FIRST-ROW TRANSITION METAL COMPLEXES OF OMEPRAZOLE AS ANTI-ULCERATIVE DRUGS

https://doi.org/10.22146/ijc.21447

Suman Malik(1), Supriya Das(2*), Bharti Jain(3)

(1) Department of Chemistry, Sadhu Vaswani College Bairagarh, Bhopal
(2) Department of Chemistry, Sadhu Vaswani College Bairagarh, Bhopal
(3) Department of Chemistry, Sarojni Naidu Govt. Girls College, Bhopal
(*) Corresponding Author

Abstract


Omeprazole (OME) is a proton pump inhibitor (PPI). PPIs have enabled to improve the treatment of various acid-peptic disorders. OME is a weak base and it can form several complexes with transition and non-transition metal ions. In the present paper, we are describing series of transition metal complexes of omeprazole i.e., 5-methoxy-2[(4methoxy-3, 5dimethyl-2-pyridinyl) methylsulfinyl]-1H-benzimidazole with CuII, MnII, CoII, NiII, FeII, ZnII andHgII. These complexes were characterized by elemental analysis, molar conductivity, IR, NMR, magnetic susceptibility, UV-visible spectral studies, ESR, SEM and X-ray diffraction. Based on the above studies, the ligand behaves as bidentate O, N donor and forms coordinate bonds through C=N and S=O groups. The complexes were found to non-electrolytic in nature on the basis of low values of molar conductivity. Analytical data and stoichiometry analysis suggest ligand to metal ratio of 2:1 for all the complexes. Electronic spectra and magnetic susceptibility measurements reveal octahedral geometry for Mn(II),Co(II), Ni(II),Fe(II) and Cu(II) complexes and tetrahedral for Hg(II) and Zn(II) complexes. Ligands and their metal complexes have been screened for their antibacterial and antifungal activities against bacteria Pseudomonas, Staphylococcus aureus and fungi Aspergillus niger and A. flavous.

Keywords


Complex; Omeprazole; Antibacterial; Ligand; Stoichiometry

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References

[1] Biasco, G., Miglioli, M., Barbara, L., and Corinaldesi, R., 1998, Am. J. Med., 129, 547–550.

[2] Soll, A.H., 1996, Abstr. J. Am. Med. Assoc., 275, 8, 622–629.

[3] DeVault, K.R., and Castell, D.O., 2005, Am. J. Gastroenterol., 100, 190–200.

[4] Spechler, J.S., 2000, Mt. Sinai J. Med., 67, 106–111.

[5] Brown, M., and Yang, R.D., 2001, Suppl. Manage Care Mag., 10, 10, 7–10.

[6] Vanderhoff, B.T., and Tahboub, R.M., 2002, Am. Fam. Physician, 66, 2, 273–281.

[7] Mui, A.C.W., and Fan, T.C.Y., 2007, Hong Kong. Med. J., 13, 430–435.

[8] Devlin, J.W., 2005, Am. J. Health-Syst. Pharm., 62, 10, S24–S29.

[9] Vidaillac, C., Guillon, J., Arpin, C., Forfar-Bares, I., Ba, B.B., Grellet, J., Moreau, S., Caignard, D-H., Jarry, C., and Quentin, C., 2007, Antimicrob. Agents Chemother., 51, 3, 831–838.

[10] Reedijk, J, 1987, J. Pure Appl. Chem., 59, 181–192

[11] Lochrer, P.J., and Einhorn, L.H., 1984, Ann. Intern. Med., 100, 704–713.

[12] Toney, J.H., Brock, C.P., and Marks, T.J., 1986, J. Am. Chem. Soc., 108, 7265.

[13] Forestier, J., 1935, J. Lab. Clin. Med., 20, 827–40.

[14] Bansal, A., and Singh, R.V., 2001, Synth. React. Inorg. Met.-Org. Chem., 31, 381.

[15] Singh, A., and Singh, P., 2000, Indian J. Chem., 39A, 874–879.

[16] Job, P., 1928, Ann. Chim., 11, 113–203.

[17] Turner, S.E., and Anderson, R.C., 1949, J. Am. Chem. Soc., 71, 912–914.

[18] Nakamoto, K., 1976, Infrared Spectra of Inorganic and Co-ordination Compounds, John Wiley, New York.

[19] Vogel, I., 1954, Quantitative Inorganic Analysis Longman, Green and Co., London, 455.

[20] Bellamy, L.J., 1956, Chemical Application of Spectroscopy, Interscience Publishers, New York.

[21] Weiss Berge, A., 1956, Chemical Application of Spectroscopy, Interscience Publishers, New York.

[22] Krishna, C.H., Mahapatra, C.M., and Dash, K.A., 1977, J. Inorg. Nucl. Chem., 39, 1253.

[23] Carlin, R.L., and Vandryneveledt, A.J., 1997, Magnetic Properties of Transition Metal Compounds, Springer- Verlag, New York.

[24] Figgis, B.N., 1976, Introduction to Ligand Fields, Wiley Eastern Ltd., New Delhi , 279.

[25] Silverstein, R.M., and Bassler, G.C., 1967, Spectrometric Identification of Organic Compounds, 2nd ed., Wiley, New York.

[26] Pople, J.A., Schneider, W.G., and Berstein, H.J., 1959, High Reduction Nuclear Magnetic Resonance, McGraw Hill Company, New York.

[27] Dutta, R.L., and Syanal, A., 1992, Electron spin resonance responses, In Elements of Magneto chemistry, 2nd ed., East-West Press, New Delhi, 206–250.

[28] Cheng Dong, Computer Software ‘Powder X’, Institute of Physics, Chinese Academy of Science, Beijing 1000080.

[29] Collins, C.H., and Lye, 1976, Microbiological Methods, 4th ed., Butterworth, London, 235.



DOI: https://doi.org/10.22146/ijc.21447

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