Dasril Basir(1*), Julinar Julinar(2)

(1) Department of Chemistry, Faculty of Science, University of Sriwijaya, Palembang 30662, South Sumatra
(2) Department of Chemistry, Faculty of Science, University of Sriwijaya, Palembang 30662, South Sumatra
(*) Corresponding Author


This paper describes 3-hydroxyurs-12-en-28-oic acid and its structural isomer 3-hydroxyolean-12-en-28-oic acid isolated from Fragraea fragrans fruits and their biological activities; anti-tumor, anti-inflammation, anti-microbial, and anti-fungal included their ultra violet photo-protective effect after exposed under sunlight radiation. They are useful for cosmetic ingredient. The above triterpenes are very promoting compounds for leukemia L1210 anti-tumor due to limited reports dealing with this type triterpenoid anti-tumor test. They significantly gave IC50 value of 5.78 µg/mL against leukemia L1210 cells, relatively closed to IC50 value of drugs, 4.0 µg/mL [12-13,17].


Isomeric; ursolic acid; oleanolic acid; Fragraea fragrans; cosmetic

Full Text:

Full Text PDF


[1] Abad, M.J., Ansuategui, M., and Bermejo, P., 2007, Active antifungal substances from natural sources, ARKIVOC, vii, 116–145.

[2] Baricevic, D., Sosa, S., and Simonovska, B., 2001, J. Ethnopharmacol., 75, 2-3, 125–132.

[3] Cao, B.J., Meng, Q.Y., and Ji, N., 1992, Planta Med., 58, 496-498.

[4] David, J.P., Meira, M., David, J.M., and Guedes, M.L.S., 2004, Quim. Nova, 27, 1, 62–65.

[5] Gohari, A.R., Saeidnia, S., Shahverdi, A.R., Yassa, N., Malmir, M., Mollazade, K., and Naghinejad, A.R., 2009, EurAsia J. BioSci., 3, 64–68.

[6] Patočka, J., 2003, J. Appl. Biomed., 1, 7–12.

[7] Liu, J., 1995, J. Ethnopharmacol., 49. 57–68.

[8] Maier, H., Schauberger, G., Martincigh, B.S., Brunnhofer, K., and H. Honingsmann, 2005, Photodermatol. Photoimmunol. Photomed., 21, 2, 84–92.

[9] Majeed, M., and Nujoma, Y (Copyright 2000), Ursolic acid; its importance in skin and hair beautification and protection,

[10] Martawijaya, A., 1989, Atlas kayu Indonesia, vol. II, Departemen Kehutanan Badan Penelitian dan Pengembangan Kehutanan, Bogor.

[11] Meng, Y., Song, Y., Yan, Z., and Xia, Y., 2010, Molecules, 15, 4033–4040.

[12] Nagumo A., Takanashi, K., Hojo, H., and Suzuki, Y., 1991, Toxicol Lett., 58, 3, 309–313.

[13] Novotny L., Vachalkova, A., and Biggs, D., 2001, Neoplasma, 48, 4, 241–246.

[14] Pillai, S., Oresajo, C., and Hayward, J., 2005, Int. J. Cosmet. Sci., 27, 1, 17–34.

[15] Rasyid, A., and Adachi, K., 2007, Indo. J. Chem., 7, 3, 350–353.

[16] Saleh, M., Kamel, A., Li, X., and Swaray, J., 1999, Pharm. Biol., 37, 1, 63–66.

[17] Sumatra, M., 1998, Bioassay in Vitro with L1210 Leukemia Cells, A screening method of anticancer constituents from natural products, Proceeding of Indonesian marine biotechnology seminar, Jakarta, 14-15 October, 183-188.


Article Metrics

Abstract views : 1518 | views : 1813

Copyright (c) 2012 Indonesian Journal of Chemistry

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.


Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

Analytics View The Statistics of Indones. J. Chem.