SYDNONE DERIVATIVES A SYNTHONS FOR NOVEL MESOIONIC COMPOUNDS. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME 2-(4`-SUBSTITUTED ANILINOSYNDON-3`-YL)-1, 3, 4-THIADIAZINO (6, 5-B) INDOLES

https://doi.org/10.22146/ijc.21380

Hemant Panwar(1*), Shishupal Singh(2), Nidhi Chaudhary(3)

(1) Depatment of Chemistry, Neelkanth Institute of Technology, Modipuram-250110, Meerut, U.P.
(2) Department of Chemistry, Aligarh Muslim University, Aligarh-202002, U.P.
(3) Department of Chemistry, I.I.M.T., I.E.T., Ganga Nagar, Meerut-250001, U.P.
(*) Corresponding Author

Abstract


In the present study, a series of 2-(4´-Substitutedanilinosydnon-3´-yl)-1, 3, 4-thiadiazino (6, 5-b) indoles 7a-j have been synthesized. All the synthesized compounds have been characterized by elemental and spectral (I R, 1H- NMR and Mass) spectrometric analysis. Furthermore, above mentioned compounds were evaluated for their antibacterial and antifungal activities against selected panel of pathogenic strains. Ampicillin trihydrate, ofloxacin and fluconazole, griseofulvin were used as standard drugs for antibacterial and anifungal activity respectively. Compound 7j was found the most potent one with lesser toxicity in the prepared indole derivatives.

Keywords


Indoles; Antifungal; Antibacterial; Acute toxicity

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References

[1]   Kamble, R.R., and Sudha, B.S., 2006, Indian J. Pharm. Sci., 68, 2, 249–253.

[2]   Butkovic, K., Marinic, Z., and Sindler-Kulyl, M., 2011, Arkivoc, 10, 1–15.

[3]   Kier, B.L., Dhawan, D., and Fregly, J.M., 1964, J. Pharm. Sci., 53, 677–678.

[4]   Jogul, J.J., and Badami, B.V., 2006, J. Serb. Chem. Soc., 71, 8-9, 851–860.

[5]   Shahrukh, T.A., Nikul, S.P., and Keshav, C.P., 2010, Org. Commun., 3, 2, 30–38.

[6]   Kier, L.B., Al-Shamma, A., Campbell, D, Patil, P.N., and Tye, A., 1966, Nature, 210, 742.

[7]   Satyanarayana, K., Deshpande, R.S., and Subbarao, B., 2004, Indian J. Pharm. Sci., 66, 5, 679–683.

[8]   Satyanarayana, K, and Rao, M.N.A., 1995, Ind. J. Pharm. Sci., 57, 6, 243–248.

[9]   Rani, P., Srivastava, V.K., and Kumar, A., 2004, Eur. J. Med. Chem., 39, 5, 449–452.

[10] Andreani, A., Rambaldi, M., Locatelli, A., Conti, M., and Malandrino, S., 1991, Acta Pharm. Nord., 3, 1, 5–8.

[11] Chavan, R.S., More, H.N., and Bhosale, A.V., 2010, Int. J. Pharm. Biomed. Res., 1, 4, 135–143.

[12] Bansal, E., Srivastava, K.V., and Kumar, A., 2000, Indian J. Chem., 39B, 357–362.

[13] Amir, M., Dhar, N., and Tiwari, K.S., 1997, Indian J. Chem., 36B, 96–98.

[14] Stanton, J.L., and Ackerman, M.H., 1983, J. Med. Chem., 26, 7, 986–999.

[15] Zahran, H.A.M. and Ibrahim, M.A., 2009, J. Chem. Sci., 121, 4, 455–462.

[16] Sharma, P., Kumar, A., and Pandey, P., 2006, Indian J. Chem., 45B, 2077–2082.

[17] Biradar, J.S., and Manjunath, S.Y., 2004, Indian J. Chem., 43B, 389–392.

[18] Pardasani, R.T., Pardasani, P., Sherry, D., and Chaturvedi, V., 2001, Indian J. Chem., 40B, 1275–1278.

[19] Ryu, C.K., Lee, J.Y., Park, R.E., Ma, M.Y., and Nho, J.H., 2007, Bioorg. Med. Chem. Lett., 17, 1, 127–131.

[20] Cruickshank, R., Duguid, P.J., Marion, P.B., and Swain, H.R., 1975, in Medicinal Microbiology, 12th ed., Churchill Livingstone, London, U.K.

[21] Collins, H.A., 1976, Microbiological Methods, 2nd ed., Butterworth, London, U.K.

[22] Khan, K.Z., 1997, In vitro and vivo screening techniques for bioactivity screening and evaluation, in Proceedings of the International Workshop on UNIDO-CDRI.

[23] Varma, S.R., 1998, Antifungal Agents: Past, Present and Future Prospects, National Academy of Chemistry and Biology, Lucknow, India.

[24] Panwar, H., Verma, S.R., and Srivastava, K.V., 2006, Indian J. Chem., 45B, 2099–2104.

[25] Smith, Q.E., 1960, Pharmacological screening tests progressive, in Medicinal Chemistry, vol. I, Butterworths, London.



DOI: https://doi.org/10.22146/ijc.21380

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