THE SULFONATION STUDY OF REACTION MECHANISM ON PAPAVERINE ALKALOID BY GC-MS AND FT-IR

https://doi.org/10.22146/ijc.21715

I Made Sudarma(1*)

(1) Chemical Laboratory, UPT-MIPA, University of Mataram, Jl. Majapahit 62 Mataram 83125
(*) Corresponding Author

Abstract


The aim of this research was to prove theoretical mechanism reaction on the sulfonation of papaverine alkaloid and the result could be used as a reference on the transformation of these alkaloid to the other derivatives. Theoriticaly sulfonation of papaverine (1) by HO-SO2Cl could produced papaverine sulfonyl chloride (1a). The formation of this product was analyzed by analytical thin layer chromatography GC-MS, and FT-IR. These analysis showed the formation of product (1a) more favorable than the other. Tlc showed product (1a) less polar than papaverine, and supported by GC-MS and infrared which showed molecular ion at m/z 412 due to the presence of -SO2Cl and vibration at 1153,4 dan 1265,2 Cm-1 due to absorption of sulfonyl group.


Keywords


reaction mechanism; sulfonation; papaverine alkaloid

Full Text:

Full Text PDF


References

[1] Tjay, T. H and K. Rahardja. 2002. Obat-obat Penting, Khasiat, Penggunaan, dan Efek-efek Sampingnya, edisi ke lima, PT Gramedia, Jakarta.

[2] Rahardjo S. B., S. Wahyuningsih, and R. N. Damayanti, 2006, Alchemy, 5, 1

[3] Mc. Murry, J., 1992. Organic Chemistry, Third edition, Brooks Publishing Company, California.

[4] Handayani, D. S., 2002. Alchemy, 1, 1

[5] Andrea, E. H., 1989, J. Chem. Educ., 66, 613-614

[6] Sudarma, 2006, Jurnal Penelitian Universitas Mataram, 2, 9, 50 – 54.

[7] Levins P. L., 1968, J. Org. Chem., 33, 2890

[8] Moore, M. and Dalrymple, 1971, Experimental Methods in Organic Chemistry, Saunder Company, Philadelphia.



DOI: https://doi.org/10.22146/ijc.21715

Article Metrics

Abstract views : 3391 | views : 22257


Copyright (c) 2010 Indonesian Journal of Chemistry

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 

Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

Web Analytics View The Statistics of Indones. J. Chem.