ISOLATION AND PRESENCE OF ANTIMALARIAL ACTIVITIES OF MARINE SPONGE Xestospongia sp.

https://doi.org/10.22146/ijc.21276

Murtihapsari Murtihapsari(1*), Apriani Sulu Parubak(2), Bertha Mangallo(3), Wiwied Ekasari(4), Puji Budi Asih(5), Ayu Indah Lestari(6)

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Papua State University, Jl. Gunung Salju Kampus Amban Manokwari, West Papua 98314
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Papua State University, Jl. Gunung Salju Kampus Amban Manokwari, West Papua 98314
(3) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Papua State University, Jl. Gunung Salju Kampus Amban Manokwari, West Papua 98314
(4) Faculty of Pharmacy, Airlangga University, Kampus B Unair, Jl. Dharmawangsa Dalam Surabaya East Java 60286
(5) Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, Jakarta
(6) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Papua State University, Jl. Gunung Salju Kampus Amban Manokwari, West Papua 98314
(*) Corresponding Author

Abstract


Plasmodium falciparum, the agent of malignant malaria, is one of mankind's most severe scourges, mainly in the tropic world. Efforts to develop preventive vaccines or remedial drugs are handicapped by the parasite's rapid evolution of drug resistance. Here, we presented an advance work on examination of antimalarial component from marine life of Xestospongia sp., the study is based on hexane extraction method. The premier result, we obtained five fractions. Among these five fractions, the fourth has the most potent inhibitory against the growth of P. falciparum 3D7 with an IC50: 7.13 µg/mL. A compiled spectrum analysis, FTIR, 1H-NMR and GC-MS, revealed that the fourth fraction consisted abundantly of two secondary metabolites such as flavonoids and triterpenoids. Finally, our results suggest a plausible structure rooted to the base of ibuprofen.

Keywords


sponge; xestospongia; papua; antimalarial

Full Text:

Full Text PDF


References

[1] Hay, S.I., Guerra, C.A., Tatem, A.J., Atkinson, P.M., and Snow, R.W., 2005, Nat. Rev. Microbiol., 3, 1, 81–90.

[2] Kager, P.A., 2002, Trop. Med. Int. Health, 7, 12, 1042–1046.

[3] Bagavan, A., Rahuman, A.A., Kaushik, N.K., and Sahal, D., 2011, Parasitol. Res., 108, 15–22.

[4] White, N.J., 1992, Br. J. Clin. Pharmacol., 34, 1, 1–10.

[5] WHO, 2011, http://www.who.int/malaria.20WHO.htm, accessed 10 October 2011.

[6] Hay, S.I., Rogers, D.J., Toomer, J.F., and Snow, R.W., 2000, Trans. R. Soc. Trop. Med. Hyg., 94, 2, 113–127.

[7] Snow, R.W., Guerra, C.A., Noor, A.M., Myint, H.Y., and Hay, S.I., 2005, Nature, 434, 214–217.

[8] Nayyar, G.M., Breman, J.G, Newton P.N., and Herrington, J., 2012, Lancet Infect. Dis., 12, 6, 488–496.

[9] Elyazar, I.R.F., Gething, P.W., Patil A.P., Rogayah, H., Kusriastuti, R., Wismarini, D.M., Tarmizi, S.N., Baird, J.K., and Hay, S.I., 2011, PLoS ONE, 6, 6, e21315.

[10] Nagesha, H.S., Din-Syafruddin, Casey, G.J., Susanti, A.I., Fryauff, D.J., Reeder, J.C., and Cowman, A.F., 2001, Trans. R. Soc. Trop. Med. Hyg., 95, 1, 43–49.

[11] Suwanarusk, R., Russell, B., Chavchich, M., Chalfein, F., Kenangalem, E., Kosaisavee, V., Prasetyorini, B., Piera, K.A., Barends, M., Brockman, A., Lek-Uthai, U., Anstey, N.M., Tjitra, E., Nosten, F., Cheng, Q., and Price, R.N., 2007, PLoS ONE, 2, 10, e1089.

[12] Baird, J.K, 2004, Antimicrob. Agents Chemother., 48, 11, 4075–4083.

[13] Klein, E.Y., Smith, D.L., Ramanan, L.R., and Simon, L., 2012, Proc. R. Soc. B, 279, 1743, 3834–3842.

[14] Goldberg, D.E., Siliciano, R.F., and Jacobs, W.R.Jr., 2012, Cell, 148, 6, 1271–1283.

[15] Plowe, C.V., 2005, Curr. Top. Microbiol. Immunol., 295, 55–79.

