α-Glucosidase Inhibitory and A Leptospermone Derivative from Rhodomyrtus tomentosa

https://doi.org/10.22146/ijc.40990

Ferlinahayati Ferlinahayati(1*), Daniel Alfarado(2), Eliza Eliza(3), Budi Untari(4)

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Sriwijaya, Jl. Raya Palembang Prabumulih Km 32, Ogan Ilir 30622, South Sumatera, Indonesia
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Sriwijaya, Jl. Raya Palembang Prabumulih Km 32, Ogan Ilir 30622, South Sumatera, Indonesia
(3) Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Sriwijaya, Jl. Raya Palembang Prabumulih Km 32, Ogan Ilir 30622, South Sumatera, Indonesia
(4) Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Sriwijaya, Jl. Raya Palembang Prabumulih Km 32, Ogan Ilir 30622, South Sumatera, Indonesia
(*) Corresponding Author

Abstract


One of the treatments for diabetes mellitus disease is to control blood sugar level using an inhibitor of α-glucosidase enzyme. The methanol extracts of the fruit, stem, and leaves of Rhodomyrtus tomentosa were found significant in inhibiting α-glucosidase with an IC50 value of 20.57, 20.36 and 43.99 μg/mL respectively. The ethyl acetate and n-butanol fractions from the methanol extract of R. tomentosa fruit exhibited the potent inhibition (IC50 13.49 and 19.29 μg/mL) compare to acarbose and n-hexane fraction (IC50 383.68 and 1175.16 μg/mL). A leptospermone derivative, rhodomyrtosone D, was isolated from the ethyl acetate fraction of R. tomentosa fruit. The structure of rhodomyrtosone D was identified based on spectroscopic analysis, as well as comparing with literature data. The α-glucosidase inhibition of rhodomyrtosone D (IC50 110.45 μg/mL) was 3.5 fold more potent than acarbose. Thus, R. tomentosa plant could be potential as a natural resource of α-glucosidase inhibitor.

Keywords


α-glucosidase; Rhodomyrtus tomentosa; antidiabetic; rhodomyrtosone D; ethyl acetate fraction

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DOI: https://doi.org/10.22146/ijc.40990

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