Synthesis, Characterization, and Antibacterial Activity of Plant-Derived Zinc Oxide Nanostructure Using  Lavandula angustifolia  and  Phyllanthus niruri  Extracts

Dhiya Fakhirah; Tya Aisha Magfira; Aulia Sukma Hutama; Abdi Wira Septama; Faiza Maryani; Fransiska Sri Herwahyu Krismastuti

doi:10.22146/ijc.93293

Synthesis, Characterization, and Antibacterial Activity of Plant-Derived Zinc Oxide Nanostructure Using Lavandula angustifolia and Phyllanthus niruri Extracts

https://doi.org/10.22146/ijc.93293

Dhiya Fakhirah⁽¹⁾, Tya Aisha Magfira⁽²⁾, Aulia Sukma Hutama⁽³⁾, Abdi Wira Septama⁽⁴⁾, Faiza Maryani⁽⁵⁾, Fransiska Sri Herwahyu Krismastuti^(6*)

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia
(3) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia
(4) Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), KST BJ Habibie, Setu, Tangerang Selatan 15314, Indonesia
(5) Research Center for Chemistry, National Research and Innovation Agency (BRIN), KST BJ Habibie, Setu, Tangerang Selatan 15314, Indonesia
(6) Research Center for Chemistry, National Research and Innovation Agency (BRIN), KST BJ Habibie, Setu, Tangerang Selatan 15314, Indonesia
(*) Corresponding Author

Abstract

In recent years, green synthesized nanomaterials have garnered wide interest due to its inherent features like rapidity, cost-effectiveness, and environmentally friendly technique. The green synthesis of Zinc oxide nanostructures (n-ZnO) using two kinds of plant extract, lavender (Lavandula angustifolia) and meniran (Phyllanthus niruri), were discussed and their antibacterial activities were compared. Characterization by means of X-ray diffraction (XRD), Fourier transform infrared (FTIR), and field emission-scanning electron microscopy/energy dispersive X-ray spectroscopy (FE-SEM/EDS) were used to confirm the successful formation of n-ZnO using both plant extracts. The antibacterial activity of the n-ZnO synthesized from two different plant extracts was tested against Klebsiella pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA). The results show that both n-ZnO has antibacterial activity against MRSA. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values for n-ZnO synthesized from meniran extract were 78 and 156 mg/mL, respectively, while MIC and MBC values for n-ZnO synthesized from lavender extract were 156 and 312 mg/mL, respectively. These results confirm that the n-ZnO prepared from meniran extract is more effective in inhibiting MRSA than the n-ZnO prepared from lavender extract. This study proves that plant-based n-ZnO has anti-microbial activities and may serve as antimicrobial therapeutics.

Keywords

lavender; meniran; n-ZnO; MRSA, Klebsiella pneumoniae

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DOI: https://doi.org/10.22146/ijc.93293