Evaluation of Total Flavonoid, Total Phenolic Contents, and Antioxidant Activity of Strychnobiflavone

https://doi.org/10.22146/ijc.44331

Sana Ullah(1), Chang-Gu Hyun(2*)

(1) Department of Chemistry and Cosmetics, Jeju National University, Jeju 63243, South Korea
(2) Department of Chemistry and Cosmetics, Jeju National University, Jeju 63243, South Korea
(*) Corresponding Author

Abstract


This work evaluates the antioxidant activity of strychnobiflavone due to the increasing demand of the antioxidant agents day by day. Various in vitro antioxidants assays such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) were used to investigate the antioxidant activity of strychnobiflavone. The results of both DPPH and ABTS show that strychnobiflavone increase the scavenging activity in a concentration-dependent manner due to the phenolic and flavonoid contents. This study revealed that strychnobiflavone is one of the promising and an effective compound for the antioxidant agent.

Keywords


antioxidant activity; total flavonoid; strychnobiflavone

Full Text:

Full Text PDF


References

[1] Mandal, M., Misra, D., Ghosh, N.N., and Mandal, V., 2017, Physicochemical and elemental studies of Hydrocotyle javanica Thunb. for standardization as herbal drug, Asian Pac. J. Trop. Biomed., 7 (11), 979–986.

[2] Qi, Z., 2015, WHO Traditional medicine strategy 2014-2023, Global Health History Seminar on Traditional Medicine and Ayurveda, 19 March 2015,WHO-HQ, Geneva.

[3] Tilburt, J.C., and Kaptchuk, T.J., 2008, Herbal medicine research and global health: An ethical analysis, Bull. World Health Organ., 86 (8), 594–599.

[4] Kamboj, A., 2012, “Analytical evaluation of herbal drugs” in Drug Discovery Research in Pharmacognosy, Eds. Vallisuta, O., and Olimat, S.M., IntechOpen, Rijeka, Croatia, 23–60.

[5] Gupta, V.K., Kumria, R., Garg, M., and Gupta, M., 2010, Recent updates on free radicals scavenging flavonoids: An overview, Asian J. Plant Sci., 9 (3), 108–117.

[6] Roy, P., Abdulsalam, F.I., Pandey, D.K., Bhattacharjee, A., Eruvaram, N.R., and Malik, T., 2015, Evaluation of antioxidant, antibacterial, and antidiabetic potential of two traditional medicinal plants of India: Swertia cordata and Swertia chirayita, Pharmacogn. Res., 7 (Suppl. 1), S57–S62.

[7] Tachakittirungrod, S., Okonogi, S., and Chowwanapoonpohn, S., 2007, Study on antioxidant activity of certain plants in Thailand: Mechanism of antioxidant action of guava leaf extract, Food Chem., 103 (2), 381–388.

[8] Joseph, J., Cole, G., Head, E., and Ingram, D., 2009, Nutrition, brain aging, and neurodegeneration, J. Neurosci., 29 (41), 12795–12801.

[9] Riley, P.A., 1994, Free radicals in biology: oxidative stress and the effects of ionizing radiation, Int. J. Radiat. Biol., 65 (1), 27–33.

[10] Willcox, J.K., Ash, S.L., and Catignani, G.L., 2004, Antioxidants and prevention of chronic disease, Crit. Rev. Food Sci. Nutr., 44 (4), 275–295.

[11] Wan, C., Yu, Y., Zhou, S., Liu, W., Tian, S., and Cao, S., 2011, Antioxidant activity and free radical-scavenging capacity of Gynura divaricata leaf extracts at different temperatures, Pharmacogn. Mag., 7 (25), 40–45.

[12] Pisoschi, A.M., and Negulescu, G.P., 2011, Methods for total antioxidant activity determination: A review, Biochem. Anal. Biochem., 1 (1), 106.

[13] Liyana-Pathirana, C.M., Shahidi, F., and Alasalvar, C., 2006, Antioxidant activity of cherry laurel fruit (Laurocerasus officinalis Roem.) and its concentrated juice, Food Chem., 99 (1), 121–128.

