SYNTHESIS OF POLYETHYLENE OXIDE (PEO)–CHITOSAN HYDROGEL PREPARED BY GAMMA RADIATION TECHNIQUE

https://doi.org/10.22146/ijc.21413

Erizal Erizal(1*), Thamrin Wikanta(2)

(1) Centre for the Applications Isotope and Radiation Technology, National Nuclear Agency, Jl. Lebak Bulus Raya no.49, Jakarta 12440
(2) Centre Research for Product Processing and Biotechnology Marine & Fisheries, Jl. K.S. Tubun VI, Jakarta 10260
(*) Corresponding Author

Abstract


Crosslinked PEO hydrogel containing chitosan for wound dressing has been prepared by gamma radiation technique. Chitosan solutions with different concentration (0.5-2% w/v) have been blended with 5% aqueous solution of PEO and irradiated at the doses 20-40 kGy by gamma rays. The copolymers were characterized by Fourier transform infra red spectroscopy and their physico-chemical properties of hydrogels were evaluated in terms of gel fraction, swelling ratio, elongation at break and antimicrobial activities. It was found that under maximum condition of incorporation 1% chitosan with irradiation dose of 20 kGy, PEO-chitosan hydrogels with high gel fraction (85%), swelling ratio (10 g/g) and elongation at break (145%) were obtained. The examination of the microbe penetration shows that the prepared hydrogels can be considered as a good barrier against microbes. Thus, PEO-chitosan hydrogel showed satisfactory properties for use as a wound dressing.

Keywords


Gamma radiation; polyethylene oxide; chitosan; hydrogel; wound dressing

Full Text:

Full Text PDF


References

[1] Risbud, M., Hardikar, A., and Bhonde, R., 2000, J. BioSci., 25, 1, 25–31.

[2] Park, J.E., and Barbul, A., 2004, Am. J. Surg., 187, 511–516.

[3] Davydova, G.A., Selezneva, I.I., Savinttseva, and Gavrilyuk, B., 2008, Bull. Exp. Biol. Med., 145, 52–58.

[4] Teshima, H., Kawano, H., Kashikie, H., Nakamura, K., Imada, T., Oda, T., and Aoyogi, S., 2009, Surgery Today, 39, 1, 848–854.

[5] Korycky, R., 2009, Struct. Multidiscip. Optim., 39, 3, 283–296.

[6] Li, S-T., Cao, B., Deng, W-L., and Li, Z., 2009, Chin. J. Integr. Med., 15, 4, 279–283.

[7] Chandroth, K.S., and Tholath, E.A., 2010, Colloid Polym. Sci., 288, 3, 297–306.

[8] Erizal, 2008, Indo. J. Chem., 8, 2, 271–278.

[9] Thomas, S., 1996, Wounds, 8, 5, 145–149.

[10] Pai, K., Banthia, A.K., and Mayumdar, D.K., 2006, J. Biol. Res., 9, 23–29.

[11] Krasner, D., and Kane, D., 1997, Chronic Wound Care: A Clinical Sourcebook for Healthcare Professionals, Health Management Publications, 2nd ed., 336–343.

[12] Sorens, D.A, and Malik, S., 2005, USA Patent 6967261.

[13] Michael, P.T., and Stephen, E.H., 1997, An Introduction to Polysaccharide Biotechnology, Taylor & France, 147–149.

[14] Maolin, Z., Hongfei, H., Yoshii, F., and Makuuchi, K., 2000, Radiat. Phys. Chem., 57, 3-6, 459–464.

[15] Rosiak, J.M., Ulanski, P., Pajewski, A., Yoshii, F., and Makuuchi, K., 1995, Radiat. Phys. Chem., 46, 2, 161–168.

[16] Jing, R., Yancun, Z., Jiuqiang, L., and Hongfei, H., 2001, Radiat. Phys. Chem., 62, 2-3, 277–281.

[17] Yang, Z., Rao, Z., Ling, Y.S., and Zhu, Y.N., 2008, USA Patent 20090297587.



DOI: https://doi.org/10.22146/ijc.21413

Article Metrics

Abstract views : 1818 | views : 2884


Copyright (c) 2011 Indonesian Journal of Chemistry

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 

Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

Web Analytics View The Statistics of Indones. J. Chem.