SYNTHESIZE AND CITOTOXICITY TEST OF SEVERAL COMPOUNDS OF MONO PARA-HIDROXY CHALCON

Indyah Sulistyo Arty

doi:10.22146/ijc.21489

SYNTHESIZE AND CITOTOXICITY TEST OF SEVERAL COMPOUNDS OF MONO PARA-HIDROXY CHALCON

https://doi.org/10.22146/ijc.21489

Indyah Sulistyo Arty^(1*)

(1) Chemistry Education Department, FMIPA, Yogyakarta State University, Karangmalang Depok, Yogyakarta 55283
(*) Corresponding Author

Abstract

Five compounds of mono para-hidroxy chalcon were synthesized (TC1, TC2, TC3, TC4, and TC5) and tested their cytotoxicity against HeLa cell and Raji cell. The difference in substituent of TC1 (R₄ =H), TC2 (R₄ = OCH₃), and TC3 (R₄ = F), showed the difference of their citotoxicity against HeLa cell. The citotoxicity of TC1 (LC₅₀ = 16.08 µg/mL) ≈ TC3 (LC₅₀ = 13.37 µg/mL), but the substituent difference of TC2 (LC₅₀ = 147.43 µg/mL), decreasing it citotoxicity 10 times. Like wise their citotoxicity against Raji cell of TC1 (LC₅₀ = 36.44 µg/mL) ≈ TC3 (LC₅₀ = 30.46 µg/mL), but the substituent difference of TC2 (LC₅₀ = 468.94 µg/mL), decreasing it citotoxicity activity 15 times. Nevertheless the strength of citotoxicity TC4 (LC₅₀ = 98.74 µg/mL) and TC5 (LC₅₀ = 110.97 µg/mL) against Raji cell are stronger than the citotoxicity of two of them against HeLa cell (LC₅₀ of TC4 = none, LC₅₀ of TC5 = 576.53 µg/mL).

Keywords

mono para-hidroxy chalcon; HeLa cell; Raji cell; citotoxicity activity

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DOI: https://doi.org/10.22146/ijc.21489