UJI IRITASI MATERIAL COBALT CHROMIUM SEBAGAI MATERIAL DASAR BONE PLATE UNTUK REKONSTRUKSI MANDIBULA

https://doi.org/10.22146/teknosains.8162

Dian Permata Sari(1), Eti Nurwening Sholihah(2), Muhammad Kusumawan Herliansyah(3*)

(1) Gadjah Mada University
(2) Fakultas Kedokteran, Universitas Gadjah Mada
(3) Department of Mechanical Engineering, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


The mandibular bone defect can cause speech disorder, mastication malfunction, and aesthetic problems. The application of plate for mandibular reconstruction can improve the function disorder. Plate material must be strong, resilient, able to adapt to the bone surface, and has good biocompatibility. Cobalt chromium is a cobalt base alloys are often used for implant materials. It has good mechanical properties, biocompatibility, and corrosion resistance. The aim of this study was to investigate the effect of local irritation and tissue response on material cobalt chromium. This study used three albino rabbits were injected by the material powder in polar and nonpolar solvents with intracutaneous injection method, then the treatments were observed on the first, second, and third days. Erythema and edema that occurs were scored based on grading system for intracutaneous (intradermal) reactions. Friedmann test showed no significant difference between treatment groups (p> 0.05). The results showed that erythema and edema arising from irritant reactions are still within normal limits. Irritation occurs due to the release of cobalt chromium ions which trigger hypersensitivity reactions and result in systemic immunity.

Keywords


Cobalt Chromium; Intracutaneous; Irritation; Mandibular Reconstruction

Full Text:

PDF


References

Anderson, J. M. 2001. "Biological response to materials." Annu. Rev. Matter. Res, 31(1):81-110.

Baldo, B.A., dan N.H. Pham. 2013. “Drug Allergy: Clinical Aspects, Diagnosis, Mechanisms.” Structure-Activity Relationships, DOI 10.1007/978-1-4614-7261-2_2.

Behl, B., I. Papageorgiou, C. Browna, R. Hall, J.L. Tipper, J. Fisher, dan E. Ingham. 2013. “Biological Effects of Cobalt-Chromium Nanoparticles and Ions on Dural Fibroblasts and Dural Epithelial Cells.” Biomaterials, 34: 3547-58.

Beumer, J., T. A. Curtis, dan D. N. Firtell. 1996. Maxillofacial Rehabilitation Prosthodontic and Surgical Considerations. C.V. Mosby Company.

Deepak, M. 2011. “Comparison of Titanium Bone Plates and Screws vs. Stainless Steel Bone Plates and Screws in the Management of Mandibular Fractures-A Long Term Clinical Study.” International Journal of Clinical Dental Science.

Disegi, J. A. dan L. Eschbach. 2000. “Stainless steel in Bone Surgery.” Injury, 2-6.

Erdmann, N., A. Bondarenko, M. Hewicker-Trautwein, N. Angrisani, J. Reifenrath, A. Lucas, dan A. Meyer-Lindenberg. 2010. “Evaluation of the soft tissue biocompatibility of MgCa0.8 and surgical steel 316L in vivo: a comparative study in rabbits.” BioMedical Engineering Online, 9:63.

Geurtsen, W. (2002), “Biocompatibility of dental casting alloys." Critical Reviews in Oral Biology & Medicine, 13(1):74-84.

Frazier ME, dan TK. Andrews. 1979. In vitro Clonal Growth Assay for Evaluating Toxicity of Metal Salts. Dalam Trace Metals in Health and Disease (ed. N. Karash). New York: Raven Press.

Handayani, F., 2011, “Kelinci Sebagai Tema Dalam Meningkatkan Karya Seni Grafis.” Tugas Akhir. Surakarta: Universitas Sebelas Maret.

Hunter, J. 2008. “Subcutaneous Injection Techniques.” Nursing Standard, 22(21).

