Antimicrobial activity of bioactive compounds isolated from Swietenia mahagoni (L) Jacq. against Staphylococcus aureus and Pseudomonas aeruginosa

Handry Darussalam,; Titik Nuryastuti; . Mursiti; . Mustofa

doi:10.19106/JMedScie004604201402

Antimicrobial activity of bioactive compounds isolated from Swietenia mahagoni (L) Jacq. against Staphylococcus aureus and Pseudomonas aeruginosa

https://doi.org/10.19106/JMedScie004604201402

Handry Darussalam,^(1*), Titik Nuryastuti⁽²⁾, . Mursiti⁽³⁾, . Mustofa⁽⁴⁾

(1) Health Polytechnic of East Kalimantan, Minitry of Health,
(2) Department of Microbiology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta,
(3) Department of Chesmistry, Universitas Negeri Semarang, Semarang,
(4) Department of Pharmacology and Therapy, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia
(*) Corresponding Author

Abstract

Widespread bacterial resistance has led to more difficult to treat infectious diseases with available
antibiotics. Therefore, new antibiotics are needed face of the growing antibiotic resistance. Swietenia
mahagoni (L.) Jacq. is one of potential medicinal plants as a source new antibiotics. Five compounds
have been isolated from an ethanolic extract of S. mahagoni (L.) Jacq., however its antimicrobial
activity has not been investigated, yet. This study was conducted to evaluate the antimicrobial
activity of these compounds. Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal
Concentration (MBC) were determined against Staphylococcus aureus and Pseudomonas aeruginosa
strains. Among five compounds tested, compound 3 (3,4,5,6,7-pentaethyl-1-methoxy-1H-indazole)
and compound 4 (5-ethyl-6-methoxymethyl-2-methyl-1,2-dihydropyridine) were found to be active
against the bactrial strains tested with the MICs and MBCs values ranged from 50 to 100 μg/mL. In
conclusion, among five compounds isolated from S. mahagoni (L.) Jacq., compound 3 and 4
showed moderate antimicrobial activity against S. aureus and P. aeruginosa strains.