Effects of valsartan compared with telmisartan in reducing insulin resistance on type 2 diabetes mellitus (T2DM) patients with hypertension

https://doi.org/10.19106/JMedSci005302202102

Hemi Sinorita(1*), Luthfan Budi Purnomo(2), R.Bowo Pramono(3)

(1) Division of Endocrinology and Metabolic, Department of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital Yogyakarta, Indonesia.
(2) Division of Endocrinology and Metabolic, Department of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital Yogyakarta, Indonesia.
(3) Division of Endocrinology and Metabolic, Department of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital Yogyakarta, Indonesia.
(*) Corresponding Author

Abstract


Insulin resistance is a major risk factor for patients with type 2 diabetes
mellitus (T2DM). Telmisartan and valsartan are angiotensin II type I receptor
blockers (ARBs) that are often used in patients with metabolic syndrome and
T2DM. This study aimed to compare the effect of valsartan and telmisartan in
reducing insulin resistance on T2DM with hypertension. Patients of T2DM were
open-label screened at the Endocrinology Policlinic, Department of Internal
Medicine, Dr. Sardjito General Hospital, Yogyakarta, and then randomized into
two groups. The first group received valsartan 80 mg per day up to 160 mg per
day, the second group received telmisartan 40 mg per day up to 80 mg per day
in addition with life-style modifying and diabetes therapy. Homeostasis model
assessment of insulin resistance (HOMA-IR), triglyceride and HDL cholesterol
levels of patients were measured before and after receiving telmisartan and
valsartan for 12 weeks. A total of forty-nine outpatients were involved in this
study comprised of 25 female patients (51%) and 24 male patients (49%) with
27 patients (55.1%) received telmisartan and 22 patients (44.9%) received
valsartan as the hypertension therapy. No significantl difference were observed
between telmisartan group compared with valsartan group in HOMA-IR (14.01
± 16.39 vs. 5.31 ± 3.51; p=0.053), triglyceride levels (165.71 ± 94.70 vs 144.41 ±
48.33 mg/dL; p=0.620), HDL-C level (48.57 ± 9.78 vs 49.24 vs 49.24 ± 12.56 mg/dL;
p=0.999). In conclusion, telmisartan demonstrated no difference compared to
valsartan in reducing insulin resistance on T2DM patients with hypertension.


Keywords


valsartan; telmisartan; insulin resistance; T2DM; hypertension;

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DOI: https://doi.org/10.19106/JMedSci005302202102

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