[14] de Quirós, A.R.B., and Costa, H.S., 2006, Analysis of carotenoids in vegetable and plasma samples: A review, J. Food Compos. Anal., 19 (2-3), 97–111.

[15] Gey, K.F., 1990, The antioxidant hypothesis of cardiovascular disease: Epidemiology and mechanisms, Biochem. Soc. Trans., 18 (6), 1041–1045.

[16] Thompson, M., Williams, C.R., and Elliot, G.E.P., 1976, Stability of flavonoid complexes of copper(II) and flavonoid antioxidant activity, Anal. Chim. Acta, 85 (2), 375–381.

[17] Gey, K.F., Puska, P., Jordan, P., and Moser, U.K., 1991, Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology, Am. J. Clin. Nutr., 53 (1), 326S–334S.

[18] Olmedilla, B., Granado, F., Gil-Martinez, E., Blanco, I., and Rojas-Hidalgo, E., 1997, Reference values for retinol, tocopherol, and main carotenoids in serum of control and insulin-dependent diabetic Spanish subjects, Clin. Chem., 43 (6), 1066–1071.

[19] Weisburger, J.H., 1999, Mechanisms of action of antioxidants as exemplified in vegetables, tomatoes and tea, Food Chem. Toxicol., 37 (9-10), 943–948.

[20] Gillman, M.W., Cupples, L.A., Gagnon, D., Posner, B.M., Ellison, R.C., Castelli, W.P., and Wolf, P.A., 1995, Protective effect of fruits and vegetables on development of stroke in men, JAMA, 273 (14), 1113–1117.

[21] Rimm, E.B., Ascherio, A., Giovannucci, E., Spiegelman, D., Stampfer, M.J., and Willett, W.C., 1996, Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men, JAMA, 275 (6), 447–451.

[22] Cohen, J.H., Kristal, A.R., and Stanford, J.L., 2000, Fruit and vegetable intakes and prostate cancer risk, J. Natl. Cancer Inst., 92 (1), 61–68.

[23] Lage, P.S., Chávez-Fumagalli, M.A., Mesquita, J.T., Mata, L.M., Fernandes, S.O.A., Cardoso, V.N., Soto, M., Tavares, C.A.P., Leite, J.P.V., Tempone, A.G., and Coelho, E.A.F., 2015, Antileishmanial activity and evaluation of the mechanism of action of strychnobiflavone flavonoid isolated from Strychnos pseudoquina against Leishmania infantum, Parasitol. Res., 114 (12), 4625–4635.

[24] Travasarou, A., Angelopoulou, M.T., Vougogiannopoulou, K., Papadopoulou, A., Aligiannis, N., Cantrell, C.L., Kletsas, D., Fokialakis, N., and Pratsinis, H., 2019, Bioactive metabolites of the stem bark of Strychnos aff. darienensis and evaluation of their antioxidant and UV protection activity in human skin cell cultures, Cosmetics, 6 (1), 7.

[25] Xiao, L., Takada, H., Maeda, K., Haramoto, M., and Miwa, N., 2005, Antioxidant effects of water-soluble fullerene derivatives against ultraviolet ray or peroxylipid through their action of scavenging the reactive oxygen species in human skin keratinocytes, Biomed. Pharmacother., 59 (7), 351–358.

[26] Mu'nisa, A., Hala, Y., and Muflihunna, A., 2007, Analysis of phenols and antioxidants infused sappan wood (Caesalpiniasappan L.), IJSDR, 2 (9), 89–93.

[27] Martins, N., Barros, L., and Ferreira, I.C.F.R., 2016, In vivo antioxidant activity of phenolic compounds: Facts and gaps, Trends Food Sci. Technol., 48, 1–12.

[28] Panche, A.N., Diwan, A.D., and Chandra, S.R., 2016, Flavonoids: An overview, J. Nutr. Sci., 5, e47.

[29] Harman, D., 1962, Role of free radicals in mutation, cancer, aging, and the maintenance of life, Radiat. Res., 16 (5), 753–763.



DOI: https://doi.org/10.22146/ijc.44331

Article Metrics

Abstract views : 3491 | views : 3153


Copyright (c) 2020 Indonesian Journal of Chemistry

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 

Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

Web Analytics View The Statistics of Indones. J. Chem.