International Organization for Standardization. 2010. International Standard 10993 Biological evaluation of medical devices - Part 10: Tests for irritation and skin sensitization. Switzerland.

Ionescu, R., M. Mardare, A. Dorobantu, S. Vermesan, E. Marinescu, R. Saban, I. Antoniac, D. N. Ciocan, dan M. Ceausu. 2014. “Correlation Between Materials, Design and Clinical Issues in the Case of Associated Use of Different Stainles Steels as Implan Materials.” Key Engineering Materials, 583: 41-44.

Jantzen C, Jorgensen H L, Duus B R, Sporring S L, Lauritzen J B. 2013. “Chromium and cobalt ion concentrations in blood and serum following various types of metal-on-metal hip arthroplasties: a literature overview.” Acta Orthop, 84 (3): 229-36.

Manivasagam, G., D. Dhinasekaran, dan A. Rajamanickam. 2010. “Biomedical Implans: Corrosion and its Prevention.” Recent Patents on Corrosion Science, 2: 40-54.

Marti, A. 2000. “Cobalt-base alloys used in bone surgery.” International Journal of the Care of the Injured, Elsevier, 31.

Melillo, A. 2007. “Rabbit Clinical Pathology” Journal of Exotic Pet Medicine, 16 (3): 135-145.

Nicholson, JW. 2002. The Chemistry of Medical and Dental Materials. Cambridge: Royal Society of Chemistry.

Okazakia, Y., dan E. Gotoh. 2008. “Metal Release from Stainless steel, Co–Cr–Mo–Ni– Fe and Ni–Ti alloys in Vascular Implans.” J Cor Sci. 50(12): 3429-38.

Okoje, V. N., O. S. Obimakinde, J. T. Arotiba, A. O. Fasola, S. O. Ogunlade, dan A. E. Obiechina. 2012. “Mandibular defect reconstruction with nonvascularized iliac crest bone graft.” Nigerian Journal of Clinical Practice, 15.

Park, J. B., dan J. D. Bronzino. 2003. Metalis Biomaterials in Biomaterials: Principle and Applications, editors: Joon B Park and Joseph D Bronzino. New York: CRC Press.

Peterson, L. Minas, T. Brittberg, M, dan Lindahl, A. 2003. "Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation: results at two to ten years." J Bone Joint Surg Am, 85:17-24.

Prein, J., 1998, Manual of Internal Fixation in the Cranio-Facial Skeleton. Springer Science & Business Media.

Prasetyo A. 2010. “Pengaruh Variasi Kandungan Silikon terhadap Korosi Paduan Kobalt (ASTM F 75) Hasil Metalurgi Serbuk dalam Larutan Artificial Blood Plasma dengan Teknik Polarisasi Potensiodinamik dan Teknik Exposure.” Tesis, Jakarta: Universitas Indonesia.

Samuelson, D. A. 2007. Textbook of Veterinary Histology. St. Louis: Saunders Elsevier.

Shockley, WW., MC. Weissler, dan HC. Pillsbury. 1991. Immediate mandibular replacement using reconstruction plates. Arch Otolaryngol Head Neck Surgery. 117(7):745-9.

Vinardell, M.P., dan M. Mitjans. 2008. “Alternative Methods for Eye and Skin Irritation Tests: An Overview.” Journal of Pharmaceutical Science, 97 (1):46- 59.

Virtanen, S., I. Milosev, E. Gomez-Barrena, R. Trebse, J. Salo, dan Y. T. Konttinen. 2008. “Special Modes of Corrossion Under Physiological and Simulated Physiological Conditions.” Acta Biomaterial, 4(3):468-76.



DOI: https://doi.org/10.22146/teknosains.8162

Article Metrics

Abstract views : 2795 | views : 5711

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2018 Dian Permata Sari

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.




Copyright © 2024 Jurnal Teknosains     Submit an Article        Tracking Your Submission

Editorial Policies       Publishing System       Copyright Notice       Site Map       Journal History      Visitor Statistics     Abstracting & Indexing