Simple Microfluidic Paper-Based Analytical Device (μ-PAD) Coupled with Smartphone for Mn(II) Detection Using Tannin as a Green Reagent

https://doi.org/10.22146/ijc.82511

Fidelis Nitti(1*), Wendelina Archangela Ati(2), Philiphi de Rozari(3), Pius Dore Ola(4), David Tambaru(5), Luther Kadang(6)

(1) Department of Chemistry, University of Nusa Cendana, Jl. Adi Sucipto, Penfui, Kupang 85001, Indonesia
(2) Department of Chemistry, University of Nusa Cendana, Jl. Adi Sucipto, Penfui, Kupang 85001, Indonesia
(3) Department of Chemistry, University of Nusa Cendana, Jl. Adi Sucipto, Penfui, Kupang 85001, Indonesia
(4) Department of Chemistry, University of Nusa Cendana, Jl. Adi Sucipto, Penfui, Kupang 85001, Indonesia
(5) Department of Chemistry, University of Nusa Cendana, Jl. Adi Sucipto, Penfui, Kupang 85001, Indonesia; School of Chemistry, The University of Melbourne, Masson Road, Parkville 3052, Australia
(6) Department of Chemistry, University of Nusa Cendana, Jl. Adi Sucipto, Penfui, Kupang 85001, Indonesia
(*) Corresponding Author

Abstract


The development of a simple yet greener microfluidic paper-based analytical device (μ-PAD) for on-site detection of Mn(II) in various types of waters using tannin as a natural reagent was described. The μ-PAD consists of twelve detection zones, created on a Whatman Number 1 filter paper by a simple drawing technique using an acrylic watercolor. The detection of Mn(II) was based on the color change on the reaction zone due to the reaction between Mn(II) and the pre-deposited tannin. The μ-PAD image was captured by a portable smartphone detector, and the blue intensity was digitized using a color picker application to generate the reflectance as the analytical response. The proposed method was characterized by a linear dynamic range of 0.05–0.25 mg L−1 with the limit of detection (LOD) for the determination of Mn(II) of 0.026 mg L−1. The other analytical merits of the proposed method, such as precision (RSD, 1.107%), accuracy (E, 6.697%), and recovery (104–112%), were all comparable to the existing spectrophotometric methods. The method’s successful application to natural water samples from manganese mining sites aligns with the reference spectrophotometric method, indicating its good selectivity and accuracy without significant influence of commonly associated interfering ions.


Keywords


microfluidic paper based analytical device (μ-PAD); Mn(II) detection; tannin; green reagent



References

[1] O’Neal, S.L., and Zheng, W., 2015, Manganese toxicity upon overexposure: A decade in review, Curr. Environ. Health Rep., 2 (3), 315–328.

[2] Li, L., and Yang, X., 2018, The essential element manganese, oxidative stress, and metabolic diseases: Links and interactions, Oxid. Med. Cell. Longevity, 2018, 7580707.

[3] Iyare, P.U., 2019, The effects of manganese exposure from drinking water on school-age children: A systematic review, NeuroToxicology, 73, 1–7.

[4] Bouchard, M.F., Surette, C., Cormier, P., and Foucher, D., 2018, Low level exposure to manganese from drinking water and cognition in school-age children, NeuroToxicology, 64, 110–117.

[5] Pfalzer, A.C., and Bowman, A.B., 2017, Relationships between essential manganese biology and manganese toxicity in neurological disease, Curr. Environ. Health Rep., 4 (2), 223–228.

[6] Nádaská, G., Lesny, J., and Michalík, I., 2010, Environmental aspect of manganese chemistry, HEJ, ENV-100702-A.

[7] Huang, H.H., 2016, The Eh-pH diagram and its advances, Metals, 6 (1), 23.

[8] Andreas, R., and Zhang, J., 2016, Fractionation and environmental risk of trace metals in surface sediment of the East China Sea by modified BCR sequential extraction method, Molekul, 11 (1), 42–52.

