/10.22146/ijc.21226