[16] Martin, R.E., Marchetti, R.V., Cowan, A.I., Howitt, S.M., Bröer, S., and Kirk, K., 2009, Science, 325, 5948, 1680–1682.

[17] McGready, R., Cho, T., Keo, N.K., Thwai, K.L., Villegas, L., Looareesuwan, S., White, N.J., and Nosten, F., 2001, Clin. Infect. Dis., 33, 12, 2009–2016.

[18] Tang, C., Godfrey, T., Stawell, R., and Nikpour, M., 2012, Intern. Med. J., 42, 9, 968–978.

[19] Hyde, J.E, 2005, Trends Parasitol., 21, 11, 494–498.

[20] Schlitzer, M., 2007, ChemMedChem, 2, 944–986.

[21] Ross and Flaningan, 2006, http://www.healthatoz.com, accessed 1 January 2010.

[22] Summers, R.L., Nash, M.N., and Martin, R.E, 2012, Cell. Mol. Life Sci., 69, 12, 1967–1995.

[23] Inbaneson, S.J., and Ravikumar, S, 2012, Parasitol. Res., 110, 6, 2255–2262.

[24] Davis, R.A., Buchanan, M.S., Duffy, S., Avery, V.M., Charman, S.A., Charman, W.N., White, K.L., Shackleford, D.M., Edstein, M.D., Andrews, K.T., Camp, D., and Quinn, R.J., 2012, J. Med. Chem., 55, 12, 5851–5858.

[25] McKenna, S.A., Allen, G.R, Suryadi, S., and Rapid Assessment Program 2002, A marine rapid assessment of the Raja Ampat Islands, Papua Province, Indonesia, Washington DC: Conservation International, Center for Applied Biodiversity Science, Dept. of Conservation Biology.

[26] McCarthy, P.J., and Pomponi, S.A., 2004, Mar. Biomed. Res., 1–2.

[27] Allen, G.R., 2008, Aquat. Conserv., 18, 5, 541–556.

[28] Treml, E.A., and Halpin, P.N., 2012, Conserv. Lett., 5, 6, 441–449.

[29] Swantara, I.M.D., Supriyono, A., and Trinoviani, M., 2007, J. Kimia, 1, 1, 67–79.

[30] Harborne, J.B., 1987, Metode Fitokimia, 2nd ed., ITB Bandung, pp.354.

[31] Mills, N., 2006, J. Am. Chem. Soc., 128, 41,
13649–13650.

[32] Buckingham, J., 1993, Dictionary of Natural Products, Vol. 1, Chapman & Hall/CRC, London, p. 8584.

[33] Jin, Z., 2008, J. Med. Chem., 51, 5, 1501.

[34] Morris, S., Bersuder, P., Allchin, C.R., Zegers, B., Boon, J.P., Leonards, P.E., and de Boer, J., 2006, TrAC, Trends Anal. Chem., 25, 4, 343–349.

[35] Bintang M., 2010, Biokimia Teknik Penelitian, Erlangga, Jakarta, Ed. xvi, p.256.

[36] Ebada, S., Edrada, R.A., Lin, W., and Proksch, P., 2008, Nat. Protoc., 3, 12, 1820–1831.

[37] Rivera, A.P., and Uy, M.M., 2012, J. Chem., 9, 1, 354–358.

[38] Chaudary, A., Singla, S.K., and Tandon, C., 2010, Indian J. Pharmacol. Sci., 72, 3, 340–345.

[39] Wet, D.H., 2005, An Ethnobotanical and Chemataxonomix Study of South African Menispermaceae, Thesis, University of Johannesburg.

[40] Baniecki, M.L., Wirth, D.F., and Clardy, J., 2007, Antimicrob. Agents Chemother., 51, 2, 716–723.

[41] Ringwald, P., Bickii, J., and Basco, L.K., 1999, Am. J. Trop. Med. Hyg., 61, 2, 187–192.

[42] Pavia, D.L., Lampman, G.M., Kriz G.S., 2001, Introduction to Spectroscopy, 3rd ed., Brooks/Cole Thomson Learning, p. 390.

[43] Blunt, J.W., and Munro, M.H.G., 2007, Dictionary of Marine Natural Products with CD-ROM, Boca Raton: Chapman and Hall/CRC.



DOI: https://doi.org/10.22146/ijc.21276

Article Metrics

Abstract views : 2341 | views : 2305


Copyright (c) 2013 Indonesian Journal of Chemistry

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 

Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

Web Analytics View The Statistics of Indones. J. Chem.