Purwantiningsih Sugita(1*), Bambang Srijanto(2), Budi Arifin(3), Ellin Vina Setyowati(4)

(1) Department of Chemistry, Bogor Agricultural Institute, Jl. Agatis Kampus IPB Darmaga Bogor 16680
(2) Agency Assessment and Application of Technology, Jl. M. H. Thamrin No. 8 Jakarta
(3) Department of Chemistry, Bogor Agricultural Institute, Jl. Agatis Kampus IPB Darmaga Bogor 16680
(4) Department of Chemistry, Bogor Agricultural Institute, Jl. Agatis Kampus IPB Darmaga Bogor 16680
(*) Corresponding Author


The coating stability of ketoprofen by chitosan-guar gum gel has been studied. Into 228.6 mL of 1.75% (w/v) chitosan solution in 1% (v/v) acetic acid, 38.1 mL of guar gum (gg) solution was added with concentration variation of 0.35, 0.55, and 0.75% (w/v) for ketoprofen microcapsules, and stirred with magnetic stirrer until homogenous. Afterwards, 7.62 mL of glutaraldehyde (glu) was added slowly under stirring, with concentrations varied: 3, 3.5, and 4% (v/v). All mixtures were shaked for 20 min for homogenization. Into each microcapsule mixture for ketoprofen, a solution of 2 g of ketoprofen in 250 mL of 96% ethanol was added. Every mixture was then added with 5 mL of 2% Tween-80 and stirred with magnetic stirrer for an hour at room temperature. Conversion of suspension into fine powders/granules (microcapsules) was done by using spray dryer. Every microcapsule formula was packed into capsules, as much as 100 g per capsule. The capsules were contained in 100-mL dark bottles and the bottles were kept in climatic chamber at (40 ± 2) °C and RH (75 ± 5) % for 3 months. The microcapsule stabilities were tested chemically and physically. The result showed that formulation of ketoprofen preparation composed of 1.75% (w/v) chitosan, 0.35% (w/v) gg, and 3.50% (v/v) glu, was relatively the best, with ketoprofen percentage left in microcapsule after 3 months, degradation rate constant, and shelf life of 80.33%, 0.0351 % week-1, and 18.92 months, respectively. Reaction kinetic model for this formula followed Prout-Tompkins equation and the degradation of ketoprofen was seem to follow autocatalytic reaction mechanism controlled by the formation and growth of reaction core.


Ketoprofen; chitosan-guar gum gel

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[1]   Sutriyo, Joshita, D., and Indah, R., 2005, Majalah Ilmu Kefarmasian, 2, 145-153.

[2]   Berger, J., Reist, M., Mayer, J.M., Felt, O., Peppas, N.A., and Gurny, R., 2004, Eur. J. Pharm. Biopharm., 57, 19-34.

[3]   Yamada, T., Onishi, H., and Machida, Y., 2001, Yakugaku Zasshi, 121, 239-245.

[4]   Wang, T., Turhan, M., and Gunasekaram, S., 2004, Polym Int., 53, 911-918.

[5]   Sugita, P., Sjahriza, A., and Lestari, S.I., 2006, J. Nature, 9, 32-36.

[6]   Sugita, P., Sjachriza, A., and Rachmanita, 2007, J. Alchemy, 6, 1, 57-62.

[7]   Cardenas, A., Monal, W.A., Goycoolea, F.M., Ciapara, I.H., and Peniche, C., 2003, Macromol. Biosci., 3, 535-539.

[8]   Sugita, P., Sjahriza, A., and Wahyono, D., 2006, J. Sains dan Teknologi Indonesia, 8, 3, 133-137.

[9]     Sugita, P., Sjahriza, A., and Utomo, D.W., 2007, Optimization Synthesis of Chitosan-Xanthan Gum Gel for Metal Ion Adsorption. Proceeding 1st International Conference on Chemical Sciences, Innovation in Chemical Science for Better Life, Yogyakarta, Indonesia, 24-25 May 2007

[10] Kshirsagar, N.A., 2000, Indian J. Pharmacol., 32, 54-61.

[11] [AMA] American Medical Association. 1991. Drug Evaluations. Ed. ke-8.

[12] Nata, F., Sugita, P., Sjachriza, A., and Arifin, B., 2007, Diffusion behavior of ketoprofen through chitosan-guar gum membranes. Perilaku Difusi Ketoprofen Melalui Membran Kitosan-Gom Guar. Prosiding Seminar International Conference and Workshop on Basic science and Applied Science. [6-7 Agustus 2007].

[13] Sugita, P., Amelia, F., Srijanto, B., and Arifin, B., 2007c, Perilaku Disolusi Ketoprofen Tersalut Gel Kitosan-Gom guar. Seminar Bersama ITB – UKM Malaysia, Bandung 12-13 Desember 2007

[14] Tong, W.Q., and Zhang, G.G.Z., 2006, Stability and Excipient Compatibility, Paper on Integrated Drug Development Process Course, University of Utah.

[15] Agoes, G., 2001, Studi Stabilitas Sediaan Farmasi, Bandung: Fakultas Teknologi Farmasi Program Pasca Sarjana Institut Teknologi Bandung.

[16] INDIAN PHARMACOPOEIA, 1996, 4th ed., New Delhi: The Controller of Publications, 1, 470.

[17] Saravanan, M., Nataraj, K.S., and Ganesh, K.S., 2003, Chem Pharm Bull 51, 8, 978-983.

[18] Shoaib, M.H., Tazeen, J., Merchant, H.A., and Yousuf, R.I., 2006, J. Pharm. Sci., 19, 119-124.

[19] Levenspiel, O., 1999, Chemical Reaction Engineering, 3rd ed., John Wiley & Sons, New York.


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Indonesian Journal of Chemistry (ISSN 1411-9420 / 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

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