Di-(2-ethylhexyl)phthalate and Pyranon Derivated from Endophytic fungi Penicillium sp the Leave of Kunyit Putih (Curcuma zedoaria)

https://doi.org/10.22146/ijc.21241

Muharni Muharni(1*), Fitrya Fitrya(2), Milanti Okta Ruliza(3), Dwi Anjar Susanti(4), Elfita Elfita(5)

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences , Sriwijaya University, Jl. Raya Palembang Prabumulih Km 32, Indralaya, Ogan Ilir, South Sumatera 30662
(2) Department of Pharmacy, Faculty of Mathematics and Natural Sciences , Sriwijaya University, Jl. Raya Palembang Prabumulih Km 32, Indralaya, Ogan Ilir, South Sumatera 30662
(3) Department of Chemistry, Faculty of Mathematics and Natural Sciences , Sriwijaya University, Jl. Raya Palembang Prabumulih Km 32, Indralaya, Ogan Ilir, South Sumatera 30662
(4) Department of Chemistry, Faculty of Mathematics and Natural Sciences , Sriwijaya University, Jl. Raya Palembang Prabumulih Km 32, Indralaya, Ogan Ilir, South Sumatera 30662
(5) Department of Chemistry, Faculty of Mathematics and Natural Sciences , Sriwijaya University, Jl. Raya Palembang Prabumulih Km 32, Indralaya, Ogan Ilir, South Sumatera 30662
(*) Corresponding Author

Abstract


Two compounds from cultivation of the endophytic fungi Penicillium sp of leaves of kunyit putih (Curcuma zedoaria have been isolated. The endophytic fungus was cultivated on 5 L of Potatos Dextrose Broth (PDB) medium at room temperature (no shaking) for 3 weeks. The cultures were extracted with ethyl acetate to afford 3.0 g of residue after removal of the solvent under reduced pressure. The extract was separated and purified by silica gel column chromatography (CC) and afforded two pure compounds as colorless oily liquid (compound 1) and yellow crystal (compound 2). The structure of these compounds were characterized by detailed UV, IR, and NMR spectroscopic analysis and compound 1 as well as comparison with the reported data. Base on spectra analysis the compound 1 was determined as Di-(2-ethylhexyl)phthalate and compound 2 as 5-(4’-ethoxy-2’-hydroxy-5’-methyl-2’,3’-dihydrofuran-3’-il (hydroxy) methyl-4-isopropyl-3-methyl-2-pyran-2-on). Compound 1 is not new compound, but it is new for endophytic fungus from C. zeodoria and compound 2 is new compound.

Keywords


endophytic fungi; Penicillium sp; Curcuma zedoaria

Full Text:

Full Text Pdf


References

[1] Strobel, G., Daisy, B., and Castillo, U., 2005, Plant Pathol. J., 4 (2), 161–176.

[2] Premjanu, N., and Jayanthy, C., 2012, Int. J. Inst. Pharm. Life Sci., 2 (1), 135–162.

[3] Lakshmi, S., Padmaja, G., and Remani, P., 2011, Int. J. Med. Chem., 2011, 1–13.

[4] Saikia, N., and Nath, S.C., 2003, J. Econ. Taxon. Bot., 27, 430–433.

[5] Jang, M.K., Sohn, D.H., and Ryu, J-H., 2001, Planta Med., 67 (6), 550–552.

[6] Wilson, B., Abraham, G., Manju, V.S., Mathew, M., Vimala, B., Sundaresan, S., and Nambisan, B., 2005, J. Ethnopharmacol., 99 (1), 147–151.

[7] Bugno, A., Nicoletti, M.A., Almodóvar, A.A.B., Pereira, T.C., and Auricchio, M.T., 2007, Braz. J. Microbiol., 28, 440–445.

[8] Elfita, Muharni, Munawar, Legasari, L., and Darwati, 2011, Indo. J. Chem., 11 (1), 53–58.

[9] Elfita, Muharni, Munawar, and Aryani, S., 2012, Indo. J. Chem., 12 (2), 195–200.

[10] Xu, L., Zhou, J., Zhao, J., Li, X., and Wang, J., 2008, Lett. Appl. Microbiol., 46 (1), 68–72.

[11] dos Santos, R.M.G., and Rodrigues-Fo, E., 2003, Z. Naturforsch., 58c, 663–669.

[12] Yan, H-J., Gao, S-S., Li, C-S., Li, X-M., and Wang, B-G., 2010, Molecules, 15 (5), 3270–3275.

[13] Barik, B.P., Tayung, K., Jagadev, P.N., and Dutta, S.K., 2010, Eur. J. Biol. Sci., 2 (1), 8–16.

[14] Guo, L., Wu, J-Z., Han, T., Cao, T., Rahman, K., and Qin, L-P., 2008, Molecules, 13 (9), 2114–2125.

[15] Habib, M.R., and Karim, M.R., 2009, Micobiology, 37 (1), 31–36.

[16] Mavar-Manga, H., Haddad, M., Pieters, L., Baccelli, C., Penge, A., and Quetin-Leclercq, J., 2008, J. Ethnopharmacol., 115 (1), 25–29.

[17] Lee, K.H., Kim, J.H., Lim, D.S., and Kim, C.H., 2000, J. Pharm. Pharmacol., 52 (5), 593–598.



DOI: https://doi.org/10.22146/ijc.21241

Article Metrics

Abstract views : 2143 | views : 2783


Copyright (c) 2014 Indonesian Journal of Chemistry

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 

Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

Web Analytics View The Statistics of Indones. J. Chem.