FLAVANONES FROM THE WOOD OF Morus nigra WITH CYTOTOXIC ACTIVITY

https://doi.org/10.22146/ijc.21277

Ferlinahayati Ferlinahayati(1*), Yana Maolana Syah(2), Lia Dewi Juliawaty(3), Euis Holisotan Hakim(4)

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Sriwijaya, Jl. Raya Palembang Prabumulih Km 32, Ogan Ilir, South Sumatera 30622
(2) Natural Product Research Group, Department of Chemistry, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung 40132
(3) Natural Product Research Group, Department of Chemistry, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung 40132
(4) Natural Product Research Group, Department of Chemistry, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung 40132
(*) Corresponding Author

Abstract


Two flavanone derivatives, norartocarpanone (1) and euchrenone a7 (2) had been isolated for the first time from the methanol extract of the wood of Morus nigra. The structures of these compounds were determined base on spectral evidence, including UV, IR, and NMR. The first compound also confirmed by comparison with the reported data. Cytotoxic properties of these compounds were evaluated against murine leukemia P-388 cells. Euchrenone a7 (2) was found more cytotoxic than norartocarpanone (1) with their IC50 7.8 and 12.7 mg/mL respectively.

Keywords


norartocarpanone; euchrenone a7; Morus nigra; cytotoxic

Full Text:

Full Text PDF


References

[1] Sun, S.G., Chen, R.Y., and Yu, D.Q., 2001, J. Asian Nat. Prod., 3, 4, 253–259.

[2] Nomura, T., 1988, Prog. Chem. Org. Nat. Prod., 53, 87–201.

[3] Nomura, T., and Hano, Y., 1994, Nat. Prod. Rep., 11, 205–218.

[4] Du, J., He, Z-D., Jiang, R-W., Ye, W-C., Xu, H-X., and But, P.P-H., 2003, Phytochemistry, 62, 8, 1235–1238.

[5] Dai, S-J., Ma, Z-B., Wu, Y., Chen, R-Y., and Yu, D-Q., 2004, Phytochemistry, 65, 23, 3135–3141.

[6] Sohn, H.-Y., Son, K.H., Kwon, C.-S., Kwon, G.-S., and Kang, S.S., 2004, Phytomedicine, 11, 7-8, 666–672.

[7] Ferrari, F., Monacelli, B., and Messana, I., 1999, Planta Med., 65, 1, 85–87.

[8] Ferlinahayati, Juliawaty, L.D., Syah, Y.M., Hakim, E.H., and Latip, J., 2011, Bull. Soc. Nat. Prod. Chem., 11, 1, 14–18.

[9] Ferlinahayati, Hakim, E.H., Syah, Y.M., and Juliawaty, L.D., 2012, Jurnal Penelitian Sains, 15, 2, 70–73.

[10] Ferlinahayati, Syah, Y.M., Juliawaty, L.D., Achmad, S.A., Hakim, E.H., Takayama, H., Said, I.M., and Latip, J., 2008, Z. Naturforsch., 63c, 35–39.

[11] Musthapa, I., 2009, Disertation, Institut Teknologi Bandung, Bandung.

[12] Mizuno, M., Tanaka, T., Matsuura, N., Iinuma, M., and Cheih, C., 1990, Phytochemistry, 29, 8, 2738–2740.

[13] Ferrari, F., Delle, M.F., Suarez, A.I., and Compagnone, R.S., 1998, Fitoterapia, 69, 6, 554–555.

[14] Akihisa, T., Tokuda, H., Hasegawa, D., Ukiya, M., Kimura, Y., Enjo, F., Suzuki, T., and Nishino, H., 2006, J. Nat. Prod., 69, 1, 38–42.



DOI: https://doi.org/10.22146/ijc.21277

Article Metrics

Abstract views : 1862 | views : 1832


Copyright (c) 2013 Indonesian Journal of Chemistry

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 

Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

Web Analytics View The Statistics of Indones. J. Chem.