Preparation, Structural Identification, and Biomedical Evaluation of Some New Complexes

Alyaa Khider Abbas; Asmaa Edrees Fadhil

doi:10.22146/ijc.95759

Preparation, Structural Identification, and Biomedical Evaluation of Some New Complexes

https://doi.org/10.22146/ijc.95759

Alyaa Khider Abbas^(1*), Asmaa Edrees Fadhil⁽²⁾

(1) Department of Chemistry, College of Science, University of Baghdad, Al Jadriya Street, Baghdad 10071, Iraq
(2) College of Pharmacy, Al-Turath University, Al Mansour Street, Baghdad 10013, Iraq
(*) Corresponding Author

Abstract

A new nano azo ligand, [2-amino-6-oxo-6,7-dihydro-1H-purin-8-yl)diazenyl)nitrobenzene (AH), and its Ag(I), Cu(II), and Zn(II) complexes were successfully synthesized and characterized using elemental analyses, magnetic susceptibility, molar conductance, and spectroscopic techniques (FTIR, UV-vis, ¹H-NMR), along with thermal analysis. FTIR confirmed the ligand acts as a neutral N,N-bidentate. The metal-to-ligand ratio was determined to be 1:1 for Ag(I) and Zn(II) complexes and 1:2 for the Cu(II) complex. Stability constants and Gibbs free energy, assessed via spectrophotometry, indicated high stability for all complexes. SEM and X-ray diffraction revealed nanoscopic properties for the Ag(I) and Cu(II) complexes. The antimicrobial activity against Staphylococcus aureus, Klebsiella pneumoniae, and Candida albicans species showed good efficiency compared to reference drugs. The ligand also exhibited moderate antioxidant activity using the DPPH assay. Additionally, the Zn(II) complex demonstrated effective anti-inflammatory activity, promoting wound healing within 14 days, compared to 16 days with silver sulfadiazine and 18 days without treatment.

Keywords

hypoxanthine-azo ligand; anti-microbial activity; antioxidant; burn healing

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DOI: https://doi.org/10.22146/ijc.95759