Synthesis, Characterization and Biological Activity of New Oleander Complexes against Bacteria Found in Polluted Water

Zainab Sabeer Abdulsada; Sahar Sabeeh Hassan; Sanaa Hitur Awad

doi:10.22146/ijc.84332

Synthesis, Characterization and Biological Activity of New Oleander Complexes against Bacteria Found in Polluted Water

https://doi.org/10.22146/ijc.84332

Zainab Sabeer Abdulsada^(1*), Sahar Sabeeh Hassan⁽²⁾, Sanaa Hitur Awad⁽³⁾

(1) Ministry of Environment, Baghdad 10062, Iraq
(2) Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad 10071, Iraq
(3) Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad 10071, Iraq
(*) Corresponding Author

Abstract

Natural polymers are often non-toxic, biodegradable, biocompatible, and safe. A novel ligand was synthesized as a natural polymer using chitosan and oleander plant extract [(2R,3S,4R,5S)-5-(acetoxyamino)-4-hydroxy-3,6-dimethoxytetrahydro-2H-pyran-2-yl) methyl (16R)-3-(((2S,4S,5R)-4-methoxy-2,5-dimethyltetrahydro-2H-pyran-2-yl)oxy-10,13,16-trimethyl-17-(5-oxo-2,5-dihydrofuran-3-yl) hexadecahydro-14H-cyclopenta [a] phenanthren-14-yl) phthalate] (Chitosan-Ph-Oleander). This ligand and its complexes with several metals (Cr⁺³, Mn⁺², Fe⁺³, Ni⁺², Cu⁺², Zn⁺²) were characterized using FTIR, UV-visible and ¹H-NMR spectroscopy, as well as by molar conductivity, magnetic moment, and TGA analysis. The biological activity for the prepared polymer and its complexes was studied to inhibit the effectiveness of some bacteria found in polluted water taken from hospitals wastewater. The effectiveness of inhibition was tested on Fusarium oxysporum fungus, which causes wilting, rotting and seedling death diseases in various types of plants. The elemental and spectral investigation results showed that all prepared compounds had octahedral geometry. Compared to the free ligand, all metal complexes showed discernible antibacterial activity. The zinc(II) complex, in comparison to other metal complexes, showed higher antibacterial activity against Faecal streptococci bacteria (G⁺) and Pseudomonas aeruginosa bacteria (G⁻). In addition, the inhibition rate of the effectiveness of the F. oxysporum fungus reached ~50%.

Keywords

chitosan; contaminated water; inhibiting effectiveness; natural polymer

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DOI: https://doi.org/10.22146/ijc.84332