RAPID SOLVENT-FREE MICROWAVE ASSISTED SYNTHESIS OF SOME N’-BENZYLIDENE SALICYLIC ACID HYDRAZIDES

https://doi.org/10.22146/ijc.21357

Tutuk Budiati(1*), Stephanie D.A.(2), Elisabeth Catherina Widjajakusuma(3)

(1) Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Jl. Dharmawangsa Dalam Selatan, Surabaya 60286
(2) Faculty of Pharmacy, Widya Mandala Catholic University, Jl. Dinoyo 42-44 Surabaya 60265
(3) Faculty of Pharmacy, Widya Mandala Catholic University, Jl. Dinoyo 42-44 Surabaya 60265
(*) Corresponding Author

Abstract


Condensation reaction has been carried out for the synthesis of some N'-benzylidene-2-hydroxybenzohydrazides using microwave assisted solvent-free method. The structures of all the products obtained in the present work are supported by spectral and analytical data (UV, IR, and 1H-NMR spectroscopy). The desired hydrazides are in 62-80% yields under microwave irradiation. The reaction was completed in 8-10 min.

Keywords


N’-benzylidene-2-hydroxybenzohydrazides; solvent-free; microwave irradiation

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DOI: https://doi.org/10.22146/ijc.21357

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