Hydrophilic Surfaces Turning of Graphene Nano Platelets by 1,3,6-Trihydroxyxanthone: π–π Stacking Interaction Affair in 2-D

https://doi.org/10.22146/ijc.89894

Emmy Yuanita(1*), Sirojuttolibin Sirojuttolibin(2), Ni Komang Tri Dharmayani(3), Maria Ulfa(4), Maulida Septiyana(5), Sudirman Sudirman(6)

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Mataram, Jl. Majapahit No. 62, Mataram 83115, Indonesia
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Mataram, Jl. Majapahit No. 62, Mataram 83115, Indonesia
(3) Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Mataram, Jl. Majapahit No. 62, Mataram 83115, Indonesia
(4) Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Mataram, Jl. Majapahit No. 62, Mataram 83115, Indonesia
(5) Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Mataram, Jl. Majapahit No. 62, Mataram 83115, Indonesia
(6) Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Mataram, Jl. Majapahit No. 62, Mataram 83115, Indonesia
(*) Corresponding Author

Abstract


Graphene nanoplatelet (GNP) has a good potential to be developed as a drug carrier material. In this study, the interaction of GNP with one type of drug, namely 1,3,6-trihydroxyxanthone (THX), has been studied. The results of XRD analysis and FTIR uptake show an excellent interaction between THX and GNP through the π–π stacking channel. This interaction makes the GNP surface more polar and soluble in the aqueous media. THX-graphene shows physical and chemical stabilities, where THX can be released under specific and controlled conditions. The results of this study show the potential of utilizing graphene as a drug carrier material for more specific disease targets with a longer drug release time.

Keywords


trihydroxyxanthones; graphene; π–π stacking; polar surfaces

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DOI: https://doi.org/10.22146/ijc.89894

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