A New Thiourea Compound as Potential Ionophore for Metal Ion Sensor

Fatimatul Akma Awang Ngah; Emma Izzati Zakariah; Imran Fakhar; Nurul Izzaty Hassan; Lee Yook Heng; Bohari Yamin; Siti Aishah Hasbullah

doi:10.22146/ijc.27078

A New Thiourea Compound as Potential Ionophore for Metal Ion Sensor

https://doi.org/10.22146/ijc.27078

Fatimatul Akma Awang Ngah⁽¹⁾, Emma Izzati Zakariah⁽²⁾, Imran Fakhar⁽³⁾, Nurul Izzaty Hassan⁽⁴⁾, Lee Yook Heng⁽⁵⁾, Bohari Yamin⁽⁶⁾, Siti Aishah Hasbullah^(7*)

(1) School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 46000 Bangi, Selangor, Malaysia
(2) School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 46000 Bangi, Selangor, Malaysia
(3) School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 46000 Bangi, Selangor, Malaysia
(4) School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 46000 Bangi, Selangor, Malaysia
(5) School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 46000 Bangi, Selangor, Malaysia
(6) School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 46000 Bangi, Selangor, Malaysia
(7) School of Chemical Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 46000 Bangi, Selangor, Malaysia
(*) Corresponding Author

Abstract

A new thiourea compound, 2,2-oxybis(ethyl)-4-(1-naphthyl)-3-thiourea 3 has been synthesized and characterized by using FTIR, ¹H-NMR, ¹³C-NMR, and MS spectroscopy. The binding properties of with various cations were also carried out using ‘naked eye’, UV-vis and ¹H-NMR titration experiments. This compound exhibited effective binding for Hg²⁺ in the presence of other cations, such as Ag⁺, Ni²⁺, Sn²⁺, Zn²⁺, Fe²⁺, Cu^2+, and Pb²⁺. Continuous variation titration experiments were conducted in order to determine the binding behavior for Hg²⁺. Stoichiometry of the host and guest binding interactions were also determined using continuous variation titration experiments and plotting molar-ratio curves. Pearson Product moment method was employed to calculate the correlation coefficient, and non-linear regression equation was used to calculate dissociation constant K_d. Molar-ratio and binding constant data substantiated the presence of binding sites for the compound 3.

Keywords

thiourea; ionophore; sensor; mercury

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DOI: https://doi.org/10.22146/ijc.27078