Anti-hepatitis B surface (anti-HBs) seroprotection in children with acute lymphoblastic leukemia post hepatitis B vaccination in Indonesia
https://doi.org/10.19106/JMedScie004601201402
. Yustinah
(1*) , Nenny Sri Mulyani
(2) , Roni Naning
(3)
(1) Fatima District Hospital, Ketapang District, West Kalimantan
(2) Department of Pediatrics, Faculty of Medicine Universitas Gadjah Mada/Dr. Sardjito General Hospital Yogyakarta
(3) Department of Pediatrics, Faculty of Medicine Universitas Gadjah Mada/Dr. Sardjito General Hospital Yogyakarta
(*) Corresponding Author
Abstract
Children with acute lymphoblastic leukemia (ALL) receiving chemotherapy are at high risk for developing hepatitis B infection. Protective effect of hepatitis B vaccination in children with ALL in Indonesia has not been investigated yet. The aim of study was to determine the proportion difference of anti-HBs seroprotection between children with ALL and without malignancy post hepatitis B vaccination. We had conducted a case-control study from January to February 2012 at Dr. Sardjito General Hospital, Yogyakarta. We ascertained 1-15 years old children with ALL receiving chemotherapy and without malignancy who had hepatitis B vaccination. Sixty seven children were included in this study. Anti-HBs seroprotection level was measured using an enzyme-linked immunosorbent assay (ELISA). The results were analyzed using Chi-square test. Twenty one children (65.6%) with ALL and 13 children (37.1%) without malignancy showed anti-HBs seroprotection. The difference was statistically significant with p-value of 0.020 (prevalence ratio [PR]=0.3; 95% CI=0.11-0.84). Both groups showed no significantly difference of anti-HBs seroprotection according to either female gender, risk classification, or phase of chemotherapy with p-value of 0.38 (PR =4; 95% CI=1.05-15.2), 0.248 (PR =3.37; 95% CI=0.58-19.6) or 0.214, respectively. In conclusion, the proportion of anti-HBs seroprotection in children with ALL is higher than those without malignancy.
Keywords
anti-HBs seroprotection level – post hepatitis B vaccination – acute lymphoblastic leukemia – Indonesian cases
DOI:
https://doi.org/10.19106/JMedScie004601201402
Article Metrics
Abstract views : 1897
|
views : 2202
Copyright (c) 1970 . Yustinah, Nenny Sri Mulyani, Roni Naning
This work is licensed under a
Creative Commons Attribution-NonCommercial 4.0 International License .
piala88 slot/
https://heatbeatmiami.com/
judi bola slot gacor
slot gacor
href="https://whiteroseshub.com/">https://whiteroseshub.com/
mallbet login
mallbet login
mallbet login
<div class="statcounter"><a title="real time web analytics" href="https://statcounter.com/" target="_blank"><img class="statcounter" src="https://c.statcounter.com/10697571/0/23d82b78/0/" alt="real time web analytics"></a></div> <div class="statcounter"><a title="shopify visitor statistics" href="http://statcounter.com/shopify/" target="_blank"><img class="statcounter" src="http://c.statcounter.com/10697571/0/23d82b78/0/" alt="shopify visitor statistics"></a></div>