[9] Kohl, P.M., and Medlar, S.J., 2006, Occurrence of Manganese in Drinking Water and Manganese Control, American Water Works Association, Denver, US.

[10] Xu, X., Yang, S., Wang, Y., and Qian, K., 2022, Nanomaterial-based sensors and strategies for heavy metal ion detection, Green Anal. Chem., 2, 100020.

[11] Kumar, K., Saion, E., Yap, C.K., Balu, P., Cheng, W.H., and Chong, M.Y., 2022, Distribution of heavy metals in sediments and soft tissues of the Cerithidea obtusa from Sepang River, Malaysia, Indones. J. Chem., 22 (4), 1070–1080.

[12] Noviana, E., Ozer, T., Carrell, C.S., Link, J.S., McMahon, C., Jang, I., and Henry, C.S., 2021, Microfluidic paper-based analytical devices: from design to applications, Chem. Rev., 121 (19), 11835–11885.

[13] Almeida, M.I.G.S., Jayawardane, B.M., Kolev, S.D., and McKelvie, I.D., 2018, Developments of microfluidic paper-based analytical devices (μPADs) for water analysis: A review, Talanta, 177, 176–190.

[14] Phansi, P., Janthama, S., Cerdà, V., and Nacapricha, D., 2022, Determination of phosphorus in water and chemical fertilizer samples using a simple drawing microfluidic paper-based analytical device, Anal. Sci., 38 (10), 1323–1332.

[15] Xia, Y., Si, J., and Li, Z., 2016, Fabrication techniques for microfluidic paper-based analytical devices and their applications for biological testing: A review, Biosens. Bioelectron., 77, 774–789.

[16] Martinez, A.W., Phillips, S.T., Butte, M.J., and Whitesides, G.M., 2007, Patterned paper as a platform for inexpensive, low-volume, portable bioassays, Angew. Chem., Int. Ed., 46 (8), 1318–1320.

[17] Rakkhun, W., Jantra, J., Cheubong, C., and Teepoo, S., 2022, Colorimetric test strip cassette readout with a smartphone for on-site and rapid screening test of carbamate pesticides in vegetables, Microchem. J., 181, 107837.

[18] Tambaru, D., Rupilu, R.H., Nitti, F., Gauru, I., and Suwari, S., 2017, Development of paper-based sensor coupled with smartphone detector for simple creatinine determination, AIP Conf. Proc., 1823 (1), 020095.

[19] Yurike, F., Iswantini, D., Purwaningsih, H., and Achmadi, S.S., 2022, Tyrosinase-based paper biosensor for phenolics measurement, Indones. J. Chem., 22 (5), 1454–1468.

[20] Firdaus, M.L., Aprian, A., Meileza, N., Hitsmi, M., Elvia, R., Rahmidar, L., and Khaydarov, R., 2019, Smartphone coupled with a paper-based colorimetric device for sensitive and portable mercury ion sensing, Chemosensors, 7 (2), 25.

[21] Mufidah Sari, P., Daud, A., Sulistyarti, H., Sabarudin, A., and Nacapricha, D., 2022, An application study of membraneless-gas separation microfluidic paper-based analytical device for monitoring total ammonia in fish pond water using natural reagent, Anal. Sci., 38 (5), 759–767.

[22] Meredith, N.A., Volckens, J., and Henry, C.S., 2017, Paper-based microfluidics for experimental design: Screening masking agents for simultaneous determination of Mn(II) and Co(II), Anal. Methods, 9 (3), 534–540.

[23] Kamnoet, P., Aeungmaitrepirom, W., Menger, R.F., and Henry, C.S., 2021, Highly selective simultaneous determination of Cu(II), Co(II), Ni(II), Hg(II), and Mn(II) in water samples using microfluidic paper-based analytical devices, Analyst, 146 (7), 2229–2239.

[24] Lee, S.A., Lee, J.J., You, G.R., Choi, Y.W., and Kim, C., 2015, Distinction between Mn(III) and Mn(II) by using a colorimetric chemosensor in aqueous solution, RSC Adv., 5 (116), 95618–95630.

