Computer Aided Design of Molecular Imprinted Polymer for Selective Recognition of Capsaicin

https://doi.org/10.22146/ijc.21272

Iqmal Tahir(1*), Karna Wijaya(2), Shafiqul Islam(3), Mohd Noor Ahmad(4)

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta 55281
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta 55281
(3) School of Material Engineering, University Malaysia Perlis, Jejawi Arau 02600
(4) School of Bioprocess Engineering, University of Malaysia, Perlis, Jejawi Arau 02600
(*) Corresponding Author

Abstract


Searching capsaicin-like molecule as an alternative dummy template has been conducted for the synthesis of Molecularly Imprinted Polymer (MIP) of capsaicin. Dummy template should be applied because synthesis of capsaicin practically has a problem due to its structure containing double bond at the aliphatic chains. Virtual searching was done using an online chemical database of ChemDB containing 5 million commercial molecules. Capsaicin structure was converted into SMILES code and then it was run on ChemDB with molecular similarity threshold of 0.5. There were 69 chemical structures obtained as the output and pseudocapsaicin was practically selected as the dummy template. Experimental result from the prediction evaluation showed that the use of capsaicin as template and pseudocapsaicin as dummy template produced MIPs that have separation factor of 1.28 and 1.25 respectively. It is suggested to choose pseudocapsaicin as dummy template for the synthesis MIP of capsaicin instead of using capsaicin molecule.

Keywords


capsaicin; molecular imprinted polymer; chemical database; molecular similarity; dummy template

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References

[1] Reyes-Escogido, M.L., Gonzalez-Mondragon, E.G., and Vazquez-Tzompantzi, E., 2011, Molecules, 16 (2), 1253–1270.

[2] Kaale, E., van Schepdael, A., Roets, E., and Hoogmartens, J., 2002, J. Pharm. Biomed. Anal., 30 (4), 1331–1337.

[3] Cisneros-Pineda, O., Torres-Tapia, L.W., Gutiérrez-Pacheco, L.C., Contreras-Martín, F., González-Estrada, T., and Peraza-Sánchez, S.R., 2007, Food Chem., 104 (4), 1755–1760.

[4] Barbero, G.F., Liazid, A., Palma, M., and Barroso, C.G., 2008, Food Chem., 107 (3), 1276–1282.

[5] Laskaridou-Monnerville, A., 1999, J. Chromatogr. A, 838 (1-2), 293–302.

[6] Reilly, C.A., Crouch, D.J., Yost, G.S., and Fatah, A.A., 2001, J. Chromatogr. A, 912 (2), 259–267.

[7] Liu, L., Chen, X., Liu, J., Deng, X., Duan, W., and Tan, S., 2010, Food Chem., 119 (3), 1228–1232.

[8] Ersöz, A., Denizli, A., Özcan, A., and Say, R., 2005, Biosens. Bioelectron., 20 (11), 2197–2202.

[9] Ersöz, A., Diltemiz, S.E., Özcan, A.A., Denizli, A., and Say, R., 2008, Biosens. Bioelectron., 24 (4), 742–747.

[10] Sener, G., Ozgur, E., Yılmaz, E., Uzun, L., Say, R., and Denizli, A., 2010, Biosens. Bioelectron., 26 (2), 815–821.

[11] O’Sullivan, C.K., and Guilbault, G.G., 1999, Biosens. Bioelectron., 14 (8-9), 663–670.

[12] Sellergren, B., (Ed.), 2001, “Molecularly Imprinted Polymers. Man-Made Mimics of Antibodies and their Application” in Analytical Chemistry, Elsevier, Amsterdam.

[13] Sun, J., Peng, N., Ao, W., and Huang, X., 2012, Adv. Mater. Res., 430-432, 582–585.

[14] Wang, J.C., Guo, B., Chen, P., Zhang, Q., and Liang, X., 2005, Anal. Chim. Acta, 540 (2), 307–315.

[15] Wang, X.J., Xu, Z.L., Feng, J.L., Bing, N.C., and Yang, Z.G., 2008, J. Membr. Sci., 313 (1-2), 97–105.

[16] Feás, X., Seijas, J.A., Vázquez-Tato, M.P., Regal, P., Cepeda, A., and Fente, C., 2009, Anal. Chim. Acta, 631 (2), 237–244.

[17] Zhang, H., Song, T., Zhang, W., Hua, W., and Pan, C., 2007, Bioorg. Med. Chem., 15 (18), 6089–6095.

[18] Yin, J.F., Meng, Z.H., Du, M.J., Liu, C., Song, M.Y., and Wang, H.L., 2010, J. Chromatogr. A, 1217 (33), 5420–5426.

[19] Kubinyi, H., 1997, Drug Discovery Today, 2 (12), 538–546.

[20] Huang, H.J., Yu, H.W., Chen, C.Y., Hsu, C.H., Chen, H.Y., Lee, K.J., Tsai, F.J., and Chen, C.Y., 2010, J. Taiwan Inst. Chem. Eng., 41 (6), 623–635.

[21] Gallegos, A., Carbó-Dorca, R., Ponec, R., and Waisser, K., 2004, Int. J. Pharm., 269, 51–60.

[22] Jeong, J.A., Cho, H., Jung, S.Y., Kang, H.B., Park, J.Y., Kim, J.A., Choo, D.J., and Lee, J.Y., 2010, Bioorg. Med. Chem. Lett., 20 (1), 38–41.

[23] Chang, T., Sun, M., Wong, Y., Yang, S., Chen, K., Chen, H., Tsai, F., and Chen, C.Y., 2011, J. Taiwan Inst. Chem. Eng., 2, 580–591.

[24] Edgar, S.J., Holliday, J.D., and Willett, P., 2000, J. Mol. Graphics Modell., 18 (4), 343–357.

[25] Saliner, A.G., and Gironés, X., 2005, J. Mol. Struct. THEOCHEM, 727 (1-3), 97–106.

[26] Good, A.C., 2007, J. Mol. Graphics Modell., 26 (3), 656–666.

[27] Fukunishi, Y., and Nakamura, H., 2009, J. Mol. Graphics Modell., 27 (5), 628–636.

[28] Chen, J.H., Linstead, E., Swamidass, J., Wang, D., and Baldi, P., 2007, Bioinformatics, 23 (17), 2348–2351.

[29] Tahir, I., Ahmad, M.N., Islam, A.K.M.S., and Arbain, D., 2012, Indo. J. Chem., 12 (3), 217–222.

[30] Tan, Y., Zhou, Z., Wang, P., Nie, L., and Yao, S., 2001, Talanta, 55 (2), 337–347.

[31] Nantasenamat, C., Li, H., Isarankura-Na-Ayudhya, C., and Prachayasittikul, V., 2012, Chemom. Intell. Lab. Syst., 116, 128–136.

[32] Tantishaiyakul, V., 2005, J. Pharm. Biomed. Anal., 37 (2), 411–415.



DOI: https://doi.org/10.22146/ijc.21272

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