Anti-hepatitis B surface (anti-HBs) seroprotection in children with acute lymphoblastic leukemia post hepatitis B vaccination in Indonesia

. Yustinah(1*), Nenny Sri Mulyani(2), Roni Naning(3)

(1) Fatima District Hospital, Ketapang District, West Kalimantan
(2) Department of Pediatrics, Faculty of Medicine Universitas Gadjah Mada/Dr. Sardjito General Hospital Yogyakarta
(3) Department of Pediatrics, Faculty of Medicine Universitas Gadjah Mada/Dr. Sardjito General Hospital Yogyakarta
(*) Corresponding Author


Children with acute lymphoblastic leukemia (ALL) receiving chemotherapy are at high risk for
developing hepatitis B infection. Protective effect of hepatitis B vaccination in children with
ALL in Indonesia has not been investigated yet. The aim of study was to determine the proportion
difference of anti-HBs seroprotection between children with ALL and without malignancy post
hepatitis B vaccination. We had conducted a case-control study from January to February 2012
at Dr. Sardjito General Hospital, Yogyakarta. We ascertained 1-15 years old children with ALL
receiving chemotherapy and without malignancy who had hepatitis B vaccination. Sixty seven
children were included in this study. Anti-HBs seroprotection level was measured using an
enzyme-linked immunosorbent assay (ELISA). The results were analyzed using Chi-square test.
Twenty one children (65.6%) with ALL and 13 children (37.1%) without malignancy showed
anti-HBs seroprotection. The difference was statistically significant with p-value of 0.020
(prevalence ratio [PR]=0.3; 95% CI=0.11-0.84). Both groups showed no significantly difference
of anti-HBs seroprotection according to either female gender, risk classification, or phase of
chemotherapy with p-value of 0.38 (PR =4; 95% CI=1.05-15.2), 0.248 (PR =3.37; 95%
CI=0.58-19.6) or 0.214, respectively. In conclusion, the proportion of anti-HBs seroprotection
in children with ALL is higher than those without malignancy.


anti-HBs seroprotection level – post hepatitis B vaccination – acute lymphoblastic leukemia – Indonesian cases


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