[25] Yue, J., Lv, Q., Wang, W., and Zhang, Q., 2022, Quantum-dot-functionalized paper-based device for simultaneous visual detection of Cu(II), Mn(II), and Hg(II), Talanta Open, 5, 100099.

[26] Das, A.K., Islam, M.N., Faruk, M.O., Ashaduzzaman, M., and Dungani, R., 2020, Review on tannins: Extraction processes, applications and possibilities, S. Afr. J. Bot., 135, 58–70.

[27] Fraga-Corral, M., García-Oliveira, P., Pereira, A.G., Lourenço-Lopes, C., Jimenez-Lopez, C., Prieto, M.A., and Simal-Gandara, J., 2020, Technological application of tannin-based extracts, Molecules, 25 (3), 614.

[28] Shirmohammadli, Y., Efhamisisi, D., and Pizzi, A., 2018, Tannins as a sustainable raw material for green chemistry: A review, Ind. Crops Prod., 126, 316–332.

[29] Üçer, A., Uyanik, A., and Aygün, Ş.F., 2006, Adsorption of Cu(II), Cd(II), Zn(II), Mn(II) and Fe(III) ions by tannic acid immobilised activated carbon, Sep. Purif. Technol., 47 (3), 113–118.

[30] Bacelo, H.A.M., Santos, S.C.R., and Botelho, C.M.S., 2016, Tannin-based biosorbents for environmental applications – A review, Chem. Eng. J., 303, 575–587.

[31] Das, S., and Bhatia, R., 2022, Paper-based microfluidic devices: Fabrication, detection, and significant applications in various fields, Rev. Anal. Chem., 41 (1), 112–136.

[32] Dhavamani, J., Mujawar, L.H., and El-Shahawi, M.S., 2018, Hand drawn paper-based optical assay plate for rapid and trace level determination of Ag+ in water, Sens. Actuators, B, 258, 321–330.

[33] Anushka, A., Bandopadhyay, A., and Das, P.K., 2022, Paper based microfluidic devices: a review of fabrication techniques and applications, Eur. Phys. J.: Spec. Top., 232 (6), 781–815.

[34] Grudpan, K., Kolev, S.D., Lapanantnopakhun, S., McKelvie, I.D., and Wongwilai, W., 2015, Applications of everyday IT and communications devices in modern analytical chemistry: A review, Talanta, 136, 84–94.

[35] Jain, B., Jain, R., Jha, R.R., Bajaj, A., and Sharma, S., 2022, A green analytical approach based on smartphone digital image colorimetry for aspirin and salicylic acid analysis, Green Anal. Chem., 3, 100033.

[36] Schlesner, S.K., Voss, M., Helfer, G.A., Costa, A.B., Cichoski, A.J., Wagner, R., and Barin, J.S., 2022, Smartphone-based miniaturized, green and rapid methods for the colorimetric determination of sugar in soft drinks, Green Anal. Chem., 1, 100003.

[37] David, T., Grandivoriana, N.A., and Fidelis, N., 2018, Digital-based image detection system in simple silver nanoparticles-based cyanide assays, Res. J. Chem. Environ, 22, 10–14.

[38] Birch, N.C., and Stickle, D.F., 2003, Example of use of a desktop scanner for data acquisition in a colorimetric assay, Clin. Chim. Acta, 333 (1), 95–96.

[39] Huang, C.N., Lum, B., and Liu, Y., 2018, Smartphone-assisted colorimetric analysis of manganese in steel samples, Curr. Anal. Chem., 14 (6), 548–553.

[40] Miller, J.C., and Miller, J.N., 1988, Statistics for Analytical Chemistry, 2nd Ed., Ellis Horwood Ltd., Chichester.

[41] Zhang, L.L., Cattrall, R.W., and Kolev, S.D., 2011, The use of a polymer inclusion membrane in flow injection analysis for the on-line separation and determination of zinc, Talanta, 84 (5), 1278–1283.



DOI: https://doi.org/10.22146/ijc.82511

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