* Corresponding Author
OPTIMIZATION OF TIME REACTION AND HYDROXIDE ION CONCENTRATION ON FLAVONOID SYNTHESIS FROM BENZALDEHYDE AND ITS DERIVATIVES
https://doi.org/10.22146/ijc.21825 Sri Handayani(1*), Sunarto, Sunarto,(2), Susila Kristianingrum(3)
(1) Chemistry Education Departement, Faculty of Mathematics and Natural Sciences Yogyakarta State University, Yogyakarta
(2) Chemistry Education Departement, Faculty of Mathematics and Natural Sciences Yogyakarta State University, Yogyakarta
(3) Chemistry Education Departement, Faculty of Mathematics and Natural Sciences Yogyakarta State University, Yogyakarta
(*) Corresponding Author
Abstract
The aim of this research is to determine the optimum time of reaction and concentration of hydroxide ion on chalcone, 4-methoxychalcone and 3,4-dimethoxychalcone synthesis. Chalcone and its derivatives were synthesized by dissolving KOH in ethanol followed by dropwise addition of acetophenone and benzaldehyde. Then, the mixture was stirred for several hours. Three benzaldehydes has been used, i.e : benzaldehyde, p-anysaldehyde and veratraldehyde. The time of reaction was varied for, 12, 18, 24, 30 and 36 hours. Furthermore, on the optimum reaction time for each benzaldehyde the hydroxyl ion concentration was varied from 5,7,9,11 and 13%(w/v). The results of this research suggested that the optimum time of chalchone synthesis was 12 hours, while, 4-methoxychalcone and 3,4-dimethoxychalcone were 30 hours. The optimum concentration of hydroxide ion of chalcone synthesis was 13% and for 4-methoxychalcone and 3,4-dimethoxychalcone were 11%.
Keywords
Full Text:
Full Text PDFReferences
[1] Tommasi, N.D., and Pizza, C., 1997, J. Nat. Prod., 60, 270-273
[2] Orjala, J., Wright, A.D., Behrends, H. Folkers, G. and Sticher, O., 1994, J. Nat. Prod., 57,1,18
[3] Bhattacharyya, J., Batista, J.S. and Almeida, R.N., 1995, Phytochemistry, 38, 277
[4] Diedrich, D.F., 1962, J. Med. Pharm. Chem., 5, 1054
[5] Iinuma, M., Tanka, T., dan Matsuura, S., 1984 , Chem. Phar. Bull , 32 (6), 2296
[6] Alcantara, A.R., Marinas, J.M. and Sinistera, J.V., 1987, Tetrahedron Letter, 28, 1515
[7] Spearing, P., Majestich, G. and Bhattacharya, J., 1997, J. Nat. Prod., 60, 399
[8] Handayani, S., 2000, Sintesis 4’-metoksiflavanon Menggunakan O-Hidroksiasetofenon dan p-Anisaldehida dari Minyak Adas, Thesis, Pascasarjana UGM, Jogjakarta.
[9] Ismiyarto, 1998, Sintesis Senyawa Kalkon dan Flavanon Menggunakan Bahan Dasar Senyawa Turunan Asetofenon dan Benzaldehida, Thesis, Pascasarjana UGM, Jogjakarta
[10] Harborne, J.B., and Mabry, T.J., 1975, The Flavonoid, Academic Press, New York
[11] Shimokoriyama, M, 1957, J. Am. Chem. Soc., 79, 4199
[12] Harborne, J.B., and Mabry, T.J., 1982, The Flavonoid : Advanced in Research, Chapman and Hall, London
[13] Mabry, T.J., Markham, K.R. dan Thomas, M.B., 1970, The Systematic Identification of Flavonoids, Springer – Verlag, New York
[14] Markham, K.R., 1988, Cara Mengidentifikasi Flavonoid, (diterjemahkan oleh Kosasih Padmawinata), Penerbit ITB, Bandung
DOI: https://doi.org/10.22146/ijc.21825
Article Metrics
Abstract views : 2552
| 
views : 4798
Copyright (c) 2010 Indonesian Journal of Chemistry
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.