Sesquiterpenoids from the Stem Bark of  Aglaia simplicifolia  and Their Cytotoxic Activity against B16-F10 Melanoma Skin Cancer Cell

Ghina Izdihar; Al Arofatus Naini; Desi Harneti; Rani Maharani; Nurlelasari Nurlelasari; Tri Mayanti; Agus Safari; Kindi Farabi; Unang Supratman; Mohamad Nurul Azmi; Yoshihito Shiono

doi:10.22146/ijc.68383

Sesquiterpenoids from the Stem Bark of Aglaia simplicifolia and Their Cytotoxic Activity against B16-F10 Melanoma Skin Cancer Cell

https://doi.org/10.22146/ijc.68383

Ghina Izdihar⁽¹⁾, Al Arofatus Naini⁽²⁾, Desi Harneti⁽³⁾, Rani Maharani⁽⁴⁾, Nurlelasari Nurlelasari⁽⁵⁾, Tri Mayanti⁽⁶⁾, Agus Safari⁽⁷⁾, Kindi Farabi⁽⁸⁾, Unang Supratman^(9*), Mohamad Nurul Azmi⁽¹⁰⁾, Yoshihito Shiono⁽¹¹⁾

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(3) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(4) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia Central Laboratory of Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(5) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(6) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(7) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(8) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(9) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia Central Laboratory of Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(10) School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia
(11) Department of Bioresources Engineering, Faculty of Agriculture, Yamagata University, Tsuruoka-shi, Yamagata 997-8555, Japan
(*) Corresponding Author

Abstract

Four sesquiterpenoid derivatives, i.e., 4β,10α-dihydroxyaromadendrane (1), caryophyllenol-II (2), senecrassidiol (3), and clovane-2β,9α-diol (4) have been isolated from the stem bark of Aglaia simplicifolia. The chemical structures of compounds 1-4 were determined based on spectroscopic data, including one and two-dimensional NMR and mass spectroscopy. In addition, these sesquiterpenoids 1-4, were also tested for their cytotoxic activity against B16-F10 melanoma skin cancer cell lines through in vitro assay. Among the isolated compounds 1-4, compound 1 showed the highest activity with an IC₅₀ value of 44.8 μg/mL, suggesting the presence of a cyclopropane ring that plays an essential role in cytotoxic activity against B16-F10 melanoma skin cancer cell lines.

Keywords

Aglaia simplicifolia; cytotoxic activity; B16-F10 cell lines; sesquiterpenoid; Meliaceae

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DOI: https://doi.org/10.22146/ijc.68383