STABILITY OF KETOPROFEN COATED BY CHITOSAN-GUAR GUM GEL

https://doi.org/10.22146/ijc.21504

Purwantiningsih Sugita(1*), Bambang Srijanto(2), Budi Arifin(3), Ellin Vina Setyowati(4)

(1) Department of Chemistry, Bogor Agricultural Institute, Jl. Agatis Kampus IPB Darmaga Bogor 16680
(2) Agency Assessment and Application of Technology, Jl. M. H. Thamrin No. 8 Jakarta
(3) Department of Chemistry, Bogor Agricultural Institute, Jl. Agatis Kampus IPB Darmaga Bogor 16680
(4) Department of Chemistry, Bogor Agricultural Institute, Jl. Agatis Kampus IPB Darmaga Bogor 16680
(*) Corresponding Author

Abstract


The coating stability of ketoprofen by chitosan-guar gum gel has been studied. Into 228.6 mL of 1.75% (w/v) chitosan solution in 1% (v/v) acetic acid, 38.1 mL of guar gum (gg) solution was added with concentration variation of 0.35, 0.55, and 0.75% (w/v) for ketoprofen microcapsules, and stirred with magnetic stirrer until homogenous. Afterwards, 7.62 mL of glutaraldehyde (glu) was added slowly under stirring, with concentrations varied: 3, 3.5, and 4% (v/v). All mixtures were shaked for 20 min for homogenization. Into each microcapsule mixture for ketoprofen, a solution of 2 g of ketoprofen in 250 mL of 96% ethanol was added. Every mixture was then added with 5 mL of 2% Tween-80 and stirred with magnetic stirrer for an hour at room temperature. Conversion of suspension into fine powders/granules (microcapsules) was done by using spray dryer. Every microcapsule formula was packed into capsules, as much as 100 g per capsule. The capsules were contained in 100-mL dark bottles and the bottles were kept in climatic chamber at (40 ± 2) °C and RH (75 ± 5) % for 3 months. The microcapsule stabilities were tested chemically and physically. The result showed that formulation of ketoprofen preparation composed of 1.75% (w/v) chitosan, 0.35% (w/v) gg, and 3.50% (v/v) glu, was relatively the best, with ketoprofen percentage left in microcapsule after 3 months, degradation rate constant, and shelf life of 80.33%, 0.0351 % week-1, and 18.92 months, respectively. Reaction kinetic model for this formula followed Prout-Tompkins equation and the degradation of ketoprofen was seem to follow autocatalytic reaction mechanism controlled by the formation and growth of reaction core.


Keywords


Ketoprofen; chitosan-guar gum gel

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DOI: https://doi.org/10.22146/ijc